ID H2L7Z7_ORYLA Unreviewed; 262 AA.
AC H2L7Z7;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Hydroxysteroid (17-beta) dehydrogenase 14 {ECO:0000313|Ensembl:ENSORLP00000001965.2};
GN Name=hsd17b14 {ECO:0000313|Ensembl:ENSORLP00000001965.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000001965.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000001965.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000001965.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000001965.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000001965.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=17beta-estradiol + NAD(+) = estrone + H(+) + NADH;
CC Xref=Rhea:RHEA:24612, ChEBI:CHEBI:15378, ChEBI:CHEBI:16469,
CC ChEBI:CHEBI:17263, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.62;
CC Evidence={ECO:0000256|ARBA:ARBA00036587};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:24613;
CC Evidence={ECO:0000256|ARBA:ARBA00036587};
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DR RefSeq; XP_004071213.1; XM_004071165.2.
DR AlphaFoldDB; H2L7Z7; -.
DR STRING; 8090.ENSORLP00000001965; -.
DR Ensembl; ENSORLT00000001966.2; ENSORLP00000001965.2; ENSORLG00000001583.2.
DR GeneID; 101168290; -.
DR KEGG; ola:101168290; -.
DR CTD; 51171; -.
DR GeneTree; ENSGT00940000161346; -.
DR HOGENOM; CLU_010194_1_0_1; -.
DR InParanoid; H2L7Z7; -.
DR OrthoDB; 102925at2759; -.
DR Proteomes; UP000001038; Chromosome 8.
DR Bgee; ENSORLG00000001583; Expressed in liver and 15 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0004303; F:estradiol 17-beta-dehydrogenase [NAD(P)] activity; IBA:GO_Central.
DR GO; GO:0006706; P:steroid catabolic process; IBA:GO_Central.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR InterPro; IPR002347; SDR_fam.
DR PANTHER; PTHR43658:SF13; 17-BETA-HYDROXYSTEROID DEHYDROGENASE 14; 1.
DR PANTHER; PTHR43658; SHORT-CHAIN DEHYDROGENASE/REDUCTASE; 1.
DR Pfam; PF13561; adh_short_C2; 1.
DR PRINTS; PR00081; GDHRDH.
DR PRINTS; PR00080; SDRFAMILY.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00061; ADH_SHORT; 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038}.
SQ SEQUENCE 262 AA; 28098 MW; ED42F5A1976EF1BF CRC64;
MSFRYLGKVV IVTGGSRGIG RGITEAFVRN GAKVVFCALG EGDTVEAELN RTGPGSCKFV
RCDVTKEEDI KRLISSTVEL HGHIDCLVNN AGWHPPHKSI DDTTAEEFRD LLNLNLVSYF
LASKFALPYL RQRQGNIINI SSLVGSIGQK DAVPYVATKG AIISMTKAMA VDESQYHVRV
NCISPGNVMT PLWEELAAQT ADAAAAVKMG ENAQLMGRMG TEAECGLAAL YLAADATYCT
GIDLVLSGGA ELNYGFKSQI NT
//