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Database: UniProt
Entry: H2LZM8_ORYLA
LinkDB: H2LZM8_ORYLA
Original site: H2LZM8_ORYLA 
ID   H2LZM8_ORYLA            Unreviewed;       703 AA.
AC   H2LZM8;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   28-MAR-2018, entry version 41.
DE   SubName: Full=Cyclic nucleotide gated channel alpha 2 {ECO:0000313|Ensembl:ENSORLP00000011601};
GN   Name=CNGA2 {ECO:0000313|Ensembl:ENSORLP00000011601};
OS   Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae;
OC   Oryziinae; Oryzias.
OX   NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000011601, ECO:0000313|Proteomes:UP000001038};
RN   [1] {ECO:0000313|Proteomes:UP000001038}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hd-rR {ECO:0000313|Proteomes:UP000001038};
RX   PubMed=17554307; DOI=10.1038/nature05846;
RA   Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B.,
RA   Yamada T., Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D.,
RA   Shimada A., Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A.,
RA   Asakawa S., Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K.,
RA   Sugano S., Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F.,
RA   Nomoto H., Nogata K., Morishita T., Endo T., Shin-I T., Takeda H.,
RA   Morishita S., Kohara Y.;
RT   "The medaka draft genome and insights into vertebrate genome
RT   evolution.";
RL   Nature 447:714-719(2007).
RN   [2] {ECO:0000313|Ensembl:ENSORLP00000011601}
RP   IDENTIFICATION.
RC   STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000011601};
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
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DR   EMBL; BAAF04035291; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 8090.ENSORLP00000011601; -.
DR   Ensembl; ENSORLT00000011602; ENSORLP00000011601; ENSORLG00000009251.
DR   eggNOG; KOG0500; Eukaryota.
DR   eggNOG; ENOG410YWWI; LUCA.
DR   GeneTree; ENSGT00900000140801; -.
DR   InParanoid; H2LZM8; -.
DR   OMA; TIGEMPP; -.
DR   OrthoDB; EOG091G03EW; -.
DR   TreeFam; TF319048; -.
DR   Proteomes; UP000001038; Chromosome 14.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005216; F:ion channel activity; IEA:InterPro.
DR   CDD; cd00038; CAP_ED; 1.
DR   Gene3D; 2.60.120.10; -; 1.
DR   InterPro; IPR032406; CLZ_dom.
DR   InterPro; IPR018490; cNMP-bd-like.
DR   InterPro; IPR018488; cNMP-bd_CS.
DR   InterPro; IPR000595; cNMP-bd_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   Pfam; PF16526; CLZ; 1.
DR   Pfam; PF00027; cNMP_binding; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   SMART; SM00100; cNMP; 1.
DR   SUPFAM; SSF51206; SSF51206; 1.
DR   PROSITE; PS00888; CNMP_BINDING_1; 1.
DR   PROSITE; PS00889; CNMP_BINDING_2; 1.
DR   PROSITE; PS50042; CNMP_BINDING_3; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001038};
KW   Ion channel {ECO:0000256|SAAS:SAAS00084808};
KW   Ion transport {ECO:0000256|SAAS:SAAS00502700};
KW   Membrane {ECO:0000256|SAAS:SAAS00502630, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00137614,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00137754,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00502637}.
FT   TRANSMEM    187    207       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    219    239       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    319    343       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    397    419       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      501    607       Cyclic nucleotide-binding.
FT                                {ECO:0000259|PROSITE:PS50042}.
FT   COILED      642    694       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   703 AA;  81315 MW;  E14F023F3022C4CE CRC64;
     HNLSVKTTLE EEIERSESIL SRVPSVWDDT TSELQRVAAL DPNDSRNSFQ RTGAISRLVN
     LVVRLREWAH RSLLEEEERP DSFLERFRGP ELKTAPSRNS NTQPDVNGNN AKGIFRYSWQ
     QPLNCFQAAV SVQHHPRISL KSCHAQYFSN GKKFFLCFCV HRFDTFSSTA FRKRWAFFVV
     SPSDDIYYRW LLVISITVLY NWFVVVARAC FDELQVTFFI WWLVLDYISD TVYILDTIVR
     LRTGFLEQGL LVKDHIKLRD SYVRTLQFKL DVASILPTDL GYIATGIHTP QLRFNRLLHF
     PRMFEFFDRT ETRTNYPNIF RICNLVLYIL VIIHWNACIY YAISKSLGFG SDTWVFPNAS
     RTGFTTLSES YVYCLYWSTL TLTTIGEMPP PVRDEEYLFV VFDFLVGVLI FATIVGNVGS
     MISNMNATRA EFQARIDAIK HYMHFRKVSR ELETRVIKWF DYLWTNKKAV DEQEVLKNLP
     NKLRAEIAIN VHLETLKKVR IFKDCEAGLL VELVLKLRQQ VFSPGDYICR KGDIGKEMYI
     IKEGKLAVVA DDGVTQYALL TSGSCFGEIS ILNIKGSKMG NRRTANIRSL GYSDLFCLSK
     DDLMEAVIEY PDAKTVLEER GREILKKEGL LDENADSGGL QKEDTEEKVE RLEMSLDTLQ
     TRFARLLNDY THTQQRLKQR VTLLEQQIND YSAETNTDAD PGP
//
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