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Database: UniProt
Entry: H2LIJ6_ORYLA
LinkDB: H2LIJ6_ORYLA
Original site: H2LIJ6_ORYLA 
ID   H2LIJ6_ORYLA            Unreviewed;       847 AA.
AC   H2LIJ6;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   07-JUN-2017, entry version 23.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   Name=LOC101155443 {ECO:0000313|Ensembl:ENSORLP00000005823};
OS   Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae;
OC   Oryziinae; Oryzias.
OX   NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000005823, ECO:0000313|Proteomes:UP000001038};
RN   [1] {ECO:0000313|Proteomes:UP000001038}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hd-rR {ECO:0000313|Proteomes:UP000001038};
RX   PubMed=17554307; DOI=10.1038/nature05846;
RA   Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B.,
RA   Yamada T., Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D.,
RA   Shimada A., Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A.,
RA   Asakawa S., Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K.,
RA   Sugano S., Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F.,
RA   Nomoto H., Nogata K., Morishita T., Endo T., Shin-I T., Takeda H.,
RA   Morishita S., Kohara Y.;
RT   "The medaka draft genome and insights into vertebrate genome
RT   evolution.";
RL   Nature 447:714-719(2007).
RN   [2] {ECO:0000313|Ensembl:ENSORLP00000005823}
RP   IDENTIFICATION.
RC   STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000005823};
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSORLP00000005823}.
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DR   EMBL; BAAF04079442; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BAAF04079443; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 8090.ENSORLP00000005823; -.
DR   Ensembl; ENSORLT00000005824; ENSORLP00000005823; ENSORLG00000004626.
DR   eggNOG; KOG2189; Eukaryota.
DR   eggNOG; COG1269; LUCA.
DR   GeneTree; ENSGT00390000004941; -.
DR   InParanoid; H2LIJ6; -.
DR   OMA; WRACRGF; -.
DR   OrthoDB; EOG091G01BI; -.
DR   TreeFam; TF300346; -.
DR   Proteomes; UP000001038; Chromosome 10.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001038};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    409    433       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    454    472       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    548    569       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    576    601       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    646    665       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    777    801       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED       99    126       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   847 AA;  96245 MW;  363552BFE220E6E5 CRC64;
     MGSMFRSEEV CLVQLFLQSG SAYNCVSELG ELGLVEFRDL NPNVNAFQRK FVGEVRRCEE
     LEKTFTFLEQ EISRSLSPPL QGPLPLPCPM PSAPQPRELI TIEEESERLA RELREVSRNR
     DSLRAQQTQL SQYKGVLNKT HSITASHLLF EKEKPKAPPP ALESHGLFDN RQDVRLSFVA
     GVVHPWKVPS FERLLWRACR GYIIVDFREM DQRLEHPDTG EMVQWTVFLI SFWGDQIGQK
     VKKICDCFHT QTFAYPESPA EREEILQGLN SRIEDIKSVL SQTEAFLQQL LLRSVAILPQ
     WKVRVQKCKA IQMVLNLCSP SVTDKCLIAE AWCPTAKLPE LQSALREGGR KSGSGVDSFY
     NRLPTSTPPP TLFPLNSFTA GFQNIVDAYG VAGYREVNPA VYTIITFPFL FAVMFGDVGH
     GILMSLAALW MVLEEKDPKL KSSNNEIWKM MFGGRYLILL MGLFSIYTGA IYNECFSRSL
     STFASGWHVG PMFDKNIWNA SVLGGNKFLS MDPVVSGVFT SPYPFGIDPV WGMANNKLTF
     LNSYKMKMSV IIGVIHMTFG VCLSFFNYWH FKKMSSVFFV LIPELFFMLC LFGYLVFMVV
     FKWIAYTPAQ SKIAPSILIH FIDMFLFTDN PDNPQLFKGQ LVVQKVLVVL ALCSVPVLLL
     GKPMCQYLTF RRRRRQPLHQ EEDRRPLVTE DGSVNTRQGE VEGGAPAEEE VREDMSQEFD
     VADVFMHQAI HTIEYCLGCI SNTASYLRLW ALSLAHAQLS EVLWTMVMHI ALKWPGYLGS
     AILVLIFAFF AVLTVSILLV MEGLSAFLHA LRLHWVEFQN KFYSGNGYKL VPFSFTSLAT
     KWFNELA
//
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