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Database: UniProt
Entry: H2KVH8_CLOSI
LinkDB: H2KVH8_CLOSI
Original site: H2KVH8_CLOSI 
ID   H2KVH8_CLOSI            Unreviewed;       734 AA.
AC   H2KVH8;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   27-SEP-2017, entry version 24.
DE   SubName: Full=Two pore segment channel 2 {ECO:0000313|EMBL:GAA30826.2};
GN   ORFNames=CLF_112386 {ECO:0000313|EMBL:GAA30826.2};
OS   Clonorchis sinensis (Chinese liver fluke).
OC   Eukaryota; Metazoa; Platyhelminthes; Trematoda; Digenea;
OC   Opisthorchiida; Opisthorchiata; Opisthorchiidae; Clonorchis.
OX   NCBI_TaxID=79923 {ECO:0000313|EMBL:GAA30826.2, ECO:0000313|Proteomes:UP000008909};
RN   [1] {ECO:0000313|Proteomes:UP000008909}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Wang X., Chen W., Huang Y., Sun J., Men J., Liu H., Luo F., Guo L.,
RA   Lv X., Deng C., Zhou C., Fan Y., Li X., Huang L., Hu Y., Liang C.,
RA   Hu X., Xu J., Yu X.;
RT   "The draft genome of the carcinogenic human liver fluke Clonorchis
RT   sinensis.";
RL   Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; DF144616; GAA30826.2; -; Genomic_DNA.
DR   InParanoid; H2KVH8; -.
DR   Proteomes; UP000008909; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005216; F:ion channel activity; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR028798; TPC2.
DR   PANTHER; PTHR10037:SF270; PTHR10037:SF270; 1.
DR   Pfam; PF00520; Ion_trans; 2.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000008909};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008909};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     19       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        20    734       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003564244.
FT   TRANSMEM     71     91       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    133    153       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    203    228       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    339    360       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    380    400       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    412    434       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    454    475       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    487    515       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    579    602       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       35    231       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      344    601       Ion_trans. {ECO:0000259|Pfam:PF00520}.
SQ   SEQUENCE   734 AA;  83383 MW;  80587E2D6B60C0D1 CRC64;
     MAISILFLLP LFEWPSSLTL SSDIRKNAVR PRLPCGVTES VELMCLLVIL LESICLCCAF
     ERSWVKRNPW LLGRFVVFSI YLADLSVSLA FSCNEFHRIR RFLRPYFLIS NSQLMKKLLK
     CLRRTLPKLL STLFLLLLWL VCASMVALCV FSGRHHTGSG AANSTDSSSS FPDFYRTMIN
     LLVLTTTANH PDVLVGMYNQ NRATAIFSIV FLGLGLYVLM NILTAIIYSE FRGYMLSSVQ
     ARLTRRRLAI RAAFEVLAIL DHRSDLVRSD RLIELLDSIN ISSWKKEALR EVYVSNFGES
     DLNVTQFMQL FRTLDLSSPR FTSDRLPPVS SRFAQFLQAW LVSYSFYKLS IAVSFLNIVN
     LAIDISSHLK SPGVSVQLRI TSWCFVAFYL LEQCGLMWAY GVKPFFSKLS NVFNLIVVLF
     LLIAKLIELA FLIYANGKFP THLVDFPLWD IVNITNILLL MRAVRLVNIF VWTSLVTSVL
     KDLPRNLAPV LGILLSVYYV YALLGMSLFH GVIVYNANSS STENLQCGTY QQLQYWSINF
     DDFAASIVLL WDLMVVNNWH VIVTAYQQTL NNWIHLYMIS WWLIAPVGLL SLVTAFVIES
     FLHRRDLYTK AIALANHPKE VVHVSGNPTL DLTVGPSKGL SVNPSRTASS CSHRTETFSE
     PIVYGTTPVT VFQPERYEET VFTISTSSLD DLFRAALQEP SEDELLLQLK QHKQLQRQLR
     AAQFANTVVQ ESTD
//
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