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Database: UniProt
Entry: H2L615_ORYLA
LinkDB: H2L615_ORYLA
Original site: H2L615_ORYLA 
ID   H2L615_ORYLA            Unreviewed;      1386 AA.
AC   H2L615;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 2.
DT   24-JAN-2024, entry version 65.
DE   SubName: Full=Alpha-2-macroglobulin-like protein 1 {ECO:0000313|Ensembl:ENSORLP00000001258.2};
GN   Name=LOC101161298 {ECO:0000313|Ensembl:ENSORLP00000001258.2};
OS   Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC   Oryzias.
OX   NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000001258.2, ECO:0000313|Proteomes:UP000001038};
RN   [1] {ECO:0000313|Ensembl:ENSORLP00000001258.2, ECO:0000313|Proteomes:UP000001038}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000001258.2,
RC   ECO:0000313|Proteomes:UP000001038};
RX   PubMed=17554307; DOI=10.1038/nature05846;
RA   Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA   Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA   Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA   Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA   Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA   Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT   "The medaka draft genome and insights into vertebrate genome evolution.";
RL   Nature 447:714-719(2007).
RN   [2] {ECO:0000313|Ensembl:ENSORLP00000001258.2}
RP   IDENTIFICATION.
RC   STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000001258.2};
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- SIMILARITY: Belongs to the protease inhibitor I39 (alpha-2-
CC       macroglobulin) family. {ECO:0000256|ARBA:ARBA00010952}.
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DR   STRING; 8090.ENSORLP00000001258; -.
DR   Ensembl; ENSORLT00000001259.2; ENSORLP00000001258.2; ENSORLG00000023081.1.
DR   eggNOG; KOG1366; Eukaryota.
DR   GeneTree; ENSGT00940000166660; -.
DR   InParanoid; H2L615; -.
DR   TreeFam; TF313285; -.
DR   Proteomes; UP000001038; Chromosome 2.
DR   Bgee; ENSORLG00000023081; Expressed in gastrula and 6 other cell types or tissues.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   CDD; cd02897; A2M_2; 1.
DR   Gene3D; 1.50.10.20; -; 1.
DR   Gene3D; 2.20.130.20; -; 1.
DR   Gene3D; 2.60.120.1540; -; 1.
DR   Gene3D; 2.60.40.1930; -; 2.
DR   Gene3D; 2.60.40.1940; -; 1.
DR   Gene3D; 2.60.40.690; Alpha-macroglobulin, receptor-binding domain; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR   InterPro; IPR009048; A-macroglobulin_rcpt-bd.
DR   InterPro; IPR036595; A-macroglobulin_rcpt-bd_sf.
DR   InterPro; IPR011625; A2M_N_BRD.
DR   InterPro; IPR041813; A2M_TED.
DR   InterPro; IPR047565; Alpha-macroglob_thiol-ester_cl.
DR   InterPro; IPR011626; Alpha-macroglobulin_TED.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR001599; Macroglobln_a2.
DR   InterPro; IPR019742; MacrogloblnA2_CS.
DR   InterPro; IPR002890; MG2.
DR   InterPro; IPR041555; MG3.
DR   InterPro; IPR040839; MG4.
DR   InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR   PANTHER; PTHR11412:SF160; ALPHA-2-MACROGLOBULIN-LIKE PROTEIN 1; 1.
DR   PANTHER; PTHR11412; MACROGLOBULIN / COMPLEMENT; 1.
DR   Pfam; PF00207; A2M; 1.
DR   Pfam; PF07703; A2M_BRD; 1.
DR   Pfam; PF07677; A2M_recep; 1.
DR   Pfam; PF01835; MG2; 1.
DR   Pfam; PF17791; MG3; 1.
DR   Pfam; PF17789; MG4; 1.
DR   Pfam; PF07678; TED_complement; 1.
DR   SMART; SM01360; A2M; 1.
DR   SMART; SM01359; A2M_N_2; 1.
DR   SMART; SM01361; A2M_recep; 1.
DR   SMART; SM01419; Thiol-ester_cl; 1.
DR   SUPFAM; SSF49410; Alpha-macroglobulin receptor domain; 1.
DR   SUPFAM; SSF81296; E set domains; 1.
DR   SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
DR   PROSITE; PS00477; ALPHA_2_MACROGLOBULIN; 1.
