ID H2KYM2_CAEEL Unreviewed; 638 AA.
AC H2KYM2;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 89.
DE SubName: Full=DH domain-containing protein {ECO:0000313|EMBL:CCD63881.1};
GN Name=unc-73 {ECO:0000313|EMBL:CCD63881.1,
GN ECO:0000313|WormBase:F55C7.7g};
GN ORFNames=CELE_F55C7.7 {ECO:0000313|EMBL:CCD63881.1}, F55C7.7
GN {ECO:0000313|WormBase:F55C7.7g};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CCD63881.1, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CCD63881.1, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CCD63881.1,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
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DR EMBL; BX284601; CCD63881.1; -; Genomic_DNA.
DR RefSeq; NP_001249513.1; NM_001262584.1.
DR AlphaFoldDB; H2KYM2; -.
DR SMR; H2KYM2; -.
DR PeptideAtlas; H2KYM2; -.
DR EnsemblMetazoa; F55C7.7g.1; F55C7.7g.1; WBGene00006805.
DR GeneID; 171988; -.
DR AGR; WB:WBGene00006805; -.
DR WormBase; F55C7.7g; CE43442; WBGene00006805; unc-73.
DR OrthoDB; 2906033at2759; -.
DR Proteomes; UP000001940; Chromosome I.
DR Bgee; WBGene00006805; Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues.
DR ExpressionAtlas; H2KYM2; baseline and differential.
DR GO; GO:0030424; C:axon; IDA:WormBase.
DR GO; GO:0005737; C:cytoplasm; IDA:WormBase.
DR GO; GO:0019898; C:extrinsic component of membrane; IBA:GO_Central.
DR GO; GO:0036194; C:muscle cell projection; IDA:WormBase.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IDA:WormBase.
DR GO; GO:0031267; F:small GTPase binding; IPI:WormBase.
DR GO; GO:0007411; P:axon guidance; IBA:GO_Central.
DR GO; GO:0016477; P:cell migration; TAS:WormBase.
DR GO; GO:0018991; P:egg-laying behavior; TAS:WormBase.
DR GO; GO:0009792; P:embryo development ending in birth or egg hatching; NAS:WormBase.
DR GO; GO:0043652; P:engulfment of apoptotic cell; IGI:WormBase.
DR GO; GO:0048808; P:male genitalia morphogenesis; IMP:WormBase.
DR GO; GO:0008078; P:mesodermal cell migration; TAS:WormBase.
DR GO; GO:0002119; P:nematode larval development; NAS:WormBase.
DR GO; GO:0001764; P:neuron migration; IMP:WormBase.
DR GO; GO:0030838; P:positive regulation of actin filament polymerization; IDA:WormBase.
DR GO; GO:0045773; P:positive regulation of axon extension; IMP:WormBase.
DR GO; GO:0035022; P:positive regulation of Rac protein signal transduction; IC:WormBase.
DR GO; GO:0035025; P:positive regulation of Rho protein signal transduction; IC:WormBase.
DR GO; GO:0016601; P:Rac protein signal transduction; IC:WormBase.
DR GO; GO:0040012; P:regulation of locomotion; IMP:WormBase.
DR GO; GO:0040028; P:regulation of vulval development; TAS:WormBase.
DR CDD; cd13241; PH2_Kalirin_Trio_p63RhoGEF; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR22826; RHO GUANINE EXCHANGE FACTOR-RELATED; 1.
DR PANTHER; PTHR22826:SF106; TRIO, ISOFORM A; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|EPD:H2KYM2,
KW ECO:0007829|PeptideAtlas:H2KYM2};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 12..77
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 249..427
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 445..553
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 68..178
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 521..543
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 570..638
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 83..101
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 110..178
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 522..538
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 638 AA; 69931 MW; 6672F94566B0E72E CRC64;
MVIKCFTCLR KQSSEVWIVT ADFDGQVEGH LTVHKGDRVE IVEDQATDCA EYVQVVLCDQ
PTKHGLVPAS IIAPPESGSV PDRPDDSNAS GSTVSKRKSL RRIFANSSKE RAAAANSSSS
NNNSPATRQS TSTSSPVTAN GHTTESSTSA PIGVLSSGEP TSSNSIPSSS TPTHTVPSSV
PATVIPIVVA EDEKAEDCLP PPMENITINN SIDEKDMNED SVAASDAVEP EVALPAKVEK
TPEETARFKR SYVLMELVET EQDYVKDLTS VVEGYIGNLN KMDLPADLVG KDKIIFANIV
NILEFHKTNF LKEIEKCSEN YEAAGAAFVK YERRLHTLYV TYCQNKPKSD YLLAQDDFEA
FFADTKAKLG HKVALCDLLI KPVQRIMKYQ LLLKDILKFT ERAKDKTDTL KKALQVMHVV
PKACDDMMQV GRLQNFDKSL SAQGKLIHQG TLQISESIAG NVQKPKDRRI FLFEQSAIIA
DHIPPKKEFG NPTYIFKSQF MVNKMVFEPN VPDDPLRFVI KSSDPTQPTS FIANAQSQEE
KDEWNRKMSE LLDQQKRLLA ALVDPRRYND MSSGMGDLSL GAPGGDRRGA PSSANRSAAS
SSKKPAESPK KEGKSKSSLF SFGKKPAKSP TSPPPVGK
//
