GenomeNet

Database: UniProt
Entry: H2LWE6_ORYLA
LinkDB: H2LWE6_ORYLA
Original site: H2LWE6_ORYLA 
ID   H2LWE6_ORYLA            Unreviewed;      2423 AA.
AC   H2LWE6;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 2.
DT   24-JAN-2024, entry version 78.
DE   RecName: Full=histone acetyltransferase {ECO:0000256|ARBA:ARBA00013184};
DE            EC=2.3.1.48 {ECO:0000256|ARBA:ARBA00013184};
GN   Name=LOC101155770 {ECO:0000313|Ensembl:ENSORLP00000010434.2};
OS   Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC   Oryzias.
OX   NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000010434.2, ECO:0000313|Proteomes:UP000001038};
RN   [1] {ECO:0000313|Ensembl:ENSORLP00000010434.2, ECO:0000313|Proteomes:UP000001038}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000010434.2,
RC   ECO:0000313|Proteomes:UP000001038};
RX   PubMed=17554307; DOI=10.1038/nature05846;
RA   Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA   Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA   Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA   Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA   Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA   Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT   "The medaka draft genome and insights into vertebrate genome evolution.";
RL   Nature 447:714-719(2007).
RN   [2] {ECO:0000313|Ensembl:ENSORLP00000010434.2}
RP   IDENTIFICATION.
RC   STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000010434.2};
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR   STRING; 8090.ENSORLP00000010434; -.
DR   Ensembl; ENSORLT00000010435.2; ENSORLP00000010434.2; ENSORLG00000008296.2.
DR   eggNOG; KOG1778; Eukaryota.
DR   GeneTree; ENSGT00940000155364; -.
DR   HOGENOM; CLU_000162_2_0_1; -.
DR   InParanoid; H2LWE6; -.
DR   OrthoDB; 5490807at2759; -.
DR   TreeFam; TF101097; -.
DR   Proteomes; UP000001038; Chromosome 8.
DR   Bgee; ENSORLG00000008296; Expressed in testis and 15 other cell types or tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0000123; C:histone acetyltransferase complex; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR   GO; GO:0005667; C:transcription regulator complex; IBA:GO_Central.
DR   GO; GO:0031490; F:chromatin DNA binding; IBA:GO_Central.
DR   GO; GO:0140297; F:DNA-binding transcription factor binding; IEA:UniProt.
DR   GO; GO:0004402; F:histone acetyltransferase activity; IBA:GO_Central.
DR   GO; GO:0003713; F:transcription coactivator activity; IBA:GO_Central.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0050896; P:response to stimulus; IEA:UniProt.
DR   GO; GO:0048511; P:rhythmic process; IEA:UniProtKB-KW.
DR   CDD; cd05495; Bromo_cbp_like; 1.
DR   CDD; cd20910; NCBD_CREBBP-p300_like; 1.
DR   CDD; cd15647; PHD_CBP; 1.
DR   CDD; cd15802; RING_CBP-p300; 1.
DR   CDD; cd02337; ZZ_CBP; 1.
DR   Gene3D; 2.10.110.40; -; 1.
DR   Gene3D; 3.30.60.90; -; 1.
DR   Gene3D; 1.20.920.10; Bromodomain-like; 1.
DR   Gene3D; 1.10.246.20; Coactivator CBP, KIX domain; 1.
DR   Gene3D; 1.10.1630.10; Nuclear receptor coactivator, CREB-bp-like, interlocking domain; 1.
DR   Gene3D; 1.20.1020.10; TAZ domain; 2.
DR   Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR   InterPro; IPR001487; Bromodomain.
DR   InterPro; IPR036427; Bromodomain-like_sf.
DR   InterPro; IPR018359; Bromodomain_CS.
DR   InterPro; IPR031162; CBP_P300_HAT.
DR   InterPro; IPR013178; Histone_AcTrfase_Rtt109/CBP.
DR   InterPro; IPR003101; KIX_dom.
DR   InterPro; IPR036529; KIX_dom_sf.
DR   InterPro; IPR009110; Nuc_rcpt_coact.
DR   InterPro; IPR014744; Nuc_rcpt_coact_CREBbp.
DR   InterPro; IPR037073; Nuc_rcpt_coact_CREBbp_sf.
DR   InterPro; IPR010303; RING_CBP-p300.
DR   InterPro; IPR038547; RING_CBP-p300_sf.
DR   InterPro; IPR035898; TAZ_dom_sf.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   InterPro; IPR000197; Znf_TAZ.
DR   InterPro; IPR000433; Znf_ZZ.
DR   InterPro; IPR043145; Znf_ZZ_sf.
DR   PANTHER; PTHR13808; CBP/P300-RELATED; 1.
DR   PANTHER; PTHR13808:SF56; HISTONE ACETYLTRANSFERASE; 1.
