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Database: UniProt
Entry: H2LGT6_ORYLA
LinkDB: H2LGT6_ORYLA
Original site: H2LGT6_ORYLA 
ID   H2LGT6_ORYLA            Unreviewed;       834 AA.
AC   H2LGT6;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   05-JUL-2017, entry version 24.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   Name=atp6v0a1 {ECO:0000313|Ensembl:ENSORLP00000005185};
OS   Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae;
OC   Oryziinae; Oryzias.
OX   NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000005185, ECO:0000313|Proteomes:UP000001038};
RN   [1] {ECO:0000313|Proteomes:UP000001038}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hd-rR {ECO:0000313|Proteomes:UP000001038};
RX   PubMed=17554307; DOI=10.1038/nature05846;
RA   Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B.,
RA   Yamada T., Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D.,
RA   Shimada A., Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A.,
RA   Asakawa S., Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K.,
RA   Sugano S., Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F.,
RA   Nomoto H., Nogata K., Morishita T., Endo T., Shin-I T., Takeda H.,
RA   Morishita S., Kohara Y.;
RT   "The medaka draft genome and insights into vertebrate genome
RT   evolution.";
RL   Nature 447:714-719(2007).
RN   [2] {ECO:0000313|Ensembl:ENSORLP00000005185}
RP   IDENTIFICATION.
RC   STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000005185};
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSORLP00000005185}.
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DR   EMBL; BAAF04032319; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_011476258.1; XM_011477956.1.
DR   Ensembl; ENSORLT00000005186; ENSORLP00000005185; ENSORLG00000004136.
DR   GeneID; 101163575; -.
DR   eggNOG; KOG2189; Eukaryota.
DR   eggNOG; COG1269; LUCA.
DR   GeneTree; ENSGT00390000004941; -.
DR   Proteomes; UP000001038; Chromosome 8.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001038};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    401    425       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    445    464       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    544    565       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    571    595       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    636    660       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    766    790       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED       94    121       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   834 AA;  95396 MW;  DE0A94FB5623ADB2 CRC64;
     MGQLFRSEEM TLAQLFLQSE AAYCCVSELG EIGMVQFRDL NPDVNVFQRK FVNEVRRCEE
     MDRKLRFVEK EIKKANLAIL DTGENPEVPF PRDMIDLEAT FEKLENELKE INTNQEALKK
     NFLELTELKH ILRRTQQFFD EMEDPSLLEE SSTFLDPNEP IRAAPQRLGF VAGVIGRERI
     PTFERMLWRV CRGNVFLRQA DIEDPLEDPT TGDQVHKSVF IIFFQGDQLK NRVKKICEGF
     RATLYPCPET PQERKEMLAG VNARIDDLQM VLNQTEDHRQ RVLQAAAKTV RVWFIKVRKM
     KAIYHTLNLC NIDVTQKCLI AEVWCPVSDM DSIQFALRRG TEKSGSTVPS ILNSMQTKQT
     PPTYNKTNKF TSGFQNIVDA YGIGSYREIN PAPYTIITFP FLFAVMFGDL GHGALMTAAA
     LYLVLRESRL MAQKNDNEIF TMVFAGRYII LLMGIFSMYT GLIYNDCFSK ALNIFGSGWS
     VRPMFGERGA NWSFTTLSEN HVLQLDPAVD GVFKGPYPIG IDPIWSISIN KLTFLNSFKM
     KMSVILGVIH MLFGVSLSLF NHLYFKKPLN IYLGFIPEIV FMSCLFGYLV ILIFFKWVSF
     DARTSKDAPS LLIAFINMFL FQYSDPSNKP LYRGQMGLQI FLVIIALACV PCMLIVKTLV
     LRRQYLWQKH LGTQNFGGIR VSNGPTEDEA GIIQHDHLAP QTEDDPEFNF TDVAVHQAIH
     TIEYCLGCIS NTASYLRLWA LSLAHAQLSE VLWSMVMRIG LSSRSFGGFI LLALIFFFFA
     VLTVAILLIM EGLSAFLHAL RLHWVEFQNK FYGGQGFKFL PFTFESILDG RFEE
//
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