ID H2M7V9_ORYLA Unreviewed; 1701 AA.
AC H2M7V9;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 24-JAN-2024, entry version 80.
DE RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN Name=LOC101170963 {ECO:0000313|Ensembl:ENSORLP00000014568.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000014568.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000014568.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000014568.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000014568.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000014568.2};
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability of
CC excitable membranes. Assuming opened or closed conformations in
CC response to the voltage difference across the membrane, the protein
CC forms a sodium-selective channel through which Na(+) ions may pass in
CC accordance with their electrochemical gradient.
CC {ECO:0000256|RuleBase:RU361132}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651,
CC ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU361132}.
CC Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC {ECO:0000256|RuleBase:RU361132}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU361132}.
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DR Ensembl; ENSORLT00000014569.2; ENSORLP00000014568.2; ENSORLG00000011619.2.
DR eggNOG; KOG2301; Eukaryota.
DR GeneTree; ENSGT00940000167352; -.
DR HOGENOM; CLU_000540_5_0_1; -.
DR TreeFam; TF323985; -.
DR Proteomes; UP000001038; Chromosome 19.
DR Bgee; ENSORLG00000011619; Expressed in muscle tissue and 4 other cell types or tissues.
DR GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR CDD; cd13433; Na_channel_gate; 1.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.20.5.1190; iswi atpase; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR001696; Na_channel_asu.
DR InterPro; IPR044564; Na_chnl_inactivation_gate.
DR InterPro; IPR010526; Na_trans_assoc_dom.
DR InterPro; IPR043203; VGCC_Ca_Na.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR10037:SF223; SODIUM CHANNEL PROTEIN TYPE 4 SUBUNIT ALPHA; 1.
DR PANTHER; PTHR10037; VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR Pfam; PF06512; Na_trans_assoc; 2.
DR PRINTS; PR00170; NACHANNEL.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
DR PROSITE; PS50222; EF_HAND_2; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303, ECO:0000256|RuleBase:RU361132};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU361132};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361132};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Sodium {ECO:0000256|ARBA:ARBA00023053, ECO:0000256|RuleBase:RU361132};
KW Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW ECO:0000256|RuleBase:RU361132};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW ECO:0000256|RuleBase:RU361132};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361132};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361132};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361132};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW ECO:0000256|RuleBase:RU361132}.
FT TRANSMEM 93..112
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 157..176
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 188..209
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 215..235
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 333..352
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 372..399
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 502..520
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 532..550
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 570..591
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 612..640
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 699..725
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 902..920
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 941..957
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 969..989
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1018..1044
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1143..1166
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1224..1242
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1254..1276
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1288..1304
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1341..1369
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1445..1468
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT DOMAIN 1485..1520
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT COILED 396..430
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1701 AA; 194336 MW; 77A54A9081F8C477 CRC64;
MATLLPPHGT DFFRPFTRES LVEIERLEAE SKKLVKVEEE NEAAAPHPDL EAGKNLPMIF
GDPPPELLNT PLEDLDPFYK AQKTFIVISK GNTIYSMFIM ITILSNCVMM TMSNPPAWSK
TIEYVFTGIY TVEATIKVLS RGFLVGSFTF LRDPWNWLDF MVISMAYITE FVDLGNISAL
RTFRVLRALK TITVIPGLKT IVAALIQSVK KMVDVMVLTV FALAVFALVG LQLFMGNLRQ
KCVRWPILTN ETTSEFLNSS STFNHTVDFN NITANNNSVY SNSTFNFMEY IENIENYYYL
DGSKDALLCG NSSDAGYCPD GFTCMKAGRN PNFGYTSFDS FGWAFLALFR LMTQDYWENL
FQLILRAAGR TYMLFFVAII FLGSFYLINL ILAVVAMAYE EQNQATQREA IEKEEEFQRL
LEQLKNQEKV IILNNGETVK DCNGRLVPHL IIRAPTMTEL EEAQRPRPPC WYRFADMFLK
WNCCMSWVVF KKWVHFVVMD PFVDLAITIC IVLNTLFMAM EHYPMTAEFD HMLSVGNLVF
TGIFTAEMFF KLIAMDPYYY FQVGWNIFDS IIVTLSLVEL GLANVQGLSV LRSFRLLRVF
KLAKSWPTLN MLIKIIGNSV GALGNLTLVL AIIVFIFAVV GMQLFGKSYK ECVCKISSDC
ELPRWHMNDF FHSFLIVFRI LCGEWIETMW DCMEVAGTAM CLIVFMMVMV IGNLVVLNLF
LALLLSSFSG DNLAPGDEDG EMNNLQIAIS RLTRGTDWLK AFAIRKVLQM IGRKPKKADI
SCVDDVSSRT EAIEINHFNT CQPLTAAEKT PECTAESRPL TFFLDGNLHL NVPIAEQESD
FENLSVDDEE DDEEDCDSSD VAEKGNKCVS RWPCLTVDVT KGKGKKWWNL RKTCFTIVEH
DWFETFIVFM ILLSSGALAF EDVHIERRRT IKTILEFADK VFTYIFVIEM LLKWVAYGFK
TYFTNAWCWL DFFIVDISLV SLVASWLGYS DLGPIKSLRT LRALRPLRAL SRFEGMRVVV
NALVGAIPSI FNVMLVCLIF WLIFSIMGVN LFAGKFYRCI NTTTDAIFTL AEVNNHSECD
ALNEDTQEAR WVNVKINFDN VGKGYLSLLQ VATFKGWMDI MYAAVDSREI EEQPSYEINL
YMYMYFVIFI IFGSFFTLNL FIGVIIDNFN QQKRKINQDI FMTEDQKRYQ EVMRKLGSKK
PQKPIPRPTN FLQGMVFDLI SQQFFDIFIM VLICLNMVTM MVETDDQSAE MEDFLFKLNV
AFIVVFTGEC LLKLFALRHY FFTNGWNVFD FIVVILSIAG TMLSDLIEKY FVSPTLFRVI
RLARIGRILR LIKGAKGIRT LLFALMMSLP ALFNIGLLLF LIMFIFSIFA MSNFAYVKKE
AGIDDIFNFE TFGGSIICLF QITTSAGWDG LLLPILNREP PDCDPDFENP GTDVKGNCGN
PGMGMMFFCS YIIISFLVVV NMYIAIILEN FNVAQEESGD PLCEEDFEMF NETWEKFDLD
GTMFINYCQL SDFCDALQEP LRVAKPNRLH LIEMDLPLVI GDRLHFVDVL MAVTQMVLGD
TVEMAAMRES IQVKFAMSNP SKDSFAPITT TVRHKEEHTA AIIIQQAYRK HLLKRCIHRA
AVLHRLKRMG KQDEGEDPLE KGLLEKQLGI LYGSSQDLAE EVEQVATGGY TLEPEKMVVP
VEIVKDMLLH SSPNQNRRTS Q
//