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Database: UniProt
Entry: H2M7V9_ORYLA
LinkDB: H2M7V9_ORYLA
Original site: H2M7V9_ORYLA 
ID   H2M7V9_ORYLA            Unreviewed;      1701 AA.
AC   H2M7V9;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 2.
DT   24-JAN-2024, entry version 80.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=LOC101170963 {ECO:0000313|Ensembl:ENSORLP00000014568.2};
OS   Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC   Oryzias.
OX   NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000014568.2, ECO:0000313|Proteomes:UP000001038};
RN   [1] {ECO:0000313|Ensembl:ENSORLP00000014568.2, ECO:0000313|Proteomes:UP000001038}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000014568.2,
RC   ECO:0000313|Proteomes:UP000001038};
RX   PubMed=17554307; DOI=10.1038/nature05846;
RA   Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA   Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA   Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA   Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA   Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA   Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT   "The medaka draft genome and insights into vertebrate genome evolution.";
RL   Nature 447:714-719(2007).
RN   [2] {ECO:0000313|Ensembl:ENSORLP00000014568.2}
RP   IDENTIFICATION.
RC   STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000014568.2};
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability of
CC       excitable membranes. Assuming opened or closed conformations in
CC       response to the voltage difference across the membrane, the protein
CC       forms a sodium-selective channel through which Na(+) ions may pass in
CC       accordance with their electrochemical gradient.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651,
CC       ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU361132}.
CC       Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|RuleBase:RU361132}.
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DR   Ensembl; ENSORLT00000014569.2; ENSORLP00000014568.2; ENSORLG00000011619.2.
DR   eggNOG; KOG2301; Eukaryota.
DR   GeneTree; ENSGT00940000167352; -.
DR   HOGENOM; CLU_000540_5_0_1; -.
DR   TreeFam; TF323985; -.
DR   Proteomes; UP000001038; Chromosome 19.
DR   Bgee; ENSORLG00000011619; Expressed in muscle tissue and 4 other cell types or tissues.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   CDD; cd13433; Na_channel_gate; 1.
DR   Gene3D; 1.10.287.70; -; 4.
DR   Gene3D; 1.10.238.10; EF-hand; 1.
DR   Gene3D; 1.20.5.1190; iswi atpase; 1.
DR   Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR044564; Na_chnl_inactivation_gate.
DR   InterPro; IPR010526; Na_trans_assoc_dom.
DR   InterPro; IPR043203; VGCC_Ca_Na.
DR   InterPro; IPR027359; Volt_channel_dom_sf.
DR   PANTHER; PTHR10037:SF223; SODIUM CHANNEL PROTEIN TYPE 4 SUBUNIT ALPHA; 1.
DR   PANTHER; PTHR10037; VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 2.
DR   PRINTS; PR00170; NACHANNEL.
DR   SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
DR   PROSITE; PS50222; EF_HAND_2; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Ion channel {ECO:0000256|ARBA:ARBA00023303, ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW   ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Sodium {ECO:0000256|ARBA:ARBA00023053, ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW   ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW   ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW   ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM        93..112
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361132"
FT   TRANSMEM        157..176
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361132"
FT   TRANSMEM        188..209
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361132"
FT   TRANSMEM        215..235
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361132"
