ID H2M4W8_ORYLA Unreviewed; 376 AA.
AC H2M4W8;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 72.
DE RecName: Full=CCN family member 1 {ECO:0000256|ARBA:ARBA00039941};
DE AltName: Full=Cellular communication network factor 1 {ECO:0000256|ARBA:ARBA00042351};
DE AltName: Full=Protein CYR61 {ECO:0000256|ARBA:ARBA00042204};
GN Name=ccn1 {ECO:0000313|Ensembl:ENSORLP00000013490.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000013490.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000013490.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000013490.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000013490.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000013490.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the CCN family. {ECO:0000256|ARBA:ARBA00008125}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00039}.
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DR RefSeq; XP_004068081.1; XM_004068033.2.
DR AlphaFoldDB; H2M4W8; -.
DR STRING; 8090.ENSORLP00000013490; -.
DR Ensembl; ENSORLT00000013491.2; ENSORLP00000013490.2; ENSORLG00000010756.2.
DR GeneID; 101157527; -.
DR KEGG; ola:101157527; -.
DR CTD; 3491; -.
DR eggNOG; ENOG502QQQQ; Eukaryota.
DR GeneTree; ENSGT00940000155151; -.
DR InParanoid; H2M4W8; -.
DR OrthoDB; 2970572at2759; -.
DR TreeFam; TF326070; -.
DR Proteomes; UP000001038; Chromosome 4.
DR Bgee; ENSORLG00000010756; Expressed in bone element and 14 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0019838; F:growth factor binding; IEA:UniProtKB-KW.
DR GO; GO:0031101; P:fin regeneration; IEA:Ensembl.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 1.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 1.
DR InterPro; IPR006207; Cys_knot_C.
DR InterPro; IPR006208; Glyco_hormone_CN.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR000867; IGFBP-like.
DR InterPro; IPR012395; IGFBP_CNN.
DR InterPro; IPR043973; TSP1_CCN.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR InterPro; IPR001007; VWF_dom.
DR PANTHER; PTHR11348:SF18; CCN FAMILY MEMBER 1; 1.
DR PANTHER; PTHR11348; CONNECTIVE TISSUE GROWTH FACTOR-RELATED; 1.
DR Pfam; PF00007; Cys_knot; 1.
DR Pfam; PF00219; IGFBP; 1.
DR Pfam; PF19035; TSP1_CCN; 1.
DR Pfam; PF00093; VWC; 1.
DR PIRSF; PIRSF036495; IGFBP_rP_CNN; 1.
DR SMART; SM00041; CT; 1.
DR SMART; SM00121; IB; 1.
DR SMART; SM00209; TSP1; 1.
DR SMART; SM00214; VWC; 1.
DR SUPFAM; SSF57603; FnI-like domain; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 1.
DR PROSITE; PS01185; CTCK_1; 1.
DR PROSITE; PS01225; CTCK_2; 1.
DR PROSITE; PS51323; IGFBP_N_2; 1.
DR PROSITE; PS50092; TSP1; 1.
DR PROSITE; PS01208; VWFC_1; 1.
DR PROSITE; PS50184; VWFC_2; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Growth factor binding {ECO:0000256|ARBA:ARBA00023183};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..376
FT /note="CCN family member 1"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017352589"
FT DOMAIN 21..95
FT /note="IGFBP N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51323"
FT DOMAIN 99..165
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 281..355
FT /note="CTCK"
FT /evidence="ECO:0000259|PROSITE:PS01225"
SQ SEQUENCE 376 AA; 41889 MW; 1B4C71F37C2FE6DD CRC64;
MLMLHSLVFF IGSLTLVLSY PPSSCPSVCE CQVEMPKCAP GVSVVLDGCN CCRVCARQLN
EDCSLTEPCD HTKGLECNFG ASLAAATTRG ICRAKSEGRP CEYNSRIYQN GESFQPNCKH
QCTCIDGAVG CVPLCPQELS LPNLGCANPR LVKVAGQCCE EWVCEDGKET DILEKIFGKD
KLTEELEKDL TNRNELIAIV KGGLKTLPAY RPQPEVYMFD SPKCIVQTTP WSQCSKSCGT
GISTRVTNNN NECKLVRETR LCEVRPCTQS SYASLKKGKK CNRTKKSSQP VKFTYAGCSS
VKKYRPRYCG SCVDGRCCSP HDTRTIQVKF RCEDGETFYK KTMMIETCKC THNCPHVNEA
SYPFYRLSND IHKFRD
//
