ID H2LH38_ORYLA Unreviewed; 880 AA.
AC H2LH38;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 67.
DE RecName: Full=Taste receptor type 1 member 3 {ECO:0000256|ARBA:ARBA00040705};
GN Name=tas1r3 {ECO:0000313|Ensembl:ENSORLP00000005292.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000005292.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000005292.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000005292.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000005292.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000005292.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family. TAS1R
CC subfamily. {ECO:0000256|ARBA:ARBA00038492}.
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DR AlphaFoldDB; H2LH38; -.
DR STRING; 8090.ENSORLP00000005292; -.
DR Ensembl; ENSORLT00000005293.2; ENSORLP00000005292.2; ENSORLG00000004226.2.
DR eggNOG; KOG1056; Eukaryota.
DR GeneTree; ENSGT00940000160679; -.
DR HOGENOM; CLU_005389_1_0_1; -.
DR InParanoid; H2LH38; -.
DR TreeFam; TF331269; -.
DR Proteomes; UP000001038; Chromosome 5.
DR Bgee; ENSORLG00000004226; Expressed in mesonephros and 1 other cell type or tissue.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0050916; P:sensory perception of sweet taste; IBA:GO_Central.
DR GO; GO:0050917; P:sensory perception of umami taste; IBA:GO_Central.
DR CDD; cd15290; 7tmC_TAS1R3; 1.
DR CDD; cd06363; PBP1_taste_receptor; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR000068; GPCR_3_Ca_sens_rcpt-rel.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24061; CALCIUM-SENSING RECEPTOR-RELATED; 1.
DR PANTHER; PTHR24061:SF435; TASTE RECEPTOR TYPE 1 MEMBER 3; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF07562; NCD3G; 1.
DR PRINTS; PR00248; GPCRMGR.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 21..42
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 591..614
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 621..648
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 660..683
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 704..722
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 754..775
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 787..808
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 820..840
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 591..857
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
SQ SEQUENCE 880 AA; 97863 MW; DB02F57CBBBCA464 CRC64;
MYEYFMVLSH ICYRSPVSLS ISQLIAVMAL CFLLLAVCWL LRPGCSSPNW FNNISTDLFS
MPGDVKLGGL FPIKEQSNEV SNDLTKLNSV SCDSLNKDGL GRALVMKYAV EEINANSQLL
PGVKLGYKIY NTCRHSAVIV RPALSFLTEK SNGTLSVECN YTDYETDMVA VIGPQSSEMV
TVIGKLLGFF LMPQISFGAT SDKFSDSLVY PSFFRTVPSD IRQVDAMVQL IKKFNWNWVA
VVGSEEEYGQ QGVQQFSKKA EDMGVCVAYQ GLIPIYDDPK PAIQTIINNI QTTEVKVVVV
FSLVSPAVSF FEEVIKKNLT GVWIASSSWA ISDKVYSLPN IERIGTVIGF IDETETLELL
YPFTEVLFKK IHEASPTEKP EDPYNPCPEC WSLSPANVSL VKEESVQRTA FSVYAAVYTV
AHALHKLLEC NSAACKWSSS TRLYPWKLLE VLKEFSVNIS NTSLKFDQNG NPNIGYSVIQ
RSWERNTHLY PSVGSYRSAN LSINESLFKW YTNNSEKPES TCSKNCQIGQ VRRVKGFHSC
CFDCIDCLEG TYQANQDDLQ CTTCPDRQWS SIRSNSCIAP SFDVLEWGAP VSLYLIVAGV
ILLICQGSVF VLFLMHRGTP VVLASGGALT FATLLSLMGA CLSLLLFFGQ PGDVVCHIQL
PLISIFQTVA LSVILAVSLQ LLLVTEFPKS VAPHLRTLRG PGSWVFVLIC CLVQAGLCGW
FVQDVPSLSE YKNNMTINFL HSFLACPVPS EKLAIMQGLN GSMALVSFMC TFMAVKPLHQ
YNLARDITFS TLIYCVTWVI FIPLYTGFST SQSTDHKKRS IAHVSFTLVG ISALVLAYYL
PKCFLLLRKP NLNTPQQFCT FLEGVPPTQT EEEPQPRQEK
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