ID H2M1F4_ORYLA Unreviewed; 1481 AA.
AC H2M1F4;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=IQ motif containing GTPase activating protein 2 {ECO:0000313|Ensembl:ENSORLP00000012237.2};
GN Name=iqgap2 {ECO:0000313|Ensembl:ENSORLP00000012237.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000012237.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000012237.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000012237.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000012237.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000012237.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR Ensembl; ENSORLT00000012238.2; ENSORLP00000012237.2; ENSORLG00000009749.3.
DR GeneTree; ENSGT00950000183076; -.
DR HOGENOM; CLU_000972_2_1_1; -.
DR Proteomes; UP000001038; Chromosome 9.
DR Bgee; ENSORLG00000009749; Expressed in animal zygote and 14 other cell types or tissues.
DR GO; GO:0120025; C:plasma membrane bounded cell projection; IEA:UniProt.
DR CDD; cd00201; WW; 1.
DR Gene3D; 1.20.5.190; -; 1.
DR Gene3D; 2.20.70.10; -; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR000593; RasGAP_C.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR PANTHER; PTHR14149; RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF; 1.
DR PANTHER; PTHR14149:SF12; RAS GTPASE-ACTIVATING-LIKE PROTEIN IQGAP2; 1.
DR Pfam; PF00307; CH; 1.
DR Pfam; PF00612; IQ; 3.
DR Pfam; PF00616; RasGAP; 1.
DR Pfam; PF03836; RasGAP_C; 1.
DR SMART; SM00033; CH; 1.
DR SMART; SM00015; IQ; 4.
DR SMART; SM00323; RasGAP; 1.
DR SMART; SM00456; WW; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF143885; RGC domain-like; 1.
DR SUPFAM; SSF51045; WW domain; 1.
DR PROSITE; PS50021; CH; 1.
DR PROSITE; PS50096; IQ; 4.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
DR PROSITE; PS01159; WW_DOMAIN_1; 1.
DR PROSITE; PS50020; WW_DOMAIN_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038}.
FT DOMAIN 41..156
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 527..554
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 823..1056
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT COILED 165..192
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1481 AA; 170147 MW; 85ED7DD876390288 CRC64;
MYHEETTGLQ KPRYGTIQDD ERLSAEEMDE RRRQNIAYEY LCHLEEAKRW MEACLDEEMP
PTTELEERLR NGVHLAKLAN FFAPKMVSEK RIYDRDQCRY KNKGLHFRHT DNTVQWLRAM
ELVGLPKIFY PETTDVYDRK NMPKVVYCIH ALSLYLYKLG IAPQIQDLLG KVAFTEEEIS
NMRSELEKYG IQMPSFSKIG GILANELSVD EAALHAAVIA VNEAIDKGQA SVTLAALKNP
NAMLRNIQDA ISHDYQVALS RAKARKQHQS LGRVRPSVAK EERDVYEEFL TQQEIQSCLD
SVNELEAVGR INKAIRLGFA AQTVEELMNP EAQLPIVYQT AANLYQTELF SLQLQGGRSG
LSHEELNVAV EMLSAVAVLN EVLDTKDPQA VVEQLTDSPL GFTNIDHDNL NRYADMLIRE
RADALAKDQE FLSWNDIQKC IDTVNIQVQE EHERIIAIAE INEALSSGDH QQTLAALLLP
TAKLSGVNPE TAKHYHDILQ NTKQLLCQVR WYLCFLFSFP GSSDVLWVKH CIKDKYDFYY
NLQTRQGTWE KPEEYKDSWS QLSKEDIQNV VNCVTAEYNR EQLWLANESL VTRLQARIRG
YLVRKKHSQR MEYLHLQEPY VVKLQACWKG YKQRKVYKER MNLLQKNVDS VIKIQSLAKM
WRAKHKYNQR LKFFKDHEKE IVKIQAFLKA NKARDDYKTL TGAKDPPLSV VRKFVHLLEQ
SPRDLQEEQE MTGLREEVVT KIQKMVHIDV VSHSKKMKNK KSKTSKEDLT GGEKLGIKGL
SKGKRRKLEA YQHLFYLLQT NPSYLAKLIF QMPQNKSTKF MDTVIFTLYN YASNQREEYL
LLKLFRTALA EEINSKVDQI QEIVTGNPTV IKMVVSFNRG ARGHNALRQL LSPVVKDIID
DNSLGINTNP VDVYKAWVNQ VESATGEASK LPYEVTPEQA MSYAEVRNRL QASSEALRSA
TDKVLNSIVC SLDNIPYAMR YIAKVLKNSL HEKFPEASED DVLKIVGNLL YYRYMNPAIV
APDGFDIIDL SAGGQLHQDQ RRNLGSVAKM LQHAAANKLF EGENAHMTPM NKYISQTYEK
LFFQAACDVP EPEEKFNIDE YSDMVTLSKP IIYISIEEII NTHSLLLEHL DAISPDRNDL
LHELLQDLGD VPDVEALLGE GAVDSNDPNR ENALSQLAKT EISLHLTSKF ELLEGDDKDL
KTLMTKTKKL IVDVIRIQPG EALTEILETP ASPPQELEHT KMLERRAAQD AQTPEGLKSS
PAVLEDGQLP LEQKKRKILR NLRNLEQAGL ATASNNYQDL INDIAKDIRY QRRYRQRRKT
ELTKLQQTLT ALNSKTVFYQ EQMNYYDTYI KTCLDNLNRK NSRRSIKLDS KSEDRGSKKW
KPQSLKYTAA RLHEKGVVLE IEGLQTNQFK NVMFDISPTE EVGDFEVKAK FMGVEMEKVQ
LHFQDLLQLQ YDGVAVMKMF DKAKVNVNLL IFLLNRKFYG K
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