ID H2LAZ1_ORYLA Unreviewed; 629 AA.
AC H2LAZ1;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=Nuclear RNA export factor 1a {ECO:0000313|Ensembl:ENSORLP00000003058.2};
GN Name=nxf1a {ECO:0000313|Ensembl:ENSORLP00000003058.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000003058.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000003058.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000003058.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000003058.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000003058.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus, nucleoplasm {ECO:0000256|ARBA:ARBA00004642}.
CC -!- SIMILARITY: Belongs to the NXF family. {ECO:0000256|ARBA:ARBA00009285}.
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DR AlphaFoldDB; H2LAZ1; -.
DR Ensembl; ENSORLT00000003059.2; ENSORLP00000003058.2; ENSORLG00000002462.2.
DR eggNOG; KOG3763; Eukaryota.
DR GeneTree; ENSGT00390000007539; -.
DR TreeFam; TF314566; -.
DR Proteomes; UP000001038; Chromosome 10.
DR Bgee; ENSORLG00000002462; Expressed in animal zygote and 14 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0006406; P:mRNA export from nucleus; IEA:InterPro.
DR CDD; cd14342; UBA_TAP-C; 1.
DR Gene3D; 3.10.450.50; -; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR Gene3D; 1.10.8.10; DNA helicase RuvA subunit, C-terminal domain; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR025875; Leu-rich_rpt_4.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR032710; NTF2-like_dom_sf.
DR InterPro; IPR002075; NTF2_dom.
DR InterPro; IPR018222; Nuclear_transport_factor_2_euk.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR030217; NXF_fam.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR005637; TAP_C_dom.
DR InterPro; IPR015245; Tap_RNA-bd.
DR InterPro; IPR009060; UBA-like_sf.
DR PANTHER; PTHR10662; NUCLEAR RNA EXPORT FACTOR; 1.
DR PANTHER; PTHR10662:SF22; NUCLEAR RNA EXPORT FACTOR 1; 1.
DR Pfam; PF12799; LRR_4; 1.
DR Pfam; PF02136; NTF2; 1.
DR Pfam; PF09162; Tap-RNA_bind; 1.
DR Pfam; PF03943; TAP_C; 1.
DR SMART; SM00804; TAP_C; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF54427; NTF2-like; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
DR SUPFAM; SSF46934; UBA-like; 1.
DR PROSITE; PS51450; LRR; 2.
DR PROSITE; PS50177; NTF2_DOMAIN; 1.
DR PROSITE; PS51281; TAP_C; 1.
PE 3: Inferred from homology;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW mRNA transport {ECO:0000256|ARBA:ARBA00022816};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 394..546
FT /note="NTF2"
FT /evidence="ECO:0000259|PROSITE:PS50177"
FT DOMAIN 575..629
FT /note="TAP-C"
FT /evidence="ECO:0000259|PROSITE:PS51281"
FT REGION 1..117
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..20
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 64..82
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 83..101
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 629 AA; 70754 MW; A5A9ACF90441020A CRC64;
MADGGHYYNE HDDRTAPFRN RKGRGGHKGR PFDRSRRDRQ RGSHTGVFGG PGPRSRLDDP
DGDVTMNDSS QDSSSQNRYT PYSRDGRKGD GRVDRSRRQG RGAGGGRGGG FREGDRGGLT
VKARSGWYKV TIPHGKKYDK KWLVPALQNI CSVPYTPVQF HVDHNRVHFY VDDHNTANAL
LKCSHKITDP EGYKVIVHVN PSAPPSFLLS DLKPEHLEYL KQCMAKRFDG SQQALDLNNI
RTDPDLVSQN IEVILNRKTS MEAVIKIIEE NIPELTCLNL SNNRIHKLDE LAELVSKVPN
LKTLNLSHNE LKTDRELDKL KGLKLVELWL NRNPLCALFK DQAAYISAVR QRFPRLLKLD
GQDLPPPIGF DVETPTAIPP CKGSCFGSDE IKVIILRFLQ QYYSIYDSGN RQPLLDAYHD
GASLSITTPY STQNPSRSSL GEYYKDSRNL KRIKDTTMRF RLLKHTRLNV VAFLNELPKT
QHDIASFVID VNTCTNTLLS FTIGGVFKEV VVDGKSREST MAFSRVFITV PAGNSGLCIV
NDQLFIRMAT TEEIRRAFVA PAPTPSSSPV PTLTAPQQEM LTAFSQESGM NLEWSQKCLQ
DNEWDFNRAA HIFTQLKAEG KIPDVAFIK
//