DR   Pfam; PF00439; Bromodomain; 1.
DR   Pfam; PF09030; Creb_binding; 1.
DR   Pfam; PF08214; HAT_KAT11; 1.
DR   Pfam; PF02172; KIX; 1.
DR   Pfam; PF06001; RING_CBP-p300; 1.
DR   Pfam; PF02135; zf-TAZ; 2.
DR   Pfam; PF00569; ZZ; 1.
DR   PRINTS; PR00503; BROMODOMAIN.
DR   SMART; SM00297; BROMO; 1.
DR   SMART; SM01250; KAT11; 1.
DR   SMART; SM00551; ZnF_TAZ; 2.
DR   SMART; SM00291; ZnF_ZZ; 1.
DR   SUPFAM; SSF47370; Bromodomain; 1.
DR   SUPFAM; SSF47040; Kix domain of CBP (creb binding protein); 1.
DR   SUPFAM; SSF69125; Nuclear receptor coactivator interlocking domain; 1.
DR   SUPFAM; SSF57850; RING/U-box; 1.
DR   SUPFAM; SSF57933; TAZ domain; 2.
DR   PROSITE; PS00633; BROMODOMAIN_1; 1.
DR   PROSITE; PS50014; BROMODOMAIN_2; 1.
DR   PROSITE; PS51727; CBP_P300_HAT; 1.
DR   PROSITE; PS50952; KIX; 1.
DR   PROSITE; PS50134; ZF_TAZ; 2.
DR   PROSITE; PS01357; ZF_ZZ_1; 1.
DR   PROSITE; PS50135; ZF_ZZ_2; 1.
PE   4: Predicted;
KW   Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW   Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW   Biological rhythms {ECO:0000256|ARBA:ARBA00023108};
KW   Bromodomain {ECO:0000256|ARBA:ARBA00023117, ECO:0000256|PROSITE-
KW   ProRule:PRU00035}; Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW   ProRule:PRU00203}; Methylation {ECO:0000256|ARBA:ARBA00022481};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PROSITE-ProRule:PRU00203};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU00228}.
FT   DOMAIN          307..393
FT                   /note="TAZ-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50134"
FT   DOMAIN          544..623
FT                   /note="KIX"
FT                   /evidence="ECO:0000259|PROSITE:PS50952"
FT   DOMAIN          1045..1117
FT                   /note="Bromo"
FT                   /evidence="ECO:0000259|PROSITE:PS50014"
FT   DOMAIN          1275..1652
FT                   /note="CBP/p300-type HAT"
FT                   /evidence="ECO:0000259|PROSITE:PS51727"
FT   DOMAIN          1654..1702
FT                   /note="ZZ-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50135"
FT   DOMAIN          1717..1798
FT                   /note="TAZ-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50134"
FT   ZN_FING         307..393
FT                   /note="TAZ-type"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00203"
FT   ZN_FING         1717..1798
FT                   /note="TAZ-type"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00203"
FT   REGION          1..26
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          44..70
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          102..195
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          418..439
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          456..516
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          624..665
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          779..1025
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1508..1566
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1825..1928
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1985..2017
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2114..2192
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2278..2304
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2323..2395
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        114..160
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        650..665
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        779..806
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        821..862
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        863..892
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        893..920
