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Database: UniProt
Entry: H2LKN1_ORYLA
LinkDB: H2LKN1_ORYLA
Original site: H2LKN1_ORYLA 
ID   H2LKN1_ORYLA            Unreviewed;      4956 AA.
AC   H2LKN1;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   28-MAR-2018, entry version 43.
DE   SubName: Full=Ryanodine receptor 2b (cardiac) {ECO:0000313|Ensembl:ENSORLP00000006585};
GN   Name=ryr2 {ECO:0000313|Ensembl:ENSORLP00000006585};
OS   Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae;
OC   Oryziinae; Oryzias.
OX   NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000006585, ECO:0000313|Proteomes:UP000001038};
RN   [1] {ECO:0000313|Proteomes:UP000001038}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hd-rR {ECO:0000313|Proteomes:UP000001038};
RX   PubMed=17554307; DOI=10.1038/nature05846;
RA   Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B.,
RA   Yamada T., Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D.,
RA   Shimada A., Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A.,
RA   Asakawa S., Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K.,
RA   Sugano S., Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F.,
RA   Nomoto H., Nogata K., Morishita T., Endo T., Shin-I T., Takeda H.,
RA   Morishita S., Kohara Y.;
RT   "The medaka draft genome and insights into vertebrate genome
RT   evolution.";
RL   Nature 447:714-719(2007).
RN   [2] {ECO:0000313|Ensembl:ENSORLP00000006585}
RP   IDENTIFICATION.
RC   STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000006585};
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
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DR   EMBL; BAAF04026067; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BAAF04026068; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BAAF04026069; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BAAF04026070; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BAAF04026071; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BAAF04026072; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BAAF04026073; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BAAF04026074; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BAAF04026075; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 8090.ENSORLP00000006585; -.
DR   Ensembl; ENSORLT00000006586; ENSORLP00000006585; ENSORLG00000005221.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   InParanoid; H2LKN1; -.
DR   OMA; THEKWSL; -.
DR   OrthoDB; EOG091G00T0; -.
DR   TreeFam; TF315244; -.
DR   Proteomes; UP000001038; Chromosome 15.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 2.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001038};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4287   4305       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4489   4510       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4560   4581       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4696   4716       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4756   4778       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4837   4860       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      101    156       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      163    216       