ID H2M394_ORYLA Unreviewed; 412 AA.
AC H2M394;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Carbonic anhydrase XIV {ECO:0000313|Ensembl:ENSORLP00000012896.2};
GN Name=ca14 {ECO:0000313|Ensembl:ENSORLP00000012896.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000012896.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000012896.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000012896.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000012896.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000012896.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the alpha-carbonic anhydrase family.
CC {ECO:0000256|ARBA:ARBA00010718}.
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DR RefSeq; XP_011483624.1; XM_011485322.1.
DR AlphaFoldDB; H2M394; -.
DR Ensembl; ENSORLT00000012897.2; ENSORLP00000012896.2; ENSORLG00000010291.2.
DR GeneTree; ENSGT00940000156893; -.
DR HOGENOM; CLU_039326_1_2_1; -.
DR Proteomes; UP000001038; Chromosome 16.
DR Bgee; ENSORLG00000010291; Expressed in brain and 3 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004089; F:carbonate dehydratase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR Gene3D; 3.10.200.10; Alpha carbonic anhydrase; 1.
DR InterPro; IPR001148; CA_dom.
DR InterPro; IPR036398; CA_dom_sf.
DR InterPro; IPR023561; Carbonic_anhydrase_a-class.
DR PANTHER; PTHR18952; CARBONIC ANHYDRASE; 1.
DR PANTHER; PTHR18952:SF84; CARBONIC ANHYDRASE 14; 1.
DR Pfam; PF00194; Carb_anhydrase; 1.
DR SMART; SM01057; Carb_anhydrase; 1.
DR SUPFAM; SSF51069; Carbonic anhydrase; 1.
DR PROSITE; PS51144; ALPHA_CA_2; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 350..372
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 76..337
FT /note="Alpha-carbonic anhydrase"
FT /evidence="ECO:0000259|PROSITE:PS51144"
FT REGION 381..412
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 412 AA; 45883 MW; 620BE0125CFF7686 CRC64;
MFEEIRFFHR GLAGGIAGPS PSLPRLSLTE LVLIPQSLFT HLCVWVQRAN MDSPGLFVLL
CLVIFGQAAA SSAEEITWSY TGLIGQSEWS EYFPDCGGTS QSPVDVITTQ TRFDPSLTPV
RPLGYSQHGN QPFTLYNNGH TAIIVMPEWM GLEGLPWFFT AVQLHLHWGN GGPNQRGSEH
TMNGISADAE LHVVHYNSEL YPNMSAAMTQ KDGLAVLGIL IVTGEETNPA FNKILNYLSR
IKHFGQKVFI PAFDIQSLLP EDLGRYYRYN GSLTTPPCYQ SVMWTVFHER VQISKAQLLK
LETILYSSKA EDPEKMLLQD NYRSTQALNQ RVIYTSFSAE SGKELSSGEV TAIVIGVMCG
CVGLAVIVRF IVKTIRINDP EKEKQKKQDL VLNSTSEAER RDEPSPSCKT EP
//