ID H2L615_ORYLA Unreviewed; 1386 AA.
AC H2L615;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 24-JAN-2024, entry version 65.
DE SubName: Full=Alpha-2-macroglobulin-like protein 1 {ECO:0000313|Ensembl:ENSORLP00000001258.2};
GN Name=LOC101161298 {ECO:0000313|Ensembl:ENSORLP00000001258.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000001258.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000001258.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000001258.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000001258.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000001258.2};
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the protease inhibitor I39 (alpha-2-
CC macroglobulin) family. {ECO:0000256|ARBA:ARBA00010952}.
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DR STRING; 8090.ENSORLP00000001258; -.
DR Ensembl; ENSORLT00000001259.2; ENSORLP00000001258.2; ENSORLG00000023081.1.
DR eggNOG; KOG1366; Eukaryota.
DR GeneTree; ENSGT00940000166660; -.
DR InParanoid; H2L615; -.
DR TreeFam; TF313285; -.
DR Proteomes; UP000001038; Chromosome 2.
DR Bgee; ENSORLG00000023081; Expressed in gastrula and 6 other cell types or tissues.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR CDD; cd02897; A2M_2; 1.
DR Gene3D; 1.50.10.20; -; 1.
DR Gene3D; 2.20.130.20; -; 1.
DR Gene3D; 2.60.120.1540; -; 1.
DR Gene3D; 2.60.40.1930; -; 2.
DR Gene3D; 2.60.40.1940; -; 1.
DR Gene3D; 2.60.40.690; Alpha-macroglobulin, receptor-binding domain; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR009048; A-macroglobulin_rcpt-bd.
DR InterPro; IPR036595; A-macroglobulin_rcpt-bd_sf.
DR InterPro; IPR011625; A2M_N_BRD.
DR InterPro; IPR041813; A2M_TED.
DR InterPro; IPR047565; Alpha-macroglob_thiol-ester_cl.
DR InterPro; IPR011626; Alpha-macroglobulin_TED.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR001599; Macroglobln_a2.
DR InterPro; IPR019742; MacrogloblnA2_CS.
DR InterPro; IPR002890; MG2.
DR InterPro; IPR041555; MG3.
DR InterPro; IPR040839; MG4.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR PANTHER; PTHR11412:SF160; ALPHA-2-MACROGLOBULIN-LIKE PROTEIN 1; 1.
DR PANTHER; PTHR11412; MACROGLOBULIN / COMPLEMENT; 1.
DR Pfam; PF00207; A2M; 1.
DR Pfam; PF07703; A2M_BRD; 1.
DR Pfam; PF07677; A2M_recep; 1.
DR Pfam; PF01835; MG2; 1.
DR Pfam; PF17791; MG3; 1.
DR Pfam; PF17789; MG4; 1.
DR Pfam; PF07678; TED_complement; 1.
DR SMART; SM01360; A2M; 1.
DR SMART; SM01359; A2M_N_2; 1.
DR SMART; SM01361; A2M_recep; 1.
DR SMART; SM01419; Thiol-ester_cl; 1.
DR SUPFAM; SSF49410; Alpha-macroglobulin receptor domain; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
DR PROSITE; PS00477; ALPHA_2_MACROGLOBULIN; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Protease inhibitor {ECO:0000256|ARBA:ARBA00022690};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Serine protease inhibitor {ECO:0000256|ARBA:ARBA00022900}.
FT DOMAIN 424..568
FT /note="Alpha-2-macroglobulin bait region"
FT /evidence="ECO:0000259|SMART:SM01359"
FT DOMAIN 694..783
FT /note="Alpha-2-macroglobulin"
FT /evidence="ECO:0000259|SMART:SM01360"
FT DOMAIN 1306..1380
FT /note="Alpha-macroglobulin receptor-binding"
FT /evidence="ECO:0000259|SMART:SM01361"
SQ SEQUENCE 1386 AA; 153421 MW; F0F9ADD3D7A1B32E CRC64;
SHLTAGNKET LCALIQTPTE PVTLTITLDL DSSSTKIGQL FLRTEIYRCF QFLVPIVSST
TVASISVKIQ GKMDSLNQET KVLIEPPAFV HIVQTDKPIY KPGQTVQFRI VSMDNNFIPV
NRMVRFYIHF LKQDPNSNRI AQWLDKSIDR GILDLSHPTI PEAAQGIYVI TAETDKGETI
SHNFEIKEYV LPKFEVTVNL PSVITILDDE VTLKICGKYT YGKPVLGSVK AEFCRRANQY
SWLPSPKQDD ICKTFELSTD KSGCATQNVA LAGFAINAYN YFDSFEVTAE LEEFGTGVIL
KASGSASFTT QIRTVSFEDL PSSYKPGLPL EGKIKVTGAD GSPIANQAVY LYAVDSLEFT
LYTDQKGIAV FSLDTSSWSE SVSLSATTII KRKNEQTVPE VRFPDYGTAY QYVTRFYSQS
KSFVGFSENS VDIPCDKNGF LLAQYIIQGE DLQKGQRFLS FYYLVSSSHF MALFLNVSPV
IKGKIKIPLT NVIDLAPIAQ VVVYTMISSG EVVADSRDFP IQLCLNNKVS LKFSAVQELP
GAKTTMTLRA HPSSLCSVRA IDQSVLLLKS EEELTVDYVY NQLPIKKMWG YDYQVEDDSF
NPCFPEPWPR PIPLEPTLLP RGRREKRSRI VPFYEGGDVY TIFKVNGFIV FVFLLFFSAR
PLAILGANRQ PVIPQVPAPE GQKTETIRTY FPETWIWDLV SVGSSGSTSL VKTVPDTLTK
WAAGAFCVSP AGFGVAPNVG LTAFQPFFVS LTLPYSVVRG EVFTLKATVF NYLPKCIMVK
ATLAKSDQFT FKNCDGCVYS SVCLCAEESK TFSWIVTPTA LGDVTLKVSA EAEKSNKKCG
TEAVTVPTVG QVDTVITTLL VEVKGPVSKN ISLELPEKFV AGSERASVSV VGDLMGRAMK
NLDKLLAMPY GCGEQNMLLF APNIFILDYL KSTGQLKEST RKMAVGYLES GYQRELNYKH
DNGSYSAFGM SDPSGNTWLT TFVMKSFNAA KQYIFVDQKY IQDARTWLSG LQKLDGCIQS
VGKLFHNGMK GGVSDDVSLT AYVAAAMLEL DGNATNPVVQ NCLKCLRTAA SSKITNLYTV
ALLSYTFTLA GDQDVRSKLI TLLDQKSINE GGTRHWKRDD APETGLDSVE VEMTSYVLLA
LLSGPSLPGF GLDYAAGIVR WLAQQQNPFG GFSSTQDTVV ALQALAKYAT ATFSLEGSTT
VTVTSVGGLN KRFTVNKDNR LLYQEEKLNE IPGEYTIEAE GQSCVLAQIS LFYNIPPPSD
FSAFQISTNT SGRCDIPRPE FMLFVHVEFQ GRREETNMVR FLFGLTTCVL FVSQLKENRL
VKRVDVEEGF INIYLDGLKK GQKETFDVIL EEDQQVGNLK PAVVKVYDYY QTSDEAVTDY
TSPCNK
//