ID H2L2G5_CAEEL Unreviewed; 250 AA.
AC H2L2G5;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 76.
DE SubName: Full=Guanylate cyclase domain-containing protein {ECO:0000313|EMBL:CCE71398.1};
GN Name=gcy-35 {ECO:0000313|EMBL:CCE71398.1,
GN ECO:0000313|WormBase:T04D3.4b};
GN ORFNames=CELE_T04D3.4 {ECO:0000313|EMBL:CCE71398.1}, T04D3.4
GN {ECO:0000313|WormBase:T04D3.4b};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CCE71398.1, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CCE71398.1, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CCE71398.1,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP = 3',5'-cyclic GMP + diphosphate; Xref=Rhea:RHEA:13665,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57746; EC=4.6.1.2;
CC Evidence={ECO:0000256|ARBA:ARBA00001436};
CC -!- SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl cyclase
CC family. {ECO:0000256|RuleBase:RU000405}.
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DR EMBL; BX284601; CCE71398.1; -; Genomic_DNA.
DR RefSeq; NP_001252133.1; NM_001265204.1.
DR AlphaFoldDB; H2L2G5; -.
DR SMR; H2L2G5; -.
DR EnsemblMetazoa; T04D3.4b.1; T04D3.4b.1; WBGene00001555.
DR GeneID; 173202; -.
DR AGR; WB:WBGene00001555; -.
DR WormBase; T04D3.4b; CE46771; WBGene00001555; gcy-35.
DR HOGENOM; CLU_011614_4_0_1; -.
DR OrthoDB; 2898719at2759; -.
DR Proteomes; UP000001940; Chromosome I.
DR Bgee; WBGene00001555; Expressed in larva and 3 other cell types or tissues.
DR ExpressionAtlas; H2L2G5; baseline and differential.
DR GO; GO:0070025; F:carbon monoxide binding; IDA:WormBase.
DR GO; GO:0070026; F:nitric oxide binding; IDA:WormBase.
DR GO; GO:0019825; F:oxygen binding; IDA:WormBase.
DR GO; GO:0019826; F:oxygen sensor activity; IMP:WormBase.
DR GO; GO:0016849; F:phosphorus-oxygen lyase activity; IEA:InterPro.
DR GO; GO:0009454; P:aerotaxis; IMP:WormBase.
DR GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0055093; P:response to hyperoxia; IMP:WormBase.
DR GO; GO:0070482; P:response to oxygen levels; IMP:WormBase.
DR CDD; cd07302; CHD; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR018297; A/G_cyclase_CS.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR PANTHER; PTHR11920:SF335; GUANYLATE CYCLASE 32E; 1.
DR PANTHER; PTHR11920; GUANYLYL CYCLASE; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR SMART; SM00044; CYCc; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR PROSITE; PS00452; GUANYLATE_CYCLASE_1; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000405};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 1..114
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT REGION 206..250
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 206..229
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 250 AA; 27893 MW; 1488F23976779F4F CRC64;
MCTPYDVVTL LNDLYLRFDR LVGLHDAYKV ETIGDAYMIV GGVPERCENH AERVLNISIG
MLMESKLVLS PITHKPIKIR LGVHCGPVVA GVVGIKMPRY CLFGDTVNVA NKMESNGIQC
KIHVSETGKL NGLKANPSYV FIDRGNTEIR GKGMMYTYFL ERNDRKSVWE LCSRPRSGEQ
TIDGYMELHD QSIYQEEGGQ QENLTVENGN SAQNNHNNNN NTHHSGRKLM NGSSVDPGSH
HIRSPTCTIS
//
