ID H2L5C5_ORYLA Unreviewed; 1455 AA.
AC H2L5C5;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1 {ECO:0000313|Ensembl:ENSORLP00000000992.2};
GN Name=PREX1 {ECO:0000313|Ensembl:ENSORLP00000000992.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000000992.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000000992.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000000992.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000000992.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000000992.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR Ensembl; ENSORLT00000000993.2; ENSORLP00000000992.2; ENSORLG00000000806.2.
DR eggNOG; KOG3519; Eukaryota.
DR GeneTree; ENSGT00940000159925; -.
DR HOGENOM; CLU_003935_0_0_1; -.
DR TreeFam; TF328639; -.
DR Proteomes; UP000001038; Chromosome 7.
DR Bgee; ENSORLG00000000806; Expressed in pharyngeal gill and 14 other cell types or tissues.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd04439; DEP_1_P-Rex; 1.
DR CDD; cd04440; DEP_2_P-Rex; 1.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd01224; PH_Collybistin_ASEF; 1.
DR Gene3D; 2.30.42.10; -; 2.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR037367; Rex2_DEP_1.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR22829; DEP DOMAIN PROTEIN; 1.
DR PANTHER; PTHR22829:SF6; PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE-DEPENDENT RAC EXCHANGER 1 PROTEIN; 1.
DR Pfam; PF00610; DEP; 2.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00049; DEP; 2.
DR SMART; SM00228; PDZ; 2.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50156; PDZ domain-like; 2.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 2.
DR PROSITE; PS50186; DEP; 2.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50106; PDZ; 2.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001038}.
FT DOMAIN 1..65
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 96..216
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 246..320
FT /note="DEP"
FT /evidence="ECO:0000259|PROSITE:PS50186"
FT DOMAIN 353..421
FT /note="DEP"
FT /evidence="ECO:0000259|PROSITE:PS50186"
FT DOMAIN 450..497
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 534..594
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
SQ SEQUENCE 1455 AA; 164967 MW; 0DB60848A9B7222E CRC64;
MLLGGKKSTD IPLEGYLLSP IQRICKYPLL LKELLKRTPK SHADYPAVQE ALQAMKAVCS
NINETKRQME KLEALEQLQS HIEGWEGTNL TDICTELLLH GNLLKISAGN IQERVFFLFD
NLLVYCKRKS RVSGKKSTKR TKSINGPLYV FRGRINTEVM EVENVEDGTA DYHSNNYTVT
NGWKIHNTAK NKWFVCMAKN AEDKQKWLDA ILREREQRES LKLGMERDAY VMIAEKGEKL
YHMMMTKNRH LIKDRRRKLS IVPKCFMGNE FVAWLIESGE ISKPEEGVNL GQALLENGII
HHISDKHQFK NEQVLYRFRY DDGTYKARSE MEDIMSKGVR LYCRLHCLHT PVIKDRDYHL
KTFKSVVPAC KLVDWLISQG DCSTREDAVT LGVGLCNNGF MHHVLEKSEF KDESQFFRFY
ADEETEGTST KSKQLQRNDF KLIENILAKS LVIHPEEEGY GFEIEEKNKA IVVKSVSRGS
HAEMAGLQVG RKIYTINEDL LFLRPFSEVE TMISQAFCIR RSLRLLVATK AKEVVKIPDN
PDSLSFRLCG SAPPHVHAVR KGWEAAGAGL QPGQVVLKVN GNNVNHSDYQ EVLEHFAAQH
THQECNWVYR AFEDVEHLQR GRSPTEKEQN AFKPFPLCRL SLSDDLPLVS LTVDNVHLEH
GVVYEYVNTA GIKSHVLEKI TEPKGCFSLT AKILEAFCSD DSLFVRNCSQ LISQSDRVVT
MPQYEFRQIC DTKLESISRR ITCYQQFAQE LRNKVWPSVR QAGGRPHPLG CMDFIPTNCH
INLMQVSCPK STTSAGRTFS IRFGRKNSIF GLDQDQAQLN LMSHTLHCMT SMGAPSWSCS
GLEGDEADGS GDVTLEDGEG VMDGRQGVHG EGGLSFLLKP EDTEAQDSYI HLYSRLDVAV
REMKQYVAQI DVLLSSITEP TELQREEGGS LVYDPNQPPP LAPCDDGCEQ DKAEQGGIKR
VCFKVNEEDQ EDSGHDTMSY RDSYSECNSN RDSVLSYTSV RSNSSYLGSD EMGSGDELPC
DMRIPSDKQD KLHGCLEHLF NQVDSINSLL KGTQFRQTED WTSRCRHIIH KNIQEDPWNL
PNSIKTLVES LQRFVDDGKN QLLLALLKCT DTSLQLRRDV IFCQAATAAL CTLAEQLLMA
LRLRFNNAGE YQEDSKETSC KWLEQISVIG ALLHFQSTLN PHLKEERTML EDTKAALLDL
DKVTVFFRQL EDECLVTNTP VCYQVEGSRQ ALKVTMYLDS CHFSELPSRL QNGGGLRLNT
VLFTRALERA EGVSQREYTE MEELQQRTNA VSLEKVKAYY RRLRAFYLEK SNLPTDSNST
AMKIDQLLRP LNTLDDLCRL MQSYVNVRST SQGHPSGVSV LCVSSELCNR LGACHITMCG
TGMQRCTLSV TLEQAMILAR NHGLIPRCIM QTMDIMRKQG ARVELSAKNL KVMDQMPPSA
PRLFRLCLPP SDGDL
//
