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Database: UniProt
Entry: H2M8W1_ORYLA
LinkDB: H2M8W1_ORYLA
Original site: H2M8W1_ORYLA 
ID   H2M8W1_ORYLA            Unreviewed;       714 AA.
AC   H2M8W1;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   28-MAR-2018, entry version 46.
DE   SubName: Full=Transient receptor potential cation channel, subfamily V, member 6 {ECO:0000313|Ensembl:ENSORLP00000014935};
GN   Name=trpv5 {ECO:0000313|Ensembl:ENSORLP00000014935};
OS   Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae;
OC   Oryziinae; Oryzias.
OX   NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000014935, ECO:0000313|Proteomes:UP000001038};
RN   [1] {ECO:0000313|Proteomes:UP000001038}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hd-rR {ECO:0000313|Proteomes:UP000001038};
RX   PubMed=17554307; DOI=10.1038/nature05846;
RA   Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B.,
RA   Yamada T., Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D.,
RA   Shimada A., Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A.,
RA   Asakawa S., Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K.,
RA   Sugano S., Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F.,
RA   Nomoto H., Nogata K., Morishita T., Endo T., Shin-I T., Takeda H.,
RA   Morishita S., Kohara Y.;
RT   "The medaka draft genome and insights into vertebrate genome
RT   evolution.";
RL   Nature 447:714-719(2007).
RN   [2] {ECO:0000313|Ensembl:ENSORLP00000014935}
RP   IDENTIFICATION.
RC   STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000014935};
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the transient receptor (TC 1.A.4) family.
CC       {ECO:0000256|SAAS:SAAS01006510}.
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DR   EMBL; BAAF04004059; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BAAF04004060; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_004078007.1; XM_004077959.2.
DR   STRING; 8090.ENSORLP00000014935; -.
DR   Ensembl; ENSORLT00000014936; ENSORLP00000014935; ENSORLG00000011919.
DR   GeneID; 101169560; -.
DR   KEGG; ola:101169560; -.
DR   eggNOG; KOG3676; Eukaryota.
DR   eggNOG; ENOG4110DG4; LUCA.
DR   GeneTree; ENSGT00550000074425; -.
DR   InParanoid; H2M8W1; -.
DR   KO; K04975; -.
DR   OMA; YFGQTVL; -.
DR   OrthoDB; EOG091G0314; -.
DR   TreeFam; TF314711; -.
DR   Proteomes; UP000001038; Chromosome 16.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005262; F:calcium channel activity; IEA:Ensembl.
DR   GO; GO:0055074; P:calcium ion homeostasis; IEA:Ensembl.
DR   GO; GO:0070509; P:calcium ion import; IEA:Ensembl.
DR   GO; GO:0042539; P:hypotonic salinity response; IEA:Ensembl.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:Ensembl.
DR   GO; GO:0051592; P:response to calcium ion; IEA:Ensembl.
DR   CDD; cd00204; ANK; 1.
DR   Gene3D; 1.25.40.20; -; 2.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR020683; Ankyrin_rpt-contain_dom.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR024862; TRPV.
DR   InterPro; IPR008344; TRPV5/TRPV6.
DR   PANTHER; PTHR10582; PTHR10582; 1.
DR   Pfam; PF12796; Ank_2; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   PRINTS; PR01765; ECACCHANNEL.
DR   SMART; SM00248; ANK; 6.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 2.
PE   3: Inferred from homology;
KW   ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023,
KW   ECO:0000256|SAAS:SAAS00933366};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001038};
KW   Ion channel {ECO:0000256|SAAS:SAAS00790162};
KW   Ion transport {ECO:0000256|SAAS:SAAS00790154};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW   Repeat {ECO:0000256|SAAS:SAAS00931009};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|SAAS:SAAS00788392}.
FT   TRANSMEM    330    354       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    389    407       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    428    448       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    496    515       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    557    578       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       45    264       ANK_REP_REGION. {ECO:0000259|PROSITE:
FT                                PS50297}.
FT   REPEAT      117    144       ANK. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00023}.
FT   REPEAT      164    196       ANK. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00023}.
SQ   SEQUENCE   714 AA;  80922 MW;  9361888677A9342E CRC64;
     MSPSLARSAP SELNHWWTQL RFRLQNKKGW NEMLDETFLL YTKNTNDIPL FYAAKTNSVG
     CIKKLLSCAS TNIFERGALG ETALHVAVIN DNLDAAVALM DGAPELINEP MTSELFQGVT
     PLHIAVVNRN INLVQHLISR GGDVCTPRVT GLYFRKRIGG LIYYGEHALS FAACVGNEDI
     VSMLIDAGAS TRVQDSRGNT VLHLLVLQPN KTIACQTMDL IMARDAELDQ PVPLDMVTNY
     RGLTPFKLAA KEGNTVVFQH LVNKRRVIQW SLGPLSSHLY DLTEIDSRAD NTSVLELIVA
     SPRREARGVL EVTPVRQLVS LKWNLYGKHY FRLLLFLYIL YIGCFTLCCV FRPLKDIPEN
     YTKSDSDYTI KIQKTLKESY VTYSDSLRLV GEVISVLGAV LILFLEIPDM IRVGAKRYFG
     QTALGGPFHV ILISYASLVV LLCVFRLCEV QGEAEVMALC LVLGWCNVMF FARGFEMLGP
     YVIMIQKIIF GDLTKFMWLS LIVLIGFSTS LWMVYMTQDP SSLPMYRSFP ITLFSEFELS
     LGMIDLPVDH TLKTPSIVHV VHVAFTFVCS TLLINLLIAM ISDTIWRVGQ ERDELWRTQV
     VATTLMLERR LPLCLWPRLG VCGLNYGLKE RWYLRVEDRN DAVMQKMRRY VKAFSKEDEK
     QKEGLEKADV TLRSQNKNSM RSKAQAGWEV IRQSTLGLEM EQEGPEEDQN IKFV
//
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