ID H2L9V0_ORYLA Unreviewed; 1389 AA.
AC H2L9V0;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Par-3 family cell polarity regulator alpha, b {ECO:0000313|Ensembl:ENSORLP00000002648.2};
GN Name=pard3ab {ECO:0000313|Ensembl:ENSORLP00000002648.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000002648.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000002648.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000002648.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000002648.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000002648.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Endomembrane system
CC {ECO:0000256|ARBA:ARBA00004308}.
CC -!- SIMILARITY: Belongs to the PAR3 family.
CC {ECO:0000256|ARBA:ARBA00005358}.
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DR RefSeq; XP_011484259.1; XM_011485957.1.
DR STRING; 8090.ENSORLP00000002648; -.
DR Ensembl; ENSORLT00000002649.2; ENSORLP00000002648.2; ENSORLG00000002125.2.
DR GeneID; 101157642; -.
DR CTD; 403050; -.
DR eggNOG; KOG3528; Eukaryota.
DR GeneTree; ENSGT00950000183214; -.
DR HOGENOM; CLU_006629_0_0_1; -.
DR InParanoid; H2L9V0; -.
DR OrthoDB; 5405986at2759; -.
DR TreeFam; TF323729; -.
DR Proteomes; UP000001038; Chromosome 17.
DR Bgee; ENSORLG00000002125; Expressed in animal zygote and 13 other cell types or tissues.
DR GO; GO:0005912; C:adherens junction; IBA:GO_Central.
DR GO; GO:0043296; C:apical junction complex; IBA:GO_Central.
DR GO; GO:0016324; C:apical plasma membrane; IBA:GO_Central.
DR GO; GO:0005923; C:bicellular tight junction; IEA:UniProtKB-SubCell.
DR GO; GO:0005938; C:cell cortex; IBA:GO_Central.
DR GO; GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.
DR GO; GO:0035091; F:phosphatidylinositol binding; IBA:GO_Central.
DR GO; GO:0007155; P:cell adhesion; IBA:GO_Central.
DR GO; GO:0030010; P:establishment of cell polarity; IBA:GO_Central.
DR GO; GO:0051660; P:establishment of centrosome localization; IBA:GO_Central.
DR GO; GO:0045197; P:establishment or maintenance of epithelial cell apical/basal polarity; IBA:GO_Central.
DR GO; GO:0000226; P:microtubule cytoskeleton organization; IBA:GO_Central.
DR GO; GO:0008104; P:protein localization; IBA:GO_Central.
DR CDD; cd00992; PDZ_signaling; 3.
DR Gene3D; 2.30.42.10; -; 3.
DR InterPro; IPR021922; Par3/HAL_N.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR PANTHER; PTHR16484:SF10; PARTITIONING DEFECTIVE 3 HOMOLOG; 1.
DR PANTHER; PTHR16484; PARTITIONING DEFECTIVE 3 RELATED; 1.
DR Pfam; PF12053; Par3_HAL_N_term; 1.
DR Pfam; PF00595; PDZ; 3.
DR SMART; SM00228; PDZ; 3.
DR SUPFAM; SSF50156; PDZ domain-like; 3.
DR PROSITE; PS50106; PDZ; 3.
PE 3: Inferred from homology;
KW Cell junction {ECO:0000256|ARBA:ARBA00022427};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Tight junction {ECO:0000256|ARBA:ARBA00022427}.
FT DOMAIN 278..354
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 475..549
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 603..678
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 81..102
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 380..463
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 701..721
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 813..845
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 871..895
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 941..1389
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 88..102
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 380..412
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 444..463
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 875..895
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 992..1112
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1130..1145
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1146..1175
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1207..1236
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1248..1271
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1289..1303
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1318..1335
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1389 AA; 154307 MW; B9ADFC166579401A CRC64;
MKVTVCFGRT RVVVPCGDGN IKVRALIQQA VMRYKKAIAK DSNYWLQVHR LEHGDGGILD
LDDVLCDVAD DKDRLIAIYD EQEPHHGGDG TSASSTGTQS PDLFATDLSA GSGASAFQPY
KATSEIEVTP SALRTNMPLH VRRSSDPALL TVNGPFSAVE SRVQTEETPS RKTPTRWSTT
AGFLKARHCS GTNSLERKSK GLDTYRSLPR DAGTWANQRE FQRETARSSL SANHPMVDRW
LERQEQEETR EEGNGRIEPV GRADSCMEHT PFRSLEDIVQ VVEVSNDGGP LGIHVVPFSG
RDRRTLGLLV KRLEKGGKAE QQGLFQENDC IVRINNGDLR NIRFEQAQNM FRQAMRSPVI
MFHVVPSSMK VHYEQISHAE RNPSFSSGRY SPNFTAGGTG LNADQQKMSR HGSQSHPHAH
PHAHLHPEAA DTYPPLTHPA VTAAKPPTGQ THSPQKGLNS TLTSGYTKKV GRRLNIQLKK
GPEGLGFSIT SRDVPIGGSA PIYVKNILPR GAAIQDGRLK AGDRLLEVNG VDLNGRTQEE
VVALLRATPM GGAVGLLVLR QEDAFLPREV SAEPQIQHSN DLRTEEDELV LTPDGTREFL
TFEIPLSDSG SAGLGVSVKG NRSKENHADL GIFVKSIING GAACKDGRLR VNDQLIAVNG
ESLLGKTNQD AMETLRKSMS TEGNKRGMIQ LIVARRVVKR NEELPGSPPP SEQTVNTSLD
DHERRISHSL YGGLEGLDDN LMPRPGMIPR TIGNYQLSPT VNMPQDDTVI IEDDRPPLLP
PHLSDHSSSS SHEDVGFAAE GMPVWAKELP AHNDRTLSPD ENQPDGAFQR EGFGRQSMSE
KRTKQFGDAA QLEIIKTRKS KSMDLVADEI NLTPRPETGS GSSTKDVGPS LGLKKSSSLE
SLQTAVAEVT LNGDLPFHRP RPRIIRGRGC NESFRAAIDK SYDRPATVED DDEGMETLEE
DTEESSRSGR DSVSTVADQT PLSGMEKPLV NGTYRTKDEK KKDKDKGGKE KKKPEGGKEK
GKPKKGMLKG LGDMFRFGKY RKDERPGEKI DRKGSNKWKP EEAQASDEDM MKMRLEQERI
QAKTRELRER QARERDYAEI LDTSRTPERP SDDHYSAANP LNCSLDGGHS RPHSPRDDPF
HFNHQHQHSD ASLYSQLGKP RSERPPSTDS YRLTPSNHDR IQKLRQEFQQ AQNVPDDPDD
RRRTYSFEQS WSNVNSNGST GYSQPGRHSV SVEVQMQRQR QEERDSFAQQ QRQYSSLPRQ
PRKNPSTVSH DSWDKAYPPG EGFQMAKDNP RYSSYQGSRN GYPGGGSVNA RVLLEAQELL
RQEQRRREQE AKGKLMQESS GKSSYDGHTV HLKDPASPKG PYRHDVPPSP SQLARLNRLG
SEKGRLFYS
//
