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Database: UniProt
Entry: H2LIJ8_ORYLA
LinkDB: H2LIJ8_ORYLA
Original site: H2LIJ8_ORYLA 
ID   H2LIJ8_ORYLA            Unreviewed;       846 AA.
AC   H2LIJ8;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   05-JUL-2017, entry version 20.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   Name=LOC101155443 {ECO:0000313|Ensembl:ENSORLP00000005825};
OS   Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae;
OC   Oryziinae; Oryzias.
OX   NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000005825, ECO:0000313|Proteomes:UP000001038};
RN   [1] {ECO:0000313|Proteomes:UP000001038}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hd-rR {ECO:0000313|Proteomes:UP000001038};
RX   PubMed=17554307; DOI=10.1038/nature05846;
RA   Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B.,
RA   Yamada T., Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D.,
RA   Shimada A., Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A.,
RA   Asakawa S., Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K.,
RA   Sugano S., Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F.,
RA   Nomoto H., Nogata K., Morishita T., Endo T., Shin-I T., Takeda H.,
RA   Morishita S., Kohara Y.;
RT   "The medaka draft genome and insights into vertebrate genome
RT   evolution.";
RL   Nature 447:714-719(2007).
RN   [2] {ECO:0000313|Ensembl:ENSORLP00000005825}
RP   IDENTIFICATION.
RC   STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000005825};
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSORLP00000005825}.
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DR   EMBL; BAAF04079442; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BAAF04079443; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSORLT00000005826; ENSORLP00000005825; ENSORLG00000004626.
DR   eggNOG; KOG2189; Eukaryota.
DR   eggNOG; COG1269; LUCA.
DR   GeneTree; ENSGT00390000004941; -.
DR   Proteomes; UP000001038; Chromosome 10.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001038};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    400    424       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    445    463       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    539    560       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    567    592       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    637    656       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    778    802       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED       99    126       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   846 AA;  95765 MW;  6A3645A4156AC943 CRC64;
     MGSMFRSEEV CLVQLFLQSG SAYNCVSELG ELGLVEFRDL NPNVNAFQRK FVGEVRRCEE
     LEKTFTFLEQ EISRSLSPPL QGPLPLPCPM PSAPQPRELI TIEEESERLA RELREVSRNR
     DSLRAQQTQL SQYKGVLNKT HSITASHAPP PALESHGLFD NRQDVRLSFV AGVVHPWKVP
     SFERLLWRAC RGYIIVDFRE MDQRLEHPDT GEMVQWTVFL ISFWGDQIGQ KVKKICDCFH
     TQTFAYPESP AEREEILQGL NSRIEDIKSV LSQTEAFLQQ LLLRSVAILP QWKVRVQKCK
     AIQMVLNLCS PSVTDKCLIA EAWCPTAKLP ELQSALREGG RKSGSGVDSF YNRLPTSTPP
     PTLFPLNSFT AGFQNIVDAY GVAGYREVNP AVYTIITFPF LFAVMFGDVG HGILMSLAAL
     WMVLEEKDPK LKSSNNEIWK MMFGGRYLIL LMGLFSIYTG AIYNECFSRS LSTFASGWHV
     GPMFDKNIWN ASVLGGNKFL SMDPVVSGVF TSPYPFGIDP VWGMANNKLT FLNSYKMKMS
     VIIGVIHMTF GVCLSFFNYW HFKKMSSVFF VLIPELFFML CLFGYLVFMV VFKWIAYTPA
     QSKIAPSILI HFIDMFLFTD NPDNPQLFKG QLVVQKVLVV LALCSVPVLL LGKPMCQYLT
     FRRRRRQPLT CSRTTKPTFP ALTLQQHQEE DRRPLVTEDG SVNTRQGEVE GGAPAEEEEF
     DVADVFMHQA IHTIEYCLGC ISNTASYLRL WALSLAHAQL SEVLWTMVMH IALKWPGYLG
     SAILVLIFAF FAVLTVSILL VMEGLSAFLH ALRLHWVEFQ NKFYSGNGYK LVPFSFTSLV
     HASSAI
//
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