ID H2M550_ORYLA Unreviewed; 1272 AA.
AC H2M550;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 24-JAN-2024, entry version 59.
DE SubName: Full=RIMS-binding protein 2 {ECO:0000313|Ensembl:ENSORLP00000013572.2};
GN Name=LOC101174933 {ECO:0000313|Ensembl:ENSORLP00000013572.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000013572.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000013572.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000013572.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000013572.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000013572.2};
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the RIMBP family.
CC {ECO:0000256|ARBA:ARBA00010749}.
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DR AlphaFoldDB; H2M550; -.
DR Ensembl; ENSORLT00000013573.2; ENSORLP00000013572.2; ENSORLG00000010821.2.
DR eggNOG; KOG3632; Eukaryota.
DR GeneTree; ENSGT00950000183203; -.
DR HOGENOM; CLU_001979_0_0_1; -.
DR TreeFam; TF316230; -.
DR Proteomes; UP000001038; Chromosome 12.
DR Bgee; ENSORLG00000010821; Expressed in brain and 5 other cell types or tissues.
DR CDD; cd00063; FN3; 2.
DR CDD; cd12014; SH3_RIM-BP_1; 1.
DR CDD; cd12012; SH3_RIM-BP_2; 1.
DR CDD; cd12013; SH3_RIM-BP_3; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 2.30.30.40; SH3 Domains; 3.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR035753; RIM-BP_SH3_2.
DR InterPro; IPR035755; RIM-BP_SH3_3.
DR InterPro; IPR040325; RIMBP1/2/3.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR14234; RIM BINDING PROTEIN-RELATED; 1.
DR PANTHER; PTHR14234:SF18; RIMS-BINDING PROTEIN 2; 1.
DR Pfam; PF07653; SH3_2; 2.
DR Pfam; PF14604; SH3_9; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00060; FN3; 3.
DR SMART; SM00326; SH3; 3.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR SUPFAM; SSF50044; SH3-domain; 3.
DR PROSITE; PS50002; SH3; 3.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 166..233
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 992..1060
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 1095..1162
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 98..166
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 598..768
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 784..923
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 968..987
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1169..1272
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 98..153
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 598..700
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 749..763
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 791..835
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 845..865
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 899..913
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1170..1193
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1238..1255
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1256..1272
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1272 AA; 141852 MW; 6956512BB2CD946B CRC64;
MHEAVELKQQ LQTEYEQTFV ALHTKQKEIN RLQKAWVQTD QEHEEALHLL KVKVRDLEQV
CRSFSENLNQ LPNELLDYYL QSAPVEIKSD LSWKNQIQST QRETLPPTTA GFEAQSKKGQ
TQPPELRSIK SSPVATERPN SSSQFSPSEM EDEASPSPRS KPRYTGQVRL CTARYSYNPY
DGPNEHPEAE LPLVAGKYLY VYGEMDDDGF YEGELLDGQR GLVPSNFVEF VQDKEKPTGE
GGNDLGPLEH TSLALVPVDG GTSQDGLLGS NNALVPYSNG TGGTLDPEDL AEDVVPYPRK
INLIKQLARS VIVAWEPPVV PLGWGNITGY NVLVDGEIRA SMPYGSRTKC LLEKLDLDAC
VYRVSVQSAT DRGLSDELRC TLLVGANVVV APYGLRVDDI QQDTAELSWL PSNSNYAHTV
FLDGVEHAVV KSGRYRLRFH NLKPLTVYKV TVVAQPHQMP WQLPLEQRER KEAGVEFCTQ
AAGPTPFFIQ GPPLPPHDVQ VLCGQGQGVL QVRWKPPMLS STGTSNGANV IGYAVCTKGQ
RIAEVLFPMA DYVTVELSRI QCLEAREVIV RTLSLQGESQ DSHVAVIPNN LLVPLPPIAL
PPPMHPRAGP PPQPHPQAHL QSPHLPHPTP QHPALPHPQP LPPNAPNPQT HPRLPHPCGP
SQPQLHPHPQ PQHPQPPHPG PRPHHLLPLL PHPHPHPVPQ RPISARDLNA KEHTVHHGGA
LPPGQPGWDP MRSPSQPPVP MQGHTLEAPP QANLRSPSPQ RILPQPRGTL IPDTVAKAIA
REAAQRVAAE GGKGTRKHER YGDQGHSFHQ HHSDEEEEDE EGFSRGRRRG PSVDEFLRGS
ELGRPLHYSH NEEYHSESSR GSDLSDIMEE DEEELYSEMQ LEEGRRRNSH NTPKSNTSGG
GHHDREGGRQ MHHGGPHPQR RPLMVPSIEV TTENNSERNH SPTIEDVNCG RVARHRKWAS
RRHTGCIRPR HDGYRDRDRR SPTYYEESEP EEPFRIFVAL FDYDPLSMSP NPDAADEELP
FKEGQIIRVY GDKDTDGFYR GEIRGRMGLI PCNMVSEIRA DDDETMEELI KQGFLPLCTP
VDRIEQNRRG LRRDQASRRM VALYDYDPRE SSPNVDVEAE LTFCAGDIIA VFGDIDEDGF
YYGELNGHRG LVPSNFLEEV PDDVEVYLTD TPSQHPQEGP TNRSNTNSAT TVPEGKRAAP
ETNDTANNIS IPVRAPSPII RPLLPGTMRP LSPSRSSHIP RDPRDSQDLA NKKKKGLLSK
GKKLLKRLSP VK
//