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Database: UniProt
Entry: H2LR05_ORYLA
LinkDB: H2LR05_ORYLA
Original site: H2LR05_ORYLA 
ID   H2LR05_ORYLA            Unreviewed;       850 AA.
AC   H2LR05;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   07-JUN-2017, entry version 23.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   Name=atp6v0a2 {ECO:0000313|Ensembl:ENSORLP00000008502};
OS   Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae;
OC   Oryziinae; Oryzias.
OX   NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000008502, ECO:0000313|Proteomes:UP000001038};
RN   [1] {ECO:0000313|Proteomes:UP000001038}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hd-rR {ECO:0000313|Proteomes:UP000001038};
RX   PubMed=17554307; DOI=10.1038/nature05846;
RA   Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B.,
RA   Yamada T., Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D.,
RA   Shimada A., Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A.,
RA   Asakawa S., Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K.,
RA   Sugano S., Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F.,
RA   Nomoto H., Nogata K., Morishita T., Endo T., Shin-I T., Takeda H.,
RA   Morishita S., Kohara Y.;
RT   "The medaka draft genome and insights into vertebrate genome
RT   evolution.";
RL   Nature 447:714-719(2007).
RN   [2] {ECO:0000313|Ensembl:ENSORLP00000008502}
RP   IDENTIFICATION.
RC   STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000008502};
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSORLP00000008502}.
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DR   EMBL; BAAF04060964; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 8090.ENSORLP00000008502; -.
DR   Ensembl; ENSORLT00000008503; ENSORLP00000008502; ENSORLG00000006769.
DR   eggNOG; KOG2189; Eukaryota.
DR   eggNOG; COG1269; LUCA.
DR   GeneTree; ENSGT00390000004941; -.
DR   OMA; TIPSFMN; -.
DR   OrthoDB; EOG091G01BI; -.
DR   TreeFam; TF300346; -.
DR   Proteomes; UP000001038; Chromosome 9.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001038};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    409    433       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    454    472       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    548    566       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    578    601       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    644    667       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    778    803       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED      101    128       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   850 AA;  97785 MW;  76DE68860C7098E5 CRC64;
     MGSFLRGDEM CLAQLFLQSG SAYDCISELG ELGLVEFRDL NPNVNAFQRK YVNEIKKCEE
     MERILGYLLR EIKKADISLP DRDVNPVAPS PKNVMSIMEQ LQRFELELGE VTRNKERLQK
     NLLELTEYTH MLRISRDFVQ RPIEREPLQT QYEEFPFLEK DTVMDYSSMQ RLGAKLGFFS
     GLIQRAKIEA FERMLWRVCK GYTILSYAEV EEYLQDPDKG EAVKCVVFLI SYWGDQIGQK
     VKKICDCYHC HLYPYPNSNE ERIDVMEGLK TRIQDLHTVL HRTEDYLKQV LVKASESVHS
     WVVQVKKMKA IYYILNLCSF DVTNKCLIAE VWCPVSDIPT LRRSLEDGSK KSGSNISSFV
     NRIPTTDTPP TLIRTNKFTS GFQNIVDAYG VGTYREVNPA PFTVITFPFL FAVMFGDLGH
     GAIMALFAGW MVFYENNRKL KNTRNEIWNT FFEGRYIILM MGIFSIYTGL IYNDCFSKSL
     NIFGSGWSVR PMFQTGEWTN DVLRGNHFLT LNPNIAGVFT GPYPLGIDPI WNLASNRLTF
     LNSYKMKMSV IVGVIHMSFG VILSTYNHVY FKKKYNLYLV FLPELLFLLC LFGYLVFMIF
     YKWLAFSAED SSNAPSILIH FINMFLMQGE EVQPLYTGQH GLQVFLVVIA VFSVPVLLLG
     KPLYLYWLQH GRQHLGMYRQ GYERVRRSSD EELYLLRTHD EEEGSSYSDL SGSGEKTTEQ
     FNLADEFLHQ AIHTIEYCLG CISNTASYLR LWALSLAHAQ LSEVLWTMVM RVGLRMDTAL
     GVLFLVPVFG LFAVLTVSIL LVMEGLSAFL HALRLHWVEF QNKFYSGTGV KFCPFSFSAL
     PSSFENDGLL
//
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