ID H2LCR9_ORYLA Unreviewed; 522 AA.
AC H2LCR9;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Zgc:152830 {ECO:0000313|Ensembl:ENSORLP00000003709.2};
GN Name=zgc:152830 {ECO:0000313|Ensembl:ENSORLP00000003709.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000003709.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000003709.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000003709.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000003709.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000003709.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase M17 family.
CC {ECO:0000256|ARBA:ARBA00009528}.
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DR AlphaFoldDB; H2LCR9; -.
DR STRING; 8090.ENSORLP00000003709; -.
DR MEROPS; M17.011; -.
DR Ensembl; ENSORLT00000003710.2; ENSORLP00000003709.2; ENSORLG00000002965.2.
DR GeneTree; ENSGT00530000063255; -.
DR HOGENOM; CLU_013734_0_1_1; -.
DR InParanoid; H2LCR9; -.
DR OrthoDB; 1329669at2759; -.
DR Proteomes; UP000001038; Chromosome 9.
DR Bgee; ENSORLG00000002965; Expressed in intestine and 14 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0030145; F:manganese ion binding; IEA:InterPro.
DR GO; GO:0070006; F:metalloaminopeptidase activity; IEA:InterPro.
DR GO; GO:0008233; F:peptidase activity; IBA:GO_Central.
DR GO; GO:0006508; P:proteolysis; IBA:GO_Central.
DR CDD; cd00433; Peptidase_M17; 1.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR011356; Leucine_aapep/pepB.
DR InterPro; IPR000819; Peptidase_M17_C.
DR PANTHER; PTHR11963; LEUCINE AMINOPEPTIDASE-RELATED; 1.
DR PANTHER; PTHR11963:SF23; ZGC:152830; 1.
DR Pfam; PF00883; Peptidase_M17; 1.
DR PRINTS; PR00481; LAMNOPPTDASE.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
DR PROSITE; PS00631; CYTOSOL_AP; 1.
PE 3: Inferred from homology;
KW Aminopeptidase {ECO:0000256|ARBA:ARBA00022438};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038}.
FT DOMAIN 349..356
FT /note="Cytosol aminopeptidase"
FT /evidence="ECO:0000259|PROSITE:PS00631"
SQ SEQUENCE 522 AA; 56585 MW; C2175ADC4273776C CRC64;
MLFMSLCSVQ PTEWTSDLKN QNFDGIVLVA QSHESLPTKL ESLKAPLQDY NSVDSGLAED
VVILKVPGLP GNRLVYSSTG PVNRDYDDAR RFSDAAFNGI KRALKAGMQR PLLVCPPHRD
YSSSPLVAAL GALHALYMPL ELRETKINAS QYKVCVLGLW AEQEAEGKRL VELANALESG
RLAYRDIGGS DPERMAAPRA AEYVQELFKN SPVKVEVVSD LKTLEKEYPC LAAVNRCANI
VPRHQARVIK LQYCGEGPVQ KTLMLVGKGI TYDTGGADIK AGGFMAGMHR DKCGAAAVAG
FFQILAHLQP KHLKVVGSMA MVRNSVGADC YVADELVVSR AGRRVRVGNT DAEGRMVMVD
LLCEMKEKAP REISPHLFTI ATLTGHAIRA MGPNYSIIMD NGPAHRSGNA AQWQKAGEVL
GDVFEVSTIR REDYEFHKGK SEYEDILQAN NLPSSATPRG HQSPAAFLIM ASGLDKHGVD
SDTPLPYSHI DIAGSSGPFP GVPTGAPVLA MTTNYILKDG LN
//
