ID H2LBE5_ORYLA Unreviewed; 532 AA.
AC H2LBE5;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=Amine oxidase {ECO:0000256|RuleBase:RU362067};
DE EC=1.4.3.- {ECO:0000256|RuleBase:RU362067};
GN Name=LOC101163441 {ECO:0000313|Ensembl:ENSORLP00000003217.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000003217.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000003217.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000003217.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000003217.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000003217.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974,
CC ECO:0000256|RuleBase:RU362067};
CC -!- SIMILARITY: Belongs to the flavin monoamine oxidase family.
CC {ECO:0000256|RuleBase:RU362067}.
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DR AlphaFoldDB; H2LBE5; -.
DR STRING; 8090.ENSORLP00000003217; -.
DR Ensembl; ENSORLT00000003218.2; ENSORLP00000003217.2; ENSORLG00000002585.2.
DR eggNOG; KOG0029; Eukaryota.
DR GeneTree; ENSGT00940000160928; -.
DR HOGENOM; CLU_004498_8_3_1; -.
DR InParanoid; H2LBE5; -.
DR OrthoDB; 3597164at2759; -.
DR TreeFam; TF313314; -.
DR Proteomes; UP000001038; Chromosome 18.
DR Bgee; ENSORLG00000002585; Expressed in pharyngeal gill and 7 other cell types or tissues.
DR GO; GO:0001716; F:L-amino-acid oxidase activity; IBA:GO_Central.
DR GO; GO:0046592; F:polyamine oxidase activity; IBA:GO_Central.
DR GO; GO:0009063; P:amino acid catabolic process; IBA:GO_Central.
DR Gene3D; 1.10.10.1620; -; 1.
DR Gene3D; 3.30.70.2100; -; 1.
DR Gene3D; 3.90.660.10; -; 1.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR Gene3D; 1.10.405.10; Guanine Nucleotide Dissociation Inhibitor, domain 1; 1.
DR InterPro; IPR002937; Amino_oxidase.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR001613; Flavin_amine_oxidase.
DR PANTHER; PTHR10742; FLAVIN MONOAMINE OXIDASE; 1.
DR PANTHER; PTHR10742:SF21; L-AMINO-ACID OXIDASE; 1.
DR Pfam; PF01593; Amino_oxidase; 1.
DR PRINTS; PR00757; AMINEOXDASEF.
DR SUPFAM; SSF54373; FAD-linked reductases, C-terminal domain; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|ARBA:ARBA00022827, ECO:0000256|RuleBase:RU362067};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630,
KW ECO:0000256|RuleBase:RU362067};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU362067};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..532
FT /note="Amine oxidase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017477198"
FT DOMAIN 67..505
FT /note="Amine oxidase"
FT /evidence="ECO:0000259|Pfam:PF01593"
SQ SEQUENCE 532 AA; 59454 MW; 16FD9B7D941D8328 CRC64;
MNLLEVKLYV SCVLLLALHS SSSAESLKEN LTDCLEDTDY DVLLQTVQEG LPNITAPHHV
VIVGAGMAGL TAAMLLQDAG HQVTILEANN RVGGRVETHR NTEEGWFAEL GAMRIPSFHQ
IVLWVATKLG VKMNTFVMDD PNTYYLVNGV KKRTYAVKGN ASLLGYKVQP SEKGKSADEL
LQQALEKIKS EVKAEGCQAA FKKYDHYSVK EYLKEVGGLS SEAVRMIGDL LNEQSLMHTA
LTEMIYDQTD ISDNSMYYEV TGGSDHLPRA FLNVLDSTLH LNSKVVRISQ SDGGVIVEYK
TVNESSFRQI QADLVLVTTT TKAALFIDFK PPLSIRKMEV MRSVHYDSAT KIFLTFREKF
WESEGIHGGK SITDRPSRFI YYPSHSFPQN QTIGVLLASY TWSDDSLLFL GASDEDLKEL
VLRDLAQIHG ERVRSLCTGV IVKRWSSDPY SMGAFALFTP YQHIEYSKEL FRSEGRIHFA
GEHTAFPHAW IETAMKSAIR AAVNINNEVL HGSDQNPGRF YSEPQCSLNV ES
//
