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Database: UniProt
Entry: H2M4T6_ORYLA
LinkDB: H2M4T6_ORYLA
Original site: H2M4T6_ORYLA 
ID   H2M4T6_ORYLA            Unreviewed;      1651 AA.
AC   H2M4T6;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   25-OCT-2017, entry version 38.
DE   RecName: Full=Voltage-dependent L-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   Name=LOC101160313 {ECO:0000313|Ensembl:ENSORLP00000013457};
OS   Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae;
OC   Oryziinae; Oryzias.
OX   NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000013457, ECO:0000313|Proteomes:UP000001038};
RN   [1] {ECO:0000313|Proteomes:UP000001038}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hd-rR {ECO:0000313|Proteomes:UP000001038};
RX   PubMed=17554307; DOI=10.1038/nature05846;
RA   Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B.,
RA   Yamada T., Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D.,
RA   Shimada A., Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A.,
RA   Asakawa S., Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K.,
RA   Sugano S., Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F.,
RA   Nomoto H., Nogata K., Morishita T., Endo T., Shin-I T., Takeda H.,
RA   Morishita S., Kohara Y.;
RT   "The medaka draft genome and insights into vertebrate genome
RT   evolution.";
RL   Nature 447:714-719(2007).
RN   [2] {ECO:0000313|Ensembl:ENSORLP00000013457}
RP   IDENTIFICATION.
RC   STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000013457};
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. The isoform alpha-1C
CC       gives rise to L-type calcium currents. Long-lasting (L-type)
CC       calcium channels belong to the 'high-voltage activated' (HVA)
CC       group. They are blocked by dihydropyridines (DHP),
CC       phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA
CC       (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-
CC       GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA).
CC       Calcium channels containing the alpha-1C subunit play an important
CC       role in excitation-contraction coupling in the heart. Binding of
CC       calmodulin or CABP1 at the same regulatory sites results in an
CC       opposit effects on the channel function.
CC       {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSORLP00000013457}.
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DR   EMBL; BAAF04056458; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BAAF04056459; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BAAF04056460; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BAAF04056461; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BAAF04056462; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BAAF04056463; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BAAF04056464; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BAAF04114096; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BAAF04114097; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BAAF04114098; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 8090.ENSORLP00000013457; -.
DR   Ensembl; ENSORLT00000013458; ENSORLP00000013457; ENSORLG00000010732.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128247; -.
DR   OMA; ACSYGKL; -.
DR   OrthoDB; EOG091G0TKO; -.
DR   TreeFam; TF312805; -.
DR   Proteomes; UP000001038; Chromosome 5.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR005450; VDCC_L_a1ssu.
DR   InterPro; IPR005446; VDCC_L_a1su.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   PANTHER; PTHR10037:SF190; PTHR10037:SF190; 1.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01630; LVDCCALPHA1.
DR   PRINTS; PR01634; LVDCCALPHA1S.
DR   SMART; SM01062; Ca_chan_IQ; 1.
DR   PROSITE; PS50222; EF_HAND_2; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001038};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM     63     80       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    100    120       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    132    150       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    204    226       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    319    341       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    441    459       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    480    502       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    514    537       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    569    591       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    649    671       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    808    831       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    843    862       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    929    958       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1052   1081       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1124   1144       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1165   1183       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1278   1301       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1369   1393       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1409   1444       EF-hand. {ECO:0000259|PROSITE:PS50222}.
SQ   SEQUENCE   1651 AA;  188126 MW;  38212E3B272E692D CRC64;
     SNPPLSSYIM DEETLKRKQK EKLKKLMATG GNPRPARSLL FFTLRNPFRR ACISIVEWKP
     FEIIILLSIF ANCVALAVYL PMPEEDSNNT NSNLESLEYI FLIIFSIECF LKIIAYGFLF
     HADAYLRNCW NILDFVCVSV GLFTVAMDAI NHISGVEAPV GEKGGGFDMK ALRAFRVLRP
     LRLVSGVPSL QVVMNSILKS MLPLFHITLL VFFMVTIYSI MGLELFKCKM HKTCYYVGTD
     IIASVDNEKP APCAQAGNGR KCLINGTECR AGWPGPNNGI THFDNLGFSM LTVYQCITTQ
     GWTDVLYWVN DAIGMEWPWI FFTTLILVGS FFVLNLVLGV LSGEFTKERE KAKSRGEFQK
     LRETQQLDED LKGYMDWITQ AEVIDNDNDR QGLLPLENGN SEAGSVGQMD TMQLIIFYYK
     LARKWNRWLR RKCRVYVKSK LFHWWVIILV LLNTLAIATE HHKQSQRLTN WQDQETTNKL
     LLSMFALEMF MKMYALGLPP YFMSLFNRFD CFVVSIGILE LILVHMGVMS VMGISVLRCI
     RLLRLLKVTR YWTSLSNLVA SLLNSVRSIA CLLLLLFLFI VIFSLLGMQV FGGKFNFPNQ
     PQPRSTFDSF PQALITVFQI LTGEDWNTVM YDGILAHGGP TMPGILVSLY FIILFVCGNF
     ILLNVFLAIA VDNLAEAESL TLAQKEKAEE KKRKKALRPN ISDKATEEKA LLAKKLAEQR
     AKGVEGIPTT AKLKIDEFES NVNEIKDPFP PADFPGDDEE EDPAIPESPR PRPMADLQLK
     EEAVPMPEAS SFFIFGPQNK FRKLCHRIIN ATTFTNIILL FILLSSISLA AEDPIDPVSP
     RNQVLAYADI VFTSVFTAEI VLKMTTYGAI LHKGSFCRNS FNILDLLVVS VSLLSMGMES
     SAISVVKILR VLRVLRPLRA INRAKGLKHV VQCVFVAVKT IGNIVLVTML LDFMFACIGV
     QLFRGKFYSC TDPDQMTEET CKGWYIRYQE GALHEMEVRK REWTNAQLNF DNIFNGMLSL
     FTISTFEGWP KILYKAIDSN MEDKGPIYNN RVAISIFFII YLILIAFFMM NIFVGFVIVT
     FQEQGEQEYK DCELDKNQRQ CVQYALKARP LRCYIPKNPY QYQVWYIVTS CYFEYLMFLL
     IMLNTMCLGM QHCNQSDHVT HLSDMLNVIF TVLFTVEMIL KLMAFKAKGY FGDPWNVFDF
     VIVIGSVVDV MLSEIDGALA SSGGLYCLHG CSSEKASENM SVSITFFRLF RVMRLVKLLN
     RSEGIRNLLW TFIKSLQALP YVALLILMLF FIYAVVGMQV FGKIALMDGT FINRNNNFQT
     FPQAVLLLFR CATGEAWHEV MLACMYGKKC DPKSDFLPGE ENTCGSNFAI IYFMSFYMLC
     AFLIINLFVA VIMDNFDYLT RDWSILGPQH LDEFKKIWAE YDPEATGRIK HLDVVTLLRR
     IPPPLGFGKF CPHRIACKRL VSMNMPLNSD GTVTFNATLF ALVRTALKIK TEGNFEQANE
     ELRGIIKKIW KRTSMKLLDQ VIPPIGDDEV TVGKFYATFL IQDYYRKLKK RQEEYYGYHP
     TKKSATHEIQ AGLRNIAEEA PAELHRSISG DLLAEEDSDH GVEEIFRRQA SLFGNHSDPF
     AVETDPAYTS QRPLQMDEGF TNNISMSQSQ F
//
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