ID H2M6S4_ORYLA Unreviewed; 1354 AA.
AC H2M6S4;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=Early endosome antigen 1 {ECO:0000313|Ensembl:ENSORLP00000014172.2};
GN Name=EEA1 {ECO:0000313|Ensembl:ENSORLP00000014172.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000014172.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000014172.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000014172.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000014172.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000014172.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR STRING; 8090.ENSORLP00000014172; -.
DR Ensembl; ENSORLT00000014173.2; ENSORLP00000014172.2; ENSORLG00000011313.2.
DR eggNOG; ENOG502QWB5; Eukaryota.
DR GeneTree; ENSGT00940000156910; -.
DR HOGENOM; CLU_256550_0_0_1; -.
DR InParanoid; H2M6S4; -.
DR TreeFam; TF329698; -.
DR Proteomes; UP000001038; Chromosome 6.
DR Bgee; ENSORLG00000011313; Expressed in intestine and 14 other cell types or tissues.
DR GO; GO:0005769; C:early endosome; IBA:GO_Central.
DR GO; GO:0005545; F:1-phosphatidylinositol binding; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006897; P:endocytosis; IBA:GO_Central.
DR CDD; cd15730; FYVE_EEA1; 1.
DR Gene3D; 1.10.287.1490; -; 2.
DR Gene3D; 1.20.5.390; L1 transposable element, trimerization domain; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR23164; EARLY ENDOSOME ANTIGEN 1; 1.
DR PANTHER; PTHR23164:SF17; EARLY ENDOSOME ANTIGEN 1; 1.
DR Pfam; PF01363; FYVE; 1.
DR SMART; SM00064; FYVE; 1.
DR SUPFAM; SSF69979; Eea1 homodimerisation domain; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT DOMAIN 1295..1353
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT REGION 528..559
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 714..735
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 803..905
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 917..936
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 946..982
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1179..1283
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 807..870
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 884..905
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1354 AA; 155344 MW; 93EF26068111DD51 CRC64;
MKSHNSAEEL FKHYELFHDT GELPAHVAPT REDLTMLRQE VQDLHASLKE ERWFSGELKK
ELDKVQGHLK QNDGQTSSDD SVLERKLNEA ETEKFNIKQM KDLFEQKAAQ LATEIVDLKS
RYDEERSLRE AAEQRLARMT VQLQTEQQEN EKLQSELLQR PGVEDVEVLR KELVQVQTLM
DNTTREREEE SERLKNQYEQ LQANYTTSEV TISQLKAELE KGPQEAAVYT QQIHQLQSNL
NHLQQQCQRL SEKLERKEKE YEDLQEHLGS EKAAKTEVQD RLKERDLEVQ DLQARATGAE
NCLQKAQAEL KERAEEVTKF KSEVAELEVK NAELKVERKQ LEQQKEEKES QGAQQQTEIN
QLHAKLLETE RQLGEVQGRL KEQRQLSGEK LKDREQQAAD LQLKLSRAEE QLKESTSKNT
DLQHLLEKAK QQHQELQALQ QNTNGKLREA QNDLEQVLRQ IGDKDQKIQN LEALLQKSKD
IVSQLEVERE DLCAKIQAGE GETAVLNQLK EKNHALQEQV TQLTNKLKNQ SESNKQAQDN
LHKQVQEQKS LLRSAQDRAH TLETSVTELT AQLTDSKEKV SQLDAQLKAK TELLLSAEAA
KAAQKANLEN SLETAQHALQ DKQQELNKNQ KKVEEQAQRL KERQEQCTQL ETNLKECRDK
LLASEQRVEQ LEGLNKKLES QVVEVRTARD QAQLELEALQ KEGVEVKQKA KELQRSLETE
KEGSKTLQEE LKKKGASLAD SQQQLQRCEQ DLSALKASLD AVTQEGKTQR AELEKKTQSL
AADLQKVQQE KEAQRKELVT VQENLGKTKK MLKESQSQLE AERKSHQSVM EEKEKSNEKA
RQELLKSNEA VTKAAKESKE QLEQSKGAEK KLKAQLTSLE QQHSKTREAL KDKEDEVGKQ
RELLKTMQKS LEDEVKKLKG QVTQLQEAGV KKAEEETKLR ARLSSLDQEL ASQKSRAAEL
QKALEQSQEK HSQLQSDSFG KESELSALRQ DLKVLEDKLR VAQEELAANR SHQTGMEAQI
QELKAARGSL EQELTKREQK LQQQEHALKE LKKQEDQMKA ELQQERNKVS ELNKDRSALE
KTNATLSSEL KTQTEKIKKE LGELQEAKQL LIQQKLELQG QVEAAQEALK EEQKEHQATR
DGMSKREEQL LTQTKAIQDQ LGAEKRAREE QVRRGEEAEA KLSVQVTALN ENVATLKREW
QGSQRRVSEL EKQTDELRGE IAVLEATVQN NQDERRALLE RCVKGEGEIE RLQAKVVELR
RKLDDTTAAM QELGRENQSL QIKQSQSLTR KWAEDHEVQN CMACGKGFSV TVRKHHCRHC
GNIFCAECSS RNALTPSSKK PVRVCETCFE ELQG
//