FT   TRANSMEM        333..352
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361132"
FT   TRANSMEM        372..399
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361132"
FT   TRANSMEM        502..520
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361132"
FT   TRANSMEM        532..550
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361132"
FT   TRANSMEM        570..591
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361132"
FT   TRANSMEM        612..640
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361132"
FT   TRANSMEM        699..725
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361132"
FT   TRANSMEM        902..920
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361132"
FT   TRANSMEM        941..957
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361132"
FT   TRANSMEM        969..989
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361132"
FT   TRANSMEM        1018..1044
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361132"
FT   TRANSMEM        1143..1166
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361132"
FT   TRANSMEM        1224..1242
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361132"
FT   TRANSMEM        1254..1276
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361132"
FT   TRANSMEM        1288..1304
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361132"
FT   TRANSMEM        1341..1369
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361132"
FT   TRANSMEM        1445..1468
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361132"
FT   DOMAIN          1485..1520
FT                   /note="EF-hand"
FT                   /evidence="ECO:0000259|PROSITE:PS50222"
FT   COILED          396..430
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   1701 AA;  194336 MW;  77A54A9081F8C477 CRC64;
     MATLLPPHGT DFFRPFTRES LVEIERLEAE SKKLVKVEEE NEAAAPHPDL EAGKNLPMIF
     GDPPPELLNT PLEDLDPFYK AQKTFIVISK GNTIYSMFIM ITILSNCVMM TMSNPPAWSK
     TIEYVFTGIY TVEATIKVLS RGFLVGSFTF LRDPWNWLDF MVISMAYITE FVDLGNISAL
     RTFRVLRALK TITVIPGLKT IVAALIQSVK KMVDVMVLTV FALAVFALVG LQLFMGNLRQ
     KCVRWPILTN ETTSEFLNSS STFNHTVDFN NITANNNSVY SNSTFNFMEY IENIENYYYL
     DGSKDALLCG NSSDAGYCPD GFTCMKAGRN PNFGYTSFDS FGWAFLALFR LMTQDYWENL
     FQLILRAAGR TYMLFFVAII FLGSFYLINL ILAVVAMAYE EQNQATQREA IEKEEEFQRL
     LEQLKNQEKV IILNNGETVK DCNGRLVPHL IIRAPTMTEL EEAQRPRPPC WYRFADMFLK
     WNCCMSWVVF KKWVHFVVMD PFVDLAITIC IVLNTLFMAM EHYPMTAEFD HMLSVGNLVF
     TGIFTAEMFF KLIAMDPYYY FQVGWNIFDS IIVTLSLVEL GLANVQGLSV LRSFRLLRVF
     KLAKSWPTLN MLIKIIGNSV GALGNLTLVL AIIVFIFAVV GMQLFGKSYK ECVCKISSDC
     ELPRWHMNDF FHSFLIVFRI LCGEWIETMW DCMEVAGTAM CLIVFMMVMV IGNLVVLNLF
     LALLLSSFSG DNLAPGDEDG EMNNLQIAIS RLTRGTDWLK AFAIRKVLQM IGRKPKKADI
     SCVDDVSSRT EAIEINHFNT CQPLTAAEKT PECTAESRPL TFFLDGNLHL NVPIAEQESD
     FENLSVDDEE DDEEDCDSSD VAEKGNKCVS RWPCLTVDVT KGKGKKWWNL RKTCFTIVEH
     DWFETFIVFM ILLSSGALAF EDVHIERRRT IKTILEFADK VFTYIFVIEM LLKWVAYGFK
     TYFTNAWCWL DFFIVDISLV SLVASWLGYS DLGPIKSLRT LRALRPLRAL SRFEGMRVVV
     NALVGAIPSI FNVMLVCLIF WLIFSIMGVN LFAGKFYRCI NTTTDAIFTL AEVNNHSECD
     ALNEDTQEAR WVNVKINFDN VGKGYLSLLQ VATFKGWMDI MYAAVDSREI EEQPSYEINL
     YMYMYFVIFI IFGSFFTLNL FIGVIIDNFN QQKRKINQDI FMTEDQKRYQ EVMRKLGSKK
     PQKPIPRPTN FLQGMVFDLI SQQFFDIFIM VLICLNMVTM MVETDDQSAE MEDFLFKLNV
     AFIVVFTGEC LLKLFALRHY FFTNGWNVFD FIVVILSIAG TMLSDLIEKY FVSPTLFRVI
     RLARIGRILR LIKGAKGIRT LLFALMMSLP ALFNIGLLLF LIMFIFSIFA MSNFAYVKKE
     AGIDDIFNFE TFGGSIICLF QITTSAGWDG LLLPILNREP PDCDPDFENP GTDVKGNCGN
     PGMGMMFFCS YIIISFLVVV NMYIAIILEN FNVAQEESGD PLCEEDFEMF NETWEKFDLD
     GTMFINYCQL SDFCDALQEP LRVAKPNRLH LIEMDLPLVI GDRLHFVDVL MAVTQMVLGD
     TVEMAAMRES IQVKFAMSNP SKDSFAPITT TVRHKEEHTA AIIIQQAYRK HLLKRCIHRA
     AVLHRLKRMG KQDEGEDPLE KGLLEKQLGI LYGSSQDLAE EVEQVATGGY TLEPEKMVVP
     VEIVKDMLLH SSPNQNRRTS Q
//
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