ID H2M3E0_ORYLA Unreviewed; 692 AA.
AC H2M3E0;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=U4/U6 small nuclear ribonucleoprotein Prp3 {ECO:0000256|ARBA:ARBA00016514};
DE AltName: Full=Pre-mRNA-splicing factor 3 {ECO:0000256|ARBA:ARBA00032955};
GN Name=prpf3 {ECO:0000313|Ensembl:ENSORLP00000012942.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000012942.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000012942.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000012942.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000012942.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000012942.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Plays a role in pre-mRNA splicing as component of the U4/U6-
CC U5 tri-snRNP complex that is involved in spliceosome assembly, and as
CC component of the precatalytic spliceosome (spliceosome B complex).
CC {ECO:0000256|ARBA:ARBA00035603}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR RefSeq; XP_011483626.1; XM_011485324.1.
DR RefSeq; XP_011483627.1; XM_011485325.1.
DR AlphaFoldDB; H2M3E0; -.
DR STRING; 8090.ENSORLP00000012942; -.
DR Ensembl; ENSORLT00000012943.2; ENSORLP00000012942.2; ENSORLG00000010330.2.
DR GeneID; 101159943; -.
DR KEGG; ola:101159943; -.
DR CTD; 9129; -.
DR eggNOG; KOG2769; Eukaryota.
DR GeneTree; ENSGT00390000011497; -.
DR HOGENOM; CLU_015750_3_0_1; -.
DR InParanoid; H2M3E0; -.
DR OrthoDB; 5489218at2759; -.
DR TreeFam; TF313082; -.
DR Proteomes; UP000001038; Chromosome 16.
DR Bgee; ENSORLG00000010330; Expressed in blastula and 14 other cell types or tissues.
DR GO; GO:0046540; C:U4/U6 x U5 tri-snRNP complex; IBA:GO_Central.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR Gene3D; 1.20.1390.10; PWI domain; 1.
DR InterPro; IPR013881; Pre-mRNA_splic_Prp3_dom.
DR InterPro; IPR027104; Prp3.
DR InterPro; IPR010541; Prp3_C.
DR InterPro; IPR002483; PWI_dom.
DR PANTHER; PTHR14212; U4/U6-ASSOCIATED RNA SPLICING FACTOR-RELATED; 1.
DR PANTHER; PTHR14212:SF0; U4_U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP3; 1.
DR Pfam; PF08572; PRP3; 1.
DR Pfam; PF06544; Prp3_C; 1.
DR Pfam; PF01480; PWI; 1.
DR SMART; SM00311; PWI; 1.
DR PROSITE; PS51025; PWI; 1.
PE 4: Predicted;
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW mRNA splicing {ECO:0000256|ARBA:ARBA00023187};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038}.
FT DOMAIN 1..87
FT /note="PWI"
FT /evidence="ECO:0000259|PROSITE:PS51025"
FT REGION 70..141
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 521..546
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 70..127
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 692 AA; 78134 MW; B16C47B64648E800 CRC64;
MSLPKREVEE LRPWVERTVK KVLGFSEPTV VTAALHCVGK GLDKRKTTDQ LRPFLEDSAG
GFVERLFEAL EESRSSRGSK GSGEKNRKRE LKDVFGEEHD SGAKRETSET ADGTVVKRKR
TPRFQEVEEP EVIPGPPSES PGMLTKLQIK QMMEAATKQI EERKKQLSFS SVPSAASQLD
GSRLLGAAGA SSVAPSQAAS FMNDAIEKAR KAAELQARIQ SQLSVKPGIL GALGNTGPHN
LVALANLHAM GIAPPKVEIK EVNKPTPLIL DEKGRTVDAT GKEVELTHRM PTLKANIRAV
KREQFRQQLK EKPSDDLEST SYFDNRVLIT PAQRLRRGFK FHEPGRFEKI AQRVRTKAQL
ERLQNEISQA AKKTGIQAST KLALIAPRKE IGDGEVPSIE WWDSFILPSN IVFKPETRFD
NVEFFGVTNL VEHPTQMRPP VDTDKPVTLG VYLTKKEQKK LRRQTRREAQ KELQEKVRLG
LMPPPEPKVR ISNLMRVLGT EAVQDPTKVE AHVRAQMAKR QKAHEEANAA RKLSTEQRKE
KKVKKLKEDL TNGVHISVYR IRNLTNPAKK FKVEANANQL YLTGTVVLHR DVNLVVVEGG
PKSQKKFRKL MLHRIKWEEH SSKRDDPDVD DTKRNNKCWL IWEGTGKDRS YGEIKFKQCP
TESMAREHFK KHGTEHYWDL ALSHSVLDGT DD
//