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      224    279       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      285    346       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      350    406       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN     1027   1224       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1349   1555       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     4024   4059       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED     3335   3355       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4956 AA;  560324 MW;  47BF5C1B4607DC57 CRC64;
     MSETGKSEDK FQFLRTGDEV VLQSTFTYQE EHLKLCLAAE GFGSRLCKLE PVSNCKNVPP
     DLSVCGFVLA RCLSVRALQE MLAQSEQAAA ENLKVGDGGS HRTLLYGQAV LFKHSYSGMY
     LSCLSSSQSS TDKLAFDVGL QQDKTGEACW WTVHPSSRQR SEGEKVRVGD DLILVSVASE
     RYLHLIFGTV CDNKSLSDSL IVNAAFHQTL WSVAPICAGG AVAQGYLKGG ETLRLLHSHS
     DACLTVPYTE QGEELQRIIQ YETGSVSTYA RSLWRLEILR VAWSGRHTCW GQPFRLCHVT
     TGRYLGFTEE KGLHLVDRDK ANINTSSFCF RSSKDKPHSG ARTDADGMGH PEIKYGDSVC
     YVQHVYSGLW LTYQADDAKC QMGGTQRKAV LHSEGHMDDG LSLSRSQREE AHTARLIRSS
     LLLFNWFIRK LDGSHQDGNL PSISISMPLM TSSLQDLINY FQSPCDALNQ EDKQNYLNVQ
     KKRQNMFQEE GVMDLVLECI DNLHQYSSAS HFVEAASEGG GGWEVVLNCF YELLAAMIRG
     NRVNCAHFSG SMDWLFSRLD RLEASSGALE VLHCILVESP EALKAIKKGH IESIISFLDK
     HGRINKVLEV LCSLCVCHGV AVRSNQNLIC DSLLPDRDLL LQTRLANQVT SMRPNIFIDP
     GEASSQHRRW YFELVVDHVN TFLTFEPTHL RVGWACTKGY QPRPRGGEGF GGNGVGDDLC
     SYGFDGLHLW SGCVGRRVSS RFPHLLRDND VVSCCLDLTV PCISFRVNGL PVQGMLENFV
     ANGLLYPVVS ISAGVSWKIR ACFLFGGRHG EFRFLPPPGY ASCSEALLPK VKLKVEPCQK
     HVVECEKERK KLFGPLVPVT PVTFSPTPVD ISKVVLPPQL EDIRQKLAEN IHELWVKDKI
     DLGWTYGPMR DESKRHDPCL VEFSKLPEQE KSQNLQTAQD TLRRTLLALG FHIGLTNDKA
     EARAKYTRLH TKYELLGGYR PAPIDFSKVF LSSADEEVVN LLAENDHNVW ARERIKQGWT
     YGVQQDVKAK QSPQLVPYSL LDERTKRTVR EGVRDAVCTL LAFGYSFEPL NQEPGWSLNP
     VHLKKKCRVF RPDKSYAVTT GKWYFEFEVE TDGTMRVGWA RPDCTPDKEL GSDDQAFVFD
     GFEALWHHQG GEALGWPWIR GDVVACLLDM GERSMMVTLN GELLFNQRGS ELAAKDFEIN
     DGFLPIVSVG VNQVGKLNLG HQVDSLKYFK ACGLQEGYKP FAFNMARDPP LWMSWKQSMF
     TSIHDSDQNI QVIRVGGSTD GLSSLRVSRR LLAHHSAGSR MGFYRLSLPV ECAATLRSPA
     EVVLPGGSNS LITSQGWKEQ EDTDSDFEVL MKSAHSSAGS RDELNHKDHG HDKTSKLKQR
     FLLKRNKPSL ASSGSSARLL EDVVIDNDNY DRLIQNSRYY YTVRVLPGQD PFNVWVGWVT
     SDFHHYETTF DTNSVHTVTV TLGDDSGKVQ QSVKRSSCYM VCAGEATGLS QSRRSTGLEI
     GCLIDSSTGL LTFTSNGVEM STFYQVEAQT KLFPAVFVKP TTSNMFQFEL GCVKNAMPLS
     SGLLRSQRRN PTPQCPPRIH VQHLRPVSWT RVPDKALKVL VDQPAEHHGW RIQAFEPQQY
     MGLQIPDEDR CIDVLELSEC RDLQTFHHNT ILLYCSLCSH GNSRVCHALC SHIDQSQILY
     AIQNPYLAGQ LRDAYYQLLI QIYLSSHTTE RLMMNDEYIV PMTGQIRESP SHCALDGGID
     FEGAGIPNND HSTSLKPQIH CSCPCFVRER GMKDESAVVL GCTDSPEIPL DMLKDLTLEM
     VTAGVSAVGH DVRDPAGGNA ELLLVPLLKL LYHLLVIGVF RDEDLGKILW LMEPNEFSII
     AQRSERENEQ ETQGRTTQVE DTIKQGLLQL QLPESVKLEL CHLLSYMCDC QVRQSVEAVM
     AFSEGFVHKL QENQQVRYNQ IMQAFNMSTA LTARRTREFR LPPQEQINML LMFKDDELQE
     NCPCPLETQH LLKDFHHQLK THCAFKATEA DTASEDEDSA EMPLKVRLLR MVESATGLKN
     KPKEKEQCRS QRPKSLNKLI SETMIRWAQE SEIEKPELVR TMFTLLHRQY EGLKGQMEEP
     LSKAYMISQA SVGDTVALLS SLCEIRSLLG IRMGKEEEQL MIRSLGEIMN NKVFYQHPNL
     MRALGMHETV MEVMVNVMEE DESKEVTFSK MVASCCRFLC YFCRISRHNQ GAMFDHLSYL
