ID H2L7F9_ORYLA Unreviewed; 558 AA.
AC H2L7F9;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 70.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN Name=ddx56 {ECO:0000313|Ensembl:ENSORLP00000001771.1};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000001771.1, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000001771.1, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000001771.1,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000001771.1}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000001771.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_004074527.1; XM_004074479.2.
DR AlphaFoldDB; H2L7F9; -.
DR STRING; 8090.ENSORLP00000001771; -.
DR Ensembl; ENSORLT00000001772.2; ENSORLP00000001771.1; ENSORLG00000001434.2.
DR GeneID; 101168798; -.
DR KEGG; ola:101168798; -.
DR CTD; 54606; -.
DR eggNOG; KOG0346; Eukaryota.
DR GeneTree; ENSGT00550000074946; -.
DR HOGENOM; CLU_003041_17_1_1; -.
DR InParanoid; H2L7F9; -.
DR OMA; GDIDRCY; -.
DR OrthoDB; 227126at2759; -.
DR TreeFam; TF300620; -.
DR Proteomes; UP000001038; Chromosome 12.
DR Bgee; ENSORLG00000001434; Expressed in gastrula and 14 other cell types or tissues.
DR GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR CDD; cd17961; DEADc_DDX56; 1.
DR CDD; cd18787; SF2_C_DEAD; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014014; RNA_helicase_DEAD_Q_motif.
DR PANTHER; PTHR47959:SF13; ATP-DEPENDENT RNA HELICASE RHLE; 1.
DR PANTHER; PTHR47959; ATP-DEPENDENT RNA HELICASE RHLE-RELATED; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS51195; Q_MOTIF; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038}.
FT DOMAIN 6..34
FT /note="DEAD-box RNA helicase Q"
FT /evidence="ECO:0000259|PROSITE:PS51195"
FT DOMAIN 37..215
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 227..425
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 316..342
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 517..558
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 6..34
FT /note="Q motif"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00552"
FT COMPBIAS 327..342
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 558 AA; 62801 MW; E53EAF0EDF09AD88 CRC64;
MACERLQFHE MGLDDRLLKA VADLGWSQPT LIQEKAIPLA LEGKDLLARA RTGSGKTAAY
AVPIIQHILT SKQSVREQAV RVLVLVPTKE LGQQVQTMMR QLTSFCSRDV RVADISSKAD
VSSQRPILME KPDVVVGTPA RVLAHINAHN LDLQASLEVL VVDEADLIFS FGFEADLKSL
LCHLPKIYQS FLMSATFTED VQALKELLLH NPVVLKLQGS QLPDSSQLQQ YTIKCEEEDK
FLLVYTLLKL QLVRGKTLLF VGAVDRSYRL KLFLEQFSIP ACVLNSELPV QSRCHIITQF
NQGFYDIIIA TDEQSLSPPA GSSQTKGKEK KNADKGGKAK DKEFGVSRGV DFQNVANVIN
FDFPTTVESY IHRVGRTARA DNQGTALSFI SHTELPLLVE VEEALSTDNA ESVLKPYQFR
MEEIEGFRYR CRDAMRAVTK QAVREARLKE IKQELLNSEK LKTYFDDNPR DLQLLRHDKD
LHPAVVKPHM KNIPDYLIPQ TLRGVVNPLS GRRKRWRVKP PAEGVARSSF KKNDPSRNPL
KSFRYTRGRN KAAKAGKS
//