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        945..1012
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1508..1523
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1540..1554
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1850..1866
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1867..1888
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1889..1903
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2114..2171
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2278..2300
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2337..2371
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2379..2395
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   2423 AA;  266062 MW;  77D119F3A1F4B940 CRC64;
     MADNLLDAVP PMAKRPKLNS PLSGSDGPDL VSLFDLENDL PDELIPNGET GLSTISGPGG
     GGPGHNSVIP DAAAKHKQLS ELLRPGSSST LGGTFNSSIG SQLGSVLGKG PLGQGSPNHQ
     NSPQGQKVGV PSGQSNGSTG MGFNQALLNS GQSHGMMGQT GQVMNGAMGP MGRGRPGMQY
     QGQGMQGTQV SPGPGVGGSA LAETLTQGGP QMAVHNTMNA QQSGNMNKMA MSGAQFSQQY
     GPTGVQQMGS AVNPQLQSKA AISNNLPQFH AADLKGVGNV PNMMQQQVAS MGMVAGAGGV
     SGGPTADPEK RKLIQQQLVL LLHAHKCQRR EQANGEVRSC ALPHCRTMKN VLNHMTHCQA
     GKSCQVAHCA SSRQIISHWK NCTRHDCPVC LPLKNASDKR NQQPLLSSPG ANLQKAINTA
     GPSQPSATTI SSGTSHIDPS SMQRAYAALG LPYGNQSSAQ VQGQGPAQQN PPGTQHQQLR
     NMNALGANQM NQMPGNMGTS STDQSGLHSD SSLPSTLHNQ LMTDGSVLGG IGNLPTATPL
     SATGVRKAWH EHVTQDLRTH LVHKLVQAIF PTPDPAALKD RRMDNLVAYA RKVEGDMYES
     ANSRDEYYHF LAEKIYKIQK ELEEKRRSRE KDRNVVATAR SQQPGLPQPN TMCPAQPVRP
     PNGPVSMPNM PNQMMNRMQV PQGINHFNPM TMQNPQMPQA PMGARAPSPM SHPQQMNMPP
     VQPMGVSPTG ISHNQGVMSS HTNNMVSQQP NQVQFMPQGQ FQSSTSGAMN VNVGSGQAMS
     QAAAAQQPQN SSLPMNALGS LGSQLPPGPT AQPPLGTTPP PNASATLQPH QQQTPHAAAQ
     AQVPRPSTPS SSMGSSFTPS HIPNSLPRPP STMGPPSVPS QPVTPQQPQP EPPSQMQQCT
     SVQAQHPSTP LSQAAASVDN RVPTPGSVAE PGSHPVLPDM NGTEVKSVKN EEDENCIEKK
     PDDIKMEQDD ETKPSVVKKE EPDAAKPKQE PMEAEPAIKT EVKTEPKEEE EGGANSTSTS
     QNHKKIFKPE ELRQALMPTL EALYRQDPES LPFRQPVDPM LLGIPDYFDI VKNPIDLSTI
     KRKLDTGQYQ EPWQYVEDVW LMFNNAWLYN RKTSRVYKYC TKLAEVFEVE IDPVMQSLGY
     CCGRKYEFSP QTLCCYGKQL CTISRDGTYY SYQNSSPKYG LIADRYHFCE KCFNEIQGNS
     VTLGDDPAQP QTVISKEQFE KKKNDTLDPE PFVECKDCER KMHQICVLHY EVIWPSGFIC
     DNCLKKSGKT KKENKFSARR LQTTRLGTYI EDRVNKYLKR QNHPEAGEVF VRVVASSDKS
     VDVKPGMKSR FVDSGEMMEN FPYRTKALFA FEEIDGVDVC FFGMHVQEYG SDCPFPNTRR
     VYISYLDSVH FFKPRLLRTA VYHEILIGYL EYVKKLGYVM GHIWACPPSE GDDYIFHCHP
     PDQKIPKPKR LQEWYRKMLD KAFAERILHD YKDIFKQATE DRLTSANELP YFEGDFWPNV
     LEESIKELEQ EEEERKKEEN TASSETTEGA QADSKNAKKK NNKKTNKNKS SLSRANKKKP
     GMPNVANDLS QKLYATMEKH KEVFFVIHLH AGPVINTLPP IMDPDPLLTC DLMDGRDAFL
     TLARDKHWEF SSLRRCKWST MCMLVELHNQ GQDRFVYTCN ECKHHVETRW HCTVCEDYDL
     CINCYKTKGH EHQMVKWGLG LDDDSNGQGG EASKSPQENR RLSIQRCIQS LVHACQCRNA
     NCSLSSCQKM KRVVQHTKGC KRKTNGGCPV CKQLIALCCY HAKHCQENKC PVPFCLNIKQ
     KLHQQQLQHR LHQAQMMRRR MATMAGRGMP MPSPPTSTAL DTPNSLQQPN TPQTPQPMPN
     QPQQQPPNPA NIAQGFPGNG RGSQPTTPVP QGKPGPPSSP LHQQLSPMPN MPHQQQPPPP
     QQQQQLLAAQ KVAHEIQMVA KAKQLQTNYA MNGMHMNHSR MMGPGPNQMQ MVQGPRGPQV
     MPAMQQGQWN PGMQKPQGSQ PQVPPQQGPM VSQQAQGTPM LQPGQLMQRP MMPQQHGLQM
     PGVMPSQMPS QQGMTQQQQN MPRGIPSNIT QNALQELLHF LKSPSSPHQQ QQVLTILKSN
     PHLMAAFIKQ RTAKYQASQQ PQQQQQQQAQ QQQNPQAMMG SQAGMQVMSS MANQVPRPGI
     SPQQQPRQPA GPQGMMSIGP QGQMMNPAQN GNPQLYRRQQ MFRMQQMQSQ GGLNQVHGQF
     PPQQTGQANF SQICMQQQMT MQGGGGPMSQ LPPTSQMGQP GMGVDSSRMV LQQRLLQPQQ
     MKQQMGSPAQ ANSMSPQPHM LQGQAPGVAH LQGQTMANTL GNQVRSPAPV QSPRPPSQQA
     PHSGSSPRIQ PHPSPQHAAL HSNSPHPSLA PMSGSMEQGH MGTPEQSAML PQLNTPNRGA
     LGNDMGMVGD TTGDTLEKFV EGL
//
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