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Database: UniProt
Entry: H2L3X3_ORYLA
LinkDB: H2L3X3_ORYLA
Original site: H2L3X3_ORYLA 
ID   H2L3X3_ORYLA            Unreviewed;       824 AA.
AC   H2L3X3;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   25-OCT-2017, entry version 29.
DE   SubName: Full=Transient receptor potential cation channel, subfamily M, member 1a {ECO:0000313|Ensembl:ENSORLP00000000453};
OS   Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae;
OC   Oryziinae; Oryzias.
OX   NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000000453, ECO:0000313|Proteomes:UP000001038};
RN   [1] {ECO:0000313|Proteomes:UP000001038}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hd-rR {ECO:0000313|Proteomes:UP000001038};
RX   PubMed=17554307; DOI=10.1038/nature05846;
RA   Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B.,
RA   Yamada T., Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D.,
RA   Shimada A., Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A.,
RA   Asakawa S., Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K.,
RA   Sugano S., Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F.,
RA   Nomoto H., Nogata K., Morishita T., Endo T., Shin-I T., Takeda H.,
RA   Morishita S., Kohara Y.;
RT   "The medaka draft genome and insights into vertebrate genome
RT   evolution.";
RL   Nature 447:714-719(2007).
RN   [2] {ECO:0000313|Ensembl:ENSORLP00000000453}
RP   IDENTIFICATION.
RC   STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000000453};
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSORLP00000000453}.
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DR   EMBL; BAAF04080126; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BAAF04080127; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BAAF04080128; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BAAF04080129; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BAAF04080130; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSORLT00000000453; ENSORLP00000000453; ENSORLG00000000365.
DR   GeneTree; ENSGT00760000119127; -.
DR   Proteomes; UP000001038; Chromosome 3.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005216; F:ion channel activity; IEA:InterPro.
DR   GO; GO:0051262; P:protein tetramerization; IEA:InterPro.
DR   Gene3D; 1.20.5.1010; -; 1.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR032415; TRPM_tetra.
DR   InterPro; IPR037162; TRPM_tetra_sf.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF16519; TRPM_tetra; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001038};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    395    414       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    462    480       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    531    551       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    607    632       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      400    641       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      736    791       TRPM_tetra. {ECO:0000259|Pfam:PF16519}.
SQ   SEQUENCE   824 AA;  95833 MW;  DEBDD620A91CDD2C CRC64;
     MMDALVLDRV DFVRLLIENG VNIHHFLTIP RLEELYNTKL GPTNTLHFLV RDVKKETPLC
     PPGWGKATFK GNLPPDYQIT LIDIGLVLEF LMGGAYRCNY TRKSFRTLYN NLYGLKRPKA
     LKLLGMEDDE TPVKGKWKKN KKKEEELDID VDDPEVCRFQ YPFHELMVWA VLMKRQKMAL
     FLWQRGEEAM AKALVACKLY KAMAHESSQS ELVDDIYQDL ENNSKEFGLL AYELLDQSYK
     HDEQVAMKLL TYELKNWSNS TCLKLAVAAK HRDFIAHTCS QMLLTDMWMG CLRMGKSNSL
     KVIIGIIFPP AIPLLEFRLG DEASHHSSKD SSDGNNKDDN KASKVQNKDT EVFKVDAMSN
     ADTVSKKGDE ENHKHQRVPI GRKIYEFYNA PFTKFWFNTI SYLVYLMLYN YIILVKMERL
     PCLQEWIVIS YIITLGLEKV RQILMSEPGK LRQKFIVWLE DYWNITDLVA ISAFLLGLLL
     RVQREPYMGY GRVIYCVDII FWYIRVLDIF GVNKYLGPYV MMIGKMMIDM LYFVVIMLVV
     LMSFGVARQA ILHPDEEPTW RLARNIFYMP YWMIYGEVFA DSIDPPCGEN MYDEDGKKLP
     PCIPGAWLTP AIMACYLLVA NILLVNLLIA VFNNTFFEVK SISNQVWKFQ RYQLIMTFHD
     RPILPPPLII LPHIYIVLKR LCCRCRQRPE GEHDERERRL QLVLNAEELK SLHEFEEQCV
     EEYFRGKEDE NQSSTKERIR VTSDRVENMA MRLEEVNERE HSMKASLQTV DIRLAQLEEF
     SNRMMNALEK LAGVDRAELV CSRGSSVYQP SSLLRHSSIS SADG
//
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