     LKNSSIGLAL PSMRGSTPLD VAAASVMDNN ELALALREPD LEKVVQYLAG SCLQSCPTLV
     AKGYTDIGWN PVKGERYLDF LRFAVFCNGE SVEENAYEVL RLLIRRPECF GPALRGDGGN
     GLLAAMKEAI MISQDVSMDG PYPSQESQKS LSVSDIHAVQ DKDDDRIQMG HAIMTFYSAL
     IDLLGRCAPE THLIQEGKGE AIRVRAILRS LIPIQDIEGV VSIPLQLPSV SKDGLLMEPD
     LSIVFCPCHK AAMVLFLDRV YGIESQSLLI RLLEVGFLPD IQAAVSLDTV ELGSTDMALA
     LNRYLCGSVL PLLTKFSALL HDLEDHILLV DCLIQGVYRL SGAFSLTKAQ RETAQDCLLA
     LCSKLQASVM QPLLRRLVFD ALHLTDHSTM ALKLLISHYM QRSSYYSQAG RRSDQSLASE
     EELHLSRTLF WGVFKALAKK PYNPQLYELC AQCLVTVAKA LPPDHVESVC LSQMERKSFM
     DTDGHFDPQP VETSNMSVPE RLEFVVNKYA EHTHEKWSLE KFANGWVHGE QLCEDTKVHP
     LLKPYRALVE KEKEAYRWAI KETIKSMLAF GWTIERTKEG DTFDIQACTR GVSQSGQLSF
     EGASTFSPKP LDMSSVTLSW DHCAMAEQLA ENYHNAWAQA KKLELDSKGG GGHPKLVPYD
     TLTTKERTKF RERAQDILKF FLLNGYTVRR DRKTAETDFP ATANCFALTL LQRLLTHTDE
     AQDTMLKLGN APLCCVFSVK YHLWDVNFFI SIVVIPVLEQ YVKSHHLYFI STCLGSSGNR
     SSATKKEKEM IACLFCKVAV FVRQRISHIG DEASAVASCL CVLSQALDAS SQTRTLMKSV
     QESIQTSLHL FFEAAAADLE MTVEKLSETS VSIPQSRGQL ARGVAQALHY TTFILLPTLT
     SLFHHLANQN FGVDFLVGGI QVSCYRILNS LYSFRTTSSI YMEGPVAGAC LAALTGAFPV
     CFLEPSLNQN NPFSIYNTMS ATQIKDQGLP DQVEDVCPLL PSLEEALEQV KELACAGAAA
     HQTHYIHVAE ITLPMLCSYI SHWWCWEPKE LPDSPLFTSV GPQHASDLLG HMLRIFYNHV
     GASHCHWMKQ LAVFSQRIIG SAPVELLKSH FLPLMEKLRK RAEGILREEE QMKAESSCTS
     EGELLMQEKY TLLVRDLYAF YPLLIQFVDC NRARWLKEPI PEAEQLFSMV AEVFIFWAKS
     HHFKWEEQNY VVQNEINNLA SLIKNDKALK FNHREKRMKR KGDRYSAHTS LIVTSMKKLV
     PVGLKGCFQS DQSLITLAKN GFSQKNTEDE IRDQLLSGLL RIQREASISM KQESLYAEQL
     TQHSAVNDAQ KIVDRILEIA RVLYYLDQVE HPERRKKLTR QKVLSRQRKR AVVASLRMTP
     LYNQPRHRAV NLFLFGYTKL WISTGDHKYE EMLIEVLAKG GATKRCEGDR GKIKDREEGA
     RPIDSLLQLI TLFSRSALMD SRHGTDSLFK AYTDIMAKSC RDVDNEEERH VECFEEKEMK
     KQKLLYQQAR LHCRGASEMV LQSISASNGS MGSMIASTLK LGIALLNGGN AAVQQKMLKY
     LREKQDVCFF QSMSGLMRFC SVLDPNAFER QKKAEGLGLT MAESSGGKVM PDKDLTCDLF
     RFLQLLCEGH NADFQDYLRT QTGNNTTVNI IISTVDYLLR VQESISDFYW YYSGKDVVDA
     EGQLNFSKAI EVAKQVFNTL TEYIQGPCTG NQQSLAHSRL WDAVVGFLHI FAHLQMKLSQ
     DSSQNELLKE LMDLQKDMVV FLLSMLEAGN VINGTIGKQM VDMLVESSGN VEMILNFFNM
     FLKLKDLTSS ELFREYDPDC KGNISKKDFH KVMEYCNHFS QAEIHFLLSC METNESEIVD
     YADFVDRFHE PAKDIGFSIT VLLTNLSEHM PKDPRLKTFL EMAECVLTYF QPCLGRIEIL
     GSGKRFERIY FEISDYSRTQ WEKPQVKESK RQFIFDVVNE GGEMEKMEMF VNFCEDTIFE
     MQLAAQISGS NAGEKCSGKE GEDTKHGDDE ALDSKRMSLV DQWWLFLSSV LSVKKTLMKM
     SLKDIFISAF LLFRLICLTQ IQCINFVIRS ILYVLYVAFV SGGLIEKAKK MRMSDLLGGI
     LEPTLDEVME GPSGVNRLKL SEIGQMAALT SPREVDALSD IFGLKLKKEG GQYRLVSKDL
     SASLTDLFQT ASRTTVTTEI FEQHHSVQFR EQVDTDETAK DGNMIQLKHT EKMHKVCRNE
     KSENMKPETN LTNKGCSNKS KDSHGQHFAL WETISSQNKS LLSFFARNFY TMRFVALFVT
     FAINFILLFY KVASMPASKG EEVRITSVDR EDLDSVIEED SRGRDYFVLE ESSGWMEPSL
     HLLAFAHTVI SFCCIIGYYY LKVPLLIFKR EKEVARKLEF DGLYVTKQPS EEDIKGQWDR
     LVINTPSFPS NYWDKFVKRK VMDKYGDLCG SEKISDLLGL DKAALDFSSV RKDMMRVKKD
     TAWAALFRSI DVKYQIWKLG VVFTDNCFLY LTWYMLVSSL GHYNNFFFAA HLLDIAMGFK
     TLRTILSSVT HNGKQLVLTV GLLAVVVYLY TVVAFNFFRK FYNKSDDIDT QDMKCNDMLT
     CYMFHMYVGV RAGGGIGDEI EDPAGDEFEV ERIIFDITFF FFVIVILLAI IQGLIIDAFG
     ELRDQQEQVK EDMETKCFIC GIGSEYFDAV PHGFETHTLQ EHNLANYLFF LMYLINKDET
     EHTGQESYVW KMYQERCWEF FPVGDCFRKQ YEDQLG
//
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