ID H2LQ14_ORYLA Unreviewed; 1504 AA.
AC H2LQ14;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=Bromodomain containing 4 {ECO:0000313|Ensembl:ENSORLP00000008150.2};
GN Name=brd4 {ECO:0000313|Ensembl:ENSORLP00000008150.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000008150.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000008150.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000008150.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000008150.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000008150.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR RefSeq; XP_011476373.1; XM_011478071.1.
DR STRING; 8090.ENSORLP00000008150; -.
DR Ensembl; ENSORLT00000008151.2; ENSORLP00000008150.2; ENSORLG00000006490.2.
DR GeneID; 101158947; -.
DR CTD; 23476; -.
DR eggNOG; KOG1474; Eukaryota.
DR GeneTree; ENSGT00940000162790; -.
DR HOGENOM; CLU_001499_0_3_1; -.
DR InParanoid; H2LQ14; -.
DR OrthoDB; 152619at2759; -.
DR TreeFam; TF317345; -.
DR Proteomes; UP000001038; Chromosome 8.
DR Bgee; ENSORLG00000006490; Expressed in gastrula and 14 other cell types or tissues.
DR GO; GO:0000785; C:chromatin; IBA:GO_Central.
DR GO; GO:0000793; C:condensed chromosome; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003682; F:chromatin binding; IEA:Ensembl.
DR GO; GO:0070577; F:lysine-acetylated histone binding; IBA:GO_Central.
DR GO; GO:0006338; P:chromatin remodeling; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IBA:GO_Central.
DR GO; GO:0002574; P:thrombocyte differentiation; IEA:Ensembl.
DR CDD; cd05497; Bromo_Brdt_I_like; 1.
DR CDD; cd05498; Bromo_Brdt_II_like; 1.
DR Gene3D; 1.20.1270.220; -; 1.
DR Gene3D; 1.20.920.10; Bromodomain-like; 2.
DR InterPro; IPR031354; BRD4_CDT.
DR InterPro; IPR043508; Bromo_Brdt_I.
DR InterPro; IPR043509; Bromo_Brdt_II.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR018359; Bromodomain_CS.
DR InterPro; IPR027353; NET_dom.
DR InterPro; IPR038336; NET_sf.
DR PANTHER; PTHR22880:SF143; BROMODOMAIN-CONTAINING PROTEIN 4; 1.
DR PANTHER; PTHR22880; FALZ-RELATED BROMODOMAIN-CONTAINING PROTEINS; 1.
DR Pfam; PF17035; BET; 1.
DR Pfam; PF17105; BRD4_CDT; 1.
DR Pfam; PF00439; Bromodomain; 2.
DR PRINTS; PR00503; BROMODOMAIN.
DR SMART; SM00297; BROMO; 2.
DR SUPFAM; SSF47370; Bromodomain; 2.
DR PROSITE; PS00633; BROMODOMAIN_1; 2.
DR PROSITE; PS50014; BROMODOMAIN_2; 2.
DR PROSITE; PS51525; NET; 1.
PE 4: Predicted;
KW Bromodomain {ECO:0000256|ARBA:ARBA00023117, ECO:0000256|PROSITE-
KW ProRule:PRU00035}; Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 140..212
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT DOMAIN 457..529
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT DOMAIN 714..796
FT /note="NET"
FT /evidence="ECO:0000259|PROSITE:PS51525"
FT REGION 63..121
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 243..317
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 346..438
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 550..605
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 622..709
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 787..1052
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1077..1485
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 94..110
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 260..281
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 282..309
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 346..365
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 375..395
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 396..419
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 424..438
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 577..592
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 636..650
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 678..694
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 800..835
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 854..869
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 897..931
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 955..972
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1077..1192
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1215..1245
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1267..1281
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1282..1305
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1309..1326
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1338..1360
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1361..1423
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1425..1447
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1466..1484
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1504 AA; 166387 MW; 944B59BB8AE3C2A3 CRC64;
MDYKMHAKSN DLLDFQKLDA LLEKIAHSVS VKRESSEECN GISGALSVES VSGPRLNWCP
ANTTAPASAP APASSPGPEP TPLPFRMGDG LETAQMSGSG QGQAQQGGNP PPPECINPNR
PKRQTNQLQY LLKVVVKALW KHHFSWPFQA PVDAIKLNLP DYYTIIHTPM DLGTIKKRLE
NSYYWNAQEC IQDFNTMFTN CYIYNKPGDD IVLMAEALEK VFLQKVSEMP QEEIEIVVMT
GKGRGRGRRD GGLNLKPGGI IDSPSTTPQT RGLSSLPTPP QSRGPLQGPP SLPPQPLLQA
LPPHVPSTLP SHAPQLGAPY SMSQLDCAPQ LPNLLSVPLA GQTSLPPASI QGPAPILQTP
VTMTKQRKSQ KRKADTTTPT ANDQLNESSP AESKSGKTLP RRESTRPTKL MKKDAPDSQH
HIGMGTGLGS SSGGLSPRPQ DQLGYCAALV REMLSKKHAA YAWPFYKPVD VDALGLHDYH
DIIKHPMDLS TIKAKLENRQ YRDPQEFAAD VRLMFSNCYK YNPPDHEVVA MARKLQDVFE
MRFAKMPDEP ESKHVVSVPP PSLHHPAPVK PQPPMAHIAS SSDSSSDSSS ESESSTDDPE
EERAQRLAEL QEQLKAVHEQ LAALSQPQAS KPKRKEKEKK EKKKEKHKKK SSMLGLVDEI
QDPPPVSQLS KKTKTININK EIVSKKKPSK KEVMKSNHPS SLQPVPSLEE ELGSLVTGEK
CKPMTYEEKR QLSLDINKLP GDKLGRVVHI IQSREPSLKN SNPDEIEIDF ETLKPSTLRE
LERYVSTCLK KKKKTTVEKA VESMATSKKA GSSSDSSGSS SDSEAEGTGT IKQQKKKTPS
MKEGKKPHPH AQMGPAQPGL PPQVPPPQPS SQMKQQQQRQ PSPEGFMAPP PVAPLESSQL
LETNFETLPQ FNQPLLLMNN TGNSSSPAPP HLNPHSAEPV SPETHPFLNQ HPILPSPALH
SSLPQQPSRP SNKAAPLHPK PPQQQPAAPQ QQQLQPQSAP PPQHQLPAQL LHPSQPMHQR
PLSPPTLTPQ GLLSSQPPQL LLEDDEEPGS TTPINQVQLY LQQLQQAHQA PQTLQSLQAQ
VRQTQKQQPG QTSLLQSGPG QTPISSQTSL PPPQLPVQSQ APPTSLHQAL PPQMSLHQGR
HLQHTQQQQP PSQPHQVNFQ QGSGHSVLSQ VSQNKSSMPP SKTQQIIQHQ QPSPRPIKAD
PYSAAHIRDN PSPLMMHSPQ MSQYPPVSHL SPPHNMQPKK QRSSGSQGGV KEEKLPPSPM
VREQFNPAMR PEHHKHPESK PSQQNVKSID SSRPVIRTSE PSGPPASLQD KDKFKHESKT
SSAPKKVQDV KLKNMGSWAS LAQKSTSTTS SAVKSSSDSF EQFRRVAREK EEREKALKAQ
AEQAEKDRLR REQDKLRGRD EEDVMEPSRR VHEEPRRRLE QTHVQAPLHQ PQQLQVQQET
QPTVVQQSTQ PPTPPQPSSQ NSLDQQRELA RRKEQERRRR EAMAATIDMN FQSDLMAIFE
ENLF
//
