ID H2M806_ORYLA Unreviewed; 691 AA.
AC H2M806;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=Menin {ECO:0000256|ARBA:ARBA00021162};
GN Name=men1 {ECO:0000313|Ensembl:ENSORLP00000014617.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000014617.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000014617.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000014617.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000014617.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000014617.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR AlphaFoldDB; H2M806; -.
DR STRING; 8090.ENSORLP00000014617; -.
DR Ensembl; ENSORLT00000014618.2; ENSORLP00000014617.2; ENSORLG00000011655.2.
DR eggNOG; ENOG502QUYK; Eukaryota.
DR GeneTree; ENSGT00390000014237; -.
DR HOGENOM; CLU_018646_0_0_1; -.
DR InParanoid; H2M806; -.
DR TreeFam; TF323888; -.
DR Proteomes; UP000001038; Chromosome 18.
DR Bgee; ENSORLG00000011655; Expressed in blastula and 14 other cell types or tissues.
DR GO; GO:0000785; C:chromatin; IBA:GO_Central.
DR GO; GO:0035097; C:histone methyltransferase complex; IBA:GO_Central.
DR GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR GO; GO:0000403; F:Y-form DNA binding; IBA:GO_Central.
DR GO; GO:0045786; P:negative regulation of cell cycle; IBA:GO_Central.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd14456; Menin; 1.
DR InterPro; IPR007747; Menin.
DR PANTHER; PTHR12693; MENIN; 1.
DR PANTHER; PTHR12693:SF3; MENIN; 1.
DR Pfam; PF05053; Menin; 1.
PE 4: Predicted;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT REGION 525..629
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 667..691
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 526..559
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 612..626
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 691 AA; 76597 MW; D3F381AE614D2587 CRC64;
MFVAPPSRHP AACAGVSMMR TPPHLTFRQI ELRGKRSGTQ TKTCVWSGDY SDVEPSDPLS
RVPSDTMGLQ SAQKKLFPLR GIDGVVQLFD AELRKPEPDL ALLSLVLGFV EHFLAVNRVV
PINVPGVRFE PLEPDCPASC FPTVELGMIS ALYERFTAQI RGAVDLSQYR RTASASSREL
VKKVSDVIWN SLSRSYFKDR AHIQSLFSLI TGTKLDSTGV AFAVVAACQV LGLKDVHLAL
SEDHAWVIFG KDGEETAEVT WHGKGNEDRR GQTVTAGVNE KSWLYLKGSY MKCDRNMEVA
FMVCAINPSL DLHTDSSELL QLQQKLLWLL YERNDLERYP MAMGTLADLE DQDPIPGKGN
PLSIHLKAVQ SAQKYYNNEH IYPYMYLAGF HYRHKDVREA LKAWAAAAQV MQDYNYFRED
EEIYKEFFDI ANDVIPTLLK ETAAADSIGE EDGGETADKV STKQAAAFSA LHDPECFAHL
LRFYDGICKW EEGSPTPVLH VGWATYLVQS LSRFEAQVRQ KVSIITKEPE CQEDDDHSSE
DPRESRRRGP RRESKLEDQS SPPHAAPASP SGPPPTAAQP KKLGEGGVRR RSSSHGPCAG
DVDGTPKSPG ADSIPSPMSQ QQASPCPAGP MVVFQSEKMK GMKELLCAAK VNSSAIKLQL
TAQSQVQMKR QKSTPAGDYS MSFLKRQRKS L
//
