ID H2KZX7_CAEEL Unreviewed; 877 AA.
AC H2KZX7;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 89.
DE SubName: Full=Rap guanine nucleotide exchange factor 1 {ECO:0000313|EMBL:CCD70386.1};
GN ORFNames=CELE_Y34B4A.4 {ECO:0000313|EMBL:CCD70386.1}, Y34B4A.4
GN {ECO:0000313|EMBL:CCD70386.1, ECO:0000313|WormBase:Y34B4A.4a};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CCD70386.1, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CCD70386.1, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CCD70386.1,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
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DR EMBL; BX284606; CCD70386.1; -; Genomic_DNA.
DR RefSeq; NP_001024958.1; NM_001029787.1.
DR AlphaFoldDB; H2KZX7; -.
DR SMR; H2KZX7; -.
DR STRING; 6239.Y34B4A.4a.1; -.
DR EPD; H2KZX7; -.
DR PaxDb; 6239-Y34B4A-4a; -.
DR PeptideAtlas; H2KZX7; -.
DR EnsemblMetazoa; Y34B4A.4a.1; Y34B4A.4a.1; WBGene00021320.
DR GeneID; 180798; -.
DR KEGG; cel:CELE_Y34B4A.4; -.
DR AGR; WB:WBGene00021320; -.
DR WormBase; Y34B4A.4a; CE21520; WBGene00021320; -.
DR eggNOG; KOG3417; Eukaryota.
DR HOGENOM; CLU_011586_0_0_1; -.
DR InParanoid; H2KZX7; -.
DR OMA; TTHEEQF; -.
DR OrthoDB; 68574at2759; -.
DR PhylomeDB; H2KZX7; -.
DR Reactome; R-CEL-170968; Frs2-mediated activation.
DR Reactome; R-CEL-8875555; MET activates RAP1 and RAC1.
DR Reactome; R-CEL-9013423; RAC3 GTPase cycle.
DR Reactome; R-CEL-912631; Regulation of signaling by CBL.
DR Proteomes; UP000001940; Chromosome X.
DR Bgee; WBGene00021320; Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues.
DR ExpressionAtlas; H2KZX7; baseline and differential.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IBA:GO_Central.
DR GO; GO:0007265; P:Ras protein signal transduction; IBA:GO_Central.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF99; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 1; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 1: Evidence at protein level;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Proteomics identification {ECO:0007829|EPD:H2KZX7,
KW ECO:0007829|PeptideAtlas:H2KZX7};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940}.
FT DOMAIN 490..614
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 637..869
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 219..245
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 260..301
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 267..282
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 283..301
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 877 AA; 100665 MW; 0EC0BA2C68E14CD1 CRC64;
MSKEIDISIR YLENVLSTNN STLILSSTAA VLEAVSKNCD TTNGELKRSI ISLLRIIDKK
CFLNQDVDVN QIKFSLQEVG KLSTKYPKSH QKPGNEVKVK TNAEFREIET VPNPDEENID
NLLNQLNLKK VPSFSPAFPD IGDDSDDENG ITTKQKEEER AEQHGQKVCE EEVVKLPDGR
EIRMKKTKTV NVKQTTKHVT ISTKSANMPE VSRTFMNARR GFDEDEEEEN TNFGSSNMRG
GDPFERFRSM LKDKDEKIEA IEGESSSDPG TPGSSSKSKT IERTSEVSQK VSEKKEKDGR
LLAEHEASKL DKSNLFAKQV DTYQGAALID RKGEGSYEES TLVRSALPQD SQVATPPRMH
VVEYMMMFGD DKKNNENEYL KGTTISSYVR LNNNLTTHEE QFKKKIQFEF STAGTSSTTI
DLDNLSDLLN QTDFNCLRPP NKFLEDTPLI VEQPKAIDWQ REPTSAPPEK DLLLEHDGVD
YVIFREKEGK VLEVRGGPKD ALIVYATQST HSSLLYQEAF LITFRTFISS LELVNKLIKR
YLYMSLADDS QSESIARHTF SVIVRIIDET TQYELDFDLI TSVTSFVYRL IHDGNFTYSR
ILRTRLLDRI KDSFDIQTVL GTNLCKPRKP HDLFDFKSAE IACQLTFIDS QLYHRIESAE
LLWWAQEQNE KKSKNLVNFT EQFNNLSFWV RTLIITQGTQ KERERHMMKF VKIMKHLREM
CNFNSYLAIL SAIMSTPLAR LEWSKNIKDA LKEHTAVMDT AQSYKNYRAL LQTAKPPCVP
YIGIILQDLT FVHAGNPDTI PSDRCHGAKN MINFLKRWNQ FAILDSIRKL KKWNYDIKKN
DIVVQYFNGF KDCIDEERTW QLSHQIKPSN RKSKTQA
//
