ID H2LCE2_ORYLA Unreviewed; 943 AA.
AC H2LCE2;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=General transcription factor IIIC, polypeptide 3 {ECO:0000313|Ensembl:ENSORLP00000003578.2};
GN Name=gtf3c3 {ECO:0000313|Ensembl:ENSORLP00000003578.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000003578.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000003578.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000003578.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000003578.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000003578.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; H2LCE2; -.
DR STRING; 8090.ENSORLP00000003578; -.
DR Ensembl; ENSORLT00000003579.2; ENSORLP00000003578.2; ENSORLG00000002865.2.
DR eggNOG; KOG2076; Eukaryota.
DR GeneTree; ENSGT00390000016929; -.
DR HOGENOM; CLU_066981_0_0_1; -.
DR InParanoid; H2LCE2; -.
DR Proteomes; UP000001038; Chromosome 15.
DR Bgee; ENSORLG00000002865; Expressed in gastrula and 14 other cell types or tissues.
DR GO; GO:0000127; C:transcription factor TFIIIC complex; IBA:GO_Central.
DR GO; GO:0006383; P:transcription by RNA polymerase III; IBA:GO_Central.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 3.
DR InterPro; IPR039340; Tfc4/TFIIIC-102/Sfc4.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR23082:SF0; GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 3; 1.
DR PANTHER; PTHR23082; TRANSCRIPTION INITIATION FACTOR IIIC TFIIIC , POLYPEPTIDE 3-RELATED; 1.
DR Pfam; PF13181; TPR_8; 3.
DR SMART; SM00028; TPR; 8.
DR SUPFAM; SSF48452; TPR-like; 2.
DR PROSITE; PS50005; TPR; 3.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339}.
FT REPEAT 254..287
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 518..551
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 868..901
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REGION 35..152
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 59..73
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 90..112
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 943 AA; 106858 MW; 61ED4152626A7143 CRC64;
MNDFARELTW NVKMSGFSSE LIDYLEGRIT FEEFDRRRDE RKAEESERGE DAEEDAQPCS
SAQILSQPED GVSPGVQQAF ASILGESAEP PSSEEEEDSL SYVDDEDDKD FVVEDKGSDA
KTGKGRKKHQ RGEGCGRRTQ KPKEEAEEEA EDVTVGDVFA LEMELSRENK KHMKGRRHGS
KLPTALRGLM GEANIRYARG EKDTAVQMCM EIIRQAPLAY EPFSTLAMIY EDEGDTDKSL
QFSLIAAHLN PSDCEEWIRL AEMSLEQNNI RQAIICYSKA IKYDPTNVRY LWERSSLHMR
LGEHKQCMDG YRRILSLLPL EDGEHFMQLS KDMAKSYYES NDLPSALSVI EEGLSRHPSL
VGDDFVNMAA ELYISSRQHS KALQVLVKFT DVVLVRENAT AEVPYRGEEA AEKKEANDKG
AALNLPEEMP AESCGDIKAV QIADSVPVDL RAKLMVCLIN LQVFTPLEPL VLSLMEQSPE
EIGDLYLDVG EAYLEQGCYT SALPLLSALV ISDKYNLAVV WLRHAECLKA LGHMEAAADS
YSKVVEMAPQ HLEARLSLAT LQQQLGHMDC ALKALESMYD SDTLAQDSSA AQKELKLLLH
RSTLLKTQGQ LHDYLDAVIS MISMLLKVAM QRAKVCVRAV PLSGVTHLRL QKLEERLPEI
SDHETAYSDN MCKTNVLSKE DWWQLLVSCI LTLCQLERYD EADLLVESAM EFYSFYDNKP
RRRELECFGL SATILDHNYC KAYNYIRLML IENVNLPQLW NIFNQLTINS QHQRHHRFCL
RLLLKYPNNH ALCVLCGHNA MVSGSFKHAL GQYVQAFQTH PDNPLYSLCV GLTFFHMASQ
KYVAKRHALV LQGFSFLWRY VELRGESQES MYNLGRALHQ MGLTHLAIHY YQKALELPAK
TLSGIADDQV DLRREIAFNL SLIYQASGNM AVARQLIYTH CTV
//
