ID H2LRC5_ORYLA Unreviewed; 564 AA.
AC H2LRC5;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Cytochrome P450, family 2, subfamily U, polypeptide 1 {ECO:0000313|Ensembl:ENSORLP00000008624.2};
GN Name=LOC101167098 {ECO:0000313|Ensembl:ENSORLP00000008624.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000008624.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000008624.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000008624.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000008624.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000008624.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the cytochrome P450 family.
CC {ECO:0000256|ARBA:ARBA00010617, ECO:0000256|RuleBase:RU000461}.
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DR AlphaFoldDB; H2LRC5; -.
DR STRING; 8090.ENSORLP00000008624; -.
DR Ensembl; ENSORLT00000008625.2; ENSORLP00000008624.2; ENSORLG00000006861.2.
DR eggNOG; KOG0156; Eukaryota.
DR GeneTree; ENSGT00940000157714; -.
DR HOGENOM; CLU_001570_22_0_1; -.
DR InParanoid; H2LRC5; -.
DR TreeFam; TF352043; -.
DR Proteomes; UP000001038; Chromosome 1.
DR Bgee; ENSORLG00000006861; Expressed in liver and 13 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0020037; F:heme binding; IBA:GO_Central.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0016712; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; IBA:GO_Central.
DR GO; GO:0008395; F:steroid hydroxylase activity; IBA:GO_Central.
DR GO; GO:0006082; P:organic acid metabolic process; IBA:GO_Central.
DR GO; GO:0006805; P:xenobiotic metabolic process; IBA:GO_Central.
DR Gene3D; 1.10.630.10; Cytochrome P450; 1.
DR InterPro; IPR001128; Cyt_P450.
DR InterPro; IPR017972; Cyt_P450_CS.
DR InterPro; IPR002401; Cyt_P450_E_grp-I.
DR InterPro; IPR008069; Cyt_P450_E_grp-I_CYP2D-like.
DR InterPro; IPR036396; Cyt_P450_sf.
DR PANTHER; PTHR24300:SF281; CYTOCHROME P450 2U1; 1.
DR PANTHER; PTHR24300; CYTOCHROME P450 508A4-RELATED; 1.
DR Pfam; PF00067; p450; 1.
DR PRINTS; PR00463; EP450I.
DR PRINTS; PR01686; EP450ICYP2D.
DR PRINTS; PR00385; P450.
DR SUPFAM; SSF48264; Cytochrome P450; 1.
DR PROSITE; PS00086; CYTOCHROME_P450; 1.
PE 3: Inferred from homology;
KW Heme {ECO:0000256|ARBA:ARBA00022617, ECO:0000256|RuleBase:RU000461};
KW Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|RuleBase:RU000461};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU000461};
KW Monooxygenase {ECO:0000256|RuleBase:RU000461};
KW Oxidoreductase {ECO:0000256|RuleBase:RU000461};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..32
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 244..262
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 564 AA; 63679 MW; 9E0F56CDFFCFA083 CRC64;
MVSSSFGLIW SSVLSLSNLL TSLLFLLVYY LVRFYQKQRT IYKNIPPGPK PWPVVGNFGN
FFVPPSVRTK IAGQPNSTNA IEIEALRQQA TVFGNIHSLF IGGQLIVVLH GFHLIRDALL
NQPEVFSDRP DIPLVTILTK RKGIVFAPYG PVWRKQRKFC HTTLRSFGLG KLSLEPCIQR
GLAGVKAELL RLNEERGSAG VDPATLIGNS VSNVICSLIL GQCFHHHDVE FRTMIRLMEH
GLKICINSPA VLINIFPLLY YLPFGVFKEL RQVERDITAF LKRIIAKHRD TLDPDNPRDL
TDMYLIEMLT QQAAGVEDSS FTDDYLFYVI GDLFIAGTDT TTNSILWFLL YMILHPDVQD
KAQAEIDGVV GKHRVPSVTD KGSLPFTEAT IMEVQRLHSV VPLAIPHMTS ETTVFRGYTI
PKGTVIFPNL WSVHRDPTLW EDADSFNPSR FLDNEGNLLR KEYFIPFGIG RRVCMGEQLA
KMELFLTVTT LLQAFKFRHP EGNPPPTVKE RFGLTMAPCP FSVCVTPRDQ KLFNHEYAAD
ALTPEFISSN KKKSLFAIKD AKLR
//
