ID H2M9K0_ORYLA Unreviewed; 866 AA.
AC H2M9K0;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=T cell activation RhoGTPase activating protein b {ECO:0000313|Ensembl:ENSORLP00000015190.2};
GN Name=tagapb {ECO:0000313|Ensembl:ENSORLP00000015190.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000015190.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000015190.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000015190.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000015190.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000015190.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_004083609.2; XM_004083561.2.
DR AlphaFoldDB; H2M9K0; -.
DR STRING; 8090.ENSORLP00000015190; -.
DR Ensembl; ENSORLT00000015191.2; ENSORLP00000015190.2; ENSORLG00000012139.2.
DR GeneID; 101155816; -.
DR KEGG; ola:101155816; -.
DR CTD; 447809; -.
DR eggNOG; KOG4724; Eukaryota.
DR GeneTree; ENSGT00940000157993; -.
DR HOGENOM; CLU_014209_1_0_1; -.
DR InParanoid; H2M9K0; -.
DR OrthoDB; 2964977at2759; -.
DR TreeFam; TF331062; -.
DR Proteomes; UP000001038; Chromosome 24.
DR Bgee; ENSORLG00000012139; Expressed in pharyngeal gill and 12 other cell types or tissues.
DR GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
DR GO; GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd04402; RhoGAP_ARHGAP20; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR047886; ARHGAP20-like_RhoGAP.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR23179; T-CELL ACTIVATION RHO GTPASE ACTIVATING PROTEIN-RELATED; 1.
DR PANTHER; PTHR23179:SF26; T-CELL ACTIVATION RHO GTPASE-ACTIVATING PROTEIN; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038}.
FT DOMAIN 284..470
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 489..528
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 632..744
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 489..513
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 514..528
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 632..674
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 718..732
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 866 AA; 97614 MW; 582439B55F262EBC CRC64;
MEPLDYETAA LRRGSYDDAA SLRPHFRHLA QRRRSAPSLV LGKALGMPWS PIREEAPCWV
SVEQSPFVLG LTSENGELLL DECVQVSEGH KTRERHLFLF RDVIVFAKLK STATYRLKHR
VNLEDVWLYG FEDELENEED AMIAEFDLRL TIVLAWELSF CLVCFRSPEV KGHWCDTLRR
NILDARVRTG FASSPPDVLM KVLSGSIATK TLTGGGMEQM IDLPIEGDAK NFVLSKQLNS
QDERSTQLIE TKWSLVRNKM KLKKGSSNKA CRAESDSKAQ LFGQQLSKIC PDEYSLPKPV
MDLLVLLRKK GPSTEGVFRK PCNNKNMKDI RERLNCSMEV DYKDLPVVLI VGLLKSFLKE
LPGSLLRSEL YDKWIAALDI EDAQQRTQEI TKVVDDLPVA NKLLLQYLIC VLHHILKNAD
INKMDAHNLA VCIGPTLLQL DDTPLDGQRE KMQKVTELTQ FLIENCEILG ENIPSLLDTD
EDSVYSLHHD SAYDSTDPDG DGEAGEKRSS TDTERGSSSS YSSLSPYMTT STWQSDVTLN
AKTTINRRCS EPIIFLSAEL ASLCSHARSH DDCSVQRSTF DEQPLKKQIS DDSFLMKRND
TSPALSFPKL SSSPNVDLMP YMGKDCSCSS LESTASNQSE GSVFASSPKG SPGYTRRINV
TNQPLVATNT KQEIPRPITD EKKRSQSMRV TSKVLMRTRS LGAFSRSSYK KDSQKENSFP
CETLPEDSQS EADPSAESPR KPRPQSAIEV FKHVDSKLPS QPPSYEQAMQ NLGFPPQYRS
MTVQDAQKLE RRSRPSSVNY DFSTTEHVYN QDCFAQTAQE CVLERRQAFR PRAMSETVSM
GHHEVASRRC SQPVFEEFSY AKESYV
//
