ID H2LY37_ORYLA Unreviewed; 739 AA.
AC H2LY37;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=SRY-box transcription factor 5 {ECO:0000313|Ensembl:ENSORLP00000011049.2};
GN Name=sox5 {ECO:0000313|Ensembl:ENSORLP00000011049.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000011049.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000011049.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000011049.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000011049.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000011049.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR AlphaFoldDB; H2LY37; -.
DR Ensembl; ENSORLT00000011050.2; ENSORLP00000011049.2; ENSORLG00000008803.2.
DR eggNOG; KOG0528; Eukaryota.
DR GeneTree; ENSGT00940000156122; -.
DR HOGENOM; CLU_018522_0_0_1; -.
DR TreeFam; TF320471; -.
DR Proteomes; UP000001038; Chromosome 23.
DR Bgee; ENSORLG00000008803; Expressed in intestine and 12 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR CDD; cd22042; HMG-box_EGL13-like; 1.
DR Gene3D; 1.10.30.10; High mobility group box domain; 1.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR PANTHER; PTHR45789; FI18025P1; 1.
DR PANTHER; PTHR45789:SF3; TRANSCRIPTION FACTOR SOX-5; 1.
DR Pfam; PF00505; HMG_box; 1.
DR SMART; SM00398; HMG; 1.
DR SUPFAM; SSF47095; HMG-box; 1.
DR PROSITE; PS50118; HMG_BOX_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00267}; Nucleus {ECO:0000256|PROSITE-ProRule:PRU00267};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038}.
FT DOMAIN 534..602
FT /note="HMG box"
FT /evidence="ECO:0000259|PROSITE:PS50118"
FT DNA_BIND 534..602
FT /note="HMG box"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00267"
FT REGION 1..128
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 341..389
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 394..413
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 505..534
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 664..739
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 184..264
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 433..460
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 59..93
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 341..377
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 399..413
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 667..686
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 697..715
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 716..730
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 739 AA; 81112 MW; 8408ECD16C34D780 CRC64;
LLTEDALCWS MSSKRPASPY GGTDGEVTMA TSRQRVEDEE NEGLGGVIHL PLASYCGKVS
PRSPSNRNLE SPANTEHDGS KGSSLSPYPQ HNATSPGKEE GVGGGRPCSD GGFGMGPLGT
PERRKGSLAD VVDTLKQRKM EELIKNEPEE APSIERLLSK DWKDKLLAMG SGHIAEIKGT
PDSLAEKERQ LMGMIGQLSS LREQLLAAHE EQKKLAASQM EKQRQQMELA KQQQDQIARQ
QQQLLQQQHK INLLQQQIQQ VQGQLPPLMI PVFPPDQRTL AAAAAQQGFL MPPGFNYKPG
CSDPYPLQLI PTTMAAATPG LGPLQLQQLY AAQLAAMQVS PGAKQQHGGN LPPQANLGTH
SPTTNTHPQS DKSRSPPPAN KTKVPAAAAA ATKLGPISSM KHSAPSSIGG PPSRVSSIDL
LSSLSSTAYM NDHEAVTKAF AEARQMKEQL KREQQVLDAK VAAVSNLGLN NGRSDKDKAA
LESLSQQLKQ QAEDKFSHAM LDFTMSGDSD GSPSVSDSRI FRESRGRSNN EPHIKRPMNA
FMVWAKDERR KILQAFPDMH NSNISKILGS RWKAMTNLEK QPYYEEQARL SKQHLEKYPD
YKYKPRPKRT CLVDGKKLRI GEYKAIMRSR RQEMRQYFSV GQQGQLPLSS AGVVYPGALT
MAGMPSPQMP SEHSSMSSSP EPTANHHPNP NLAGLKGDEP RIKEEELRLD DSNGDAYDDF
DYEDEEADYA SDNENHITQ
//