PE   3: Inferred from homology;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Protease inhibitor {ECO:0000256|ARBA:ARBA00022690};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525};
KW   Serine protease inhibitor {ECO:0000256|ARBA:ARBA00022900}.
FT   DOMAIN          424..568
FT                   /note="Alpha-2-macroglobulin bait region"
FT                   /evidence="ECO:0000259|SMART:SM01359"
FT   DOMAIN          694..783
FT                   /note="Alpha-2-macroglobulin"
FT                   /evidence="ECO:0000259|SMART:SM01360"
FT   DOMAIN          1306..1380
FT                   /note="Alpha-macroglobulin receptor-binding"
FT                   /evidence="ECO:0000259|SMART:SM01361"
SQ   SEQUENCE   1386 AA;  153421 MW;  F0F9ADD3D7A1B32E CRC64;
     SHLTAGNKET LCALIQTPTE PVTLTITLDL DSSSTKIGQL FLRTEIYRCF QFLVPIVSST
     TVASISVKIQ GKMDSLNQET KVLIEPPAFV HIVQTDKPIY KPGQTVQFRI VSMDNNFIPV
     NRMVRFYIHF LKQDPNSNRI AQWLDKSIDR GILDLSHPTI PEAAQGIYVI TAETDKGETI
     SHNFEIKEYV LPKFEVTVNL PSVITILDDE VTLKICGKYT YGKPVLGSVK AEFCRRANQY
     SWLPSPKQDD ICKTFELSTD KSGCATQNVA LAGFAINAYN YFDSFEVTAE LEEFGTGVIL
     KASGSASFTT QIRTVSFEDL PSSYKPGLPL EGKIKVTGAD GSPIANQAVY LYAVDSLEFT
     LYTDQKGIAV FSLDTSSWSE SVSLSATTII KRKNEQTVPE VRFPDYGTAY QYVTRFYSQS
     KSFVGFSENS VDIPCDKNGF LLAQYIIQGE DLQKGQRFLS FYYLVSSSHF MALFLNVSPV
     IKGKIKIPLT NVIDLAPIAQ VVVYTMISSG EVVADSRDFP IQLCLNNKVS LKFSAVQELP
     GAKTTMTLRA HPSSLCSVRA IDQSVLLLKS EEELTVDYVY NQLPIKKMWG YDYQVEDDSF
     NPCFPEPWPR PIPLEPTLLP RGRREKRSRI VPFYEGGDVY TIFKVNGFIV FVFLLFFSAR
     PLAILGANRQ PVIPQVPAPE GQKTETIRTY FPETWIWDLV SVGSSGSTSL VKTVPDTLTK
     WAAGAFCVSP AGFGVAPNVG LTAFQPFFVS LTLPYSVVRG EVFTLKATVF NYLPKCIMVK
     ATLAKSDQFT FKNCDGCVYS SVCLCAEESK TFSWIVTPTA LGDVTLKVSA EAEKSNKKCG
     TEAVTVPTVG QVDTVITTLL VEVKGPVSKN ISLELPEKFV AGSERASVSV VGDLMGRAMK
     NLDKLLAMPY GCGEQNMLLF APNIFILDYL KSTGQLKEST RKMAVGYLES GYQRELNYKH
     DNGSYSAFGM SDPSGNTWLT TFVMKSFNAA KQYIFVDQKY IQDARTWLSG LQKLDGCIQS
     VGKLFHNGMK GGVSDDVSLT AYVAAAMLEL DGNATNPVVQ NCLKCLRTAA SSKITNLYTV
     ALLSYTFTLA GDQDVRSKLI TLLDQKSINE GGTRHWKRDD APETGLDSVE VEMTSYVLLA
     LLSGPSLPGF GLDYAAGIVR WLAQQQNPFG GFSSTQDTVV ALQALAKYAT ATFSLEGSTT
     VTVTSVGGLN KRFTVNKDNR LLYQEEKLNE IPGEYTIEAE GQSCVLAQIS LFYNIPPPSD
     FSAFQISTNT SGRCDIPRPE FMLFVHVEFQ GRREETNMVR FLFGLTTCVL FVSQLKENRL
     VKRVDVEEGF INIYLDGLKK GQKETFDVIL EEDQQVGNLK PAVVKVYDYY QTSDEAVTDY
     TSPCNK
//
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