ID H2MB01_ORYLA Unreviewed; 877 AA.
AC H2MB01;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 72.
DE RecName: Full=G-protein coupled receptors family 3 profile domain-containing protein {ECO:0000259|PROSITE:PS50259};
GN Name=LOC101166072 {ECO:0000313|Ensembl:ENSORLP00000015715.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000015715.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000015715.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000015715.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000015715.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000015715.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR AlphaFoldDB; H2MB01; -.
DR STRING; 8090.ENSORLP00000015715; -.
DR Ensembl; ENSORLT00000015716.2; ENSORLP00000015715.2; ENSORLG00000012554.2.
DR eggNOG; KOG1056; Eukaryota.
DR GeneTree; ENSGT00940000160473; -.
DR HOGENOM; CLU_005389_5_1_1; -.
DR InParanoid; H2MB01; -.
DR TreeFam; TF331269; -.
DR Proteomes; UP000001038; Chromosome 13.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR CDD; cd06364; PBP1_CaSR; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR000068; GPCR_3_Ca_sens_rcpt-rel.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24061; CALCIUM-SENSING RECEPTOR-RELATED; 1.
DR PANTHER; PTHR24061:SF1; VOMERONASAL TYPE-2 RECEPTOR 1; 1.
DR Pfam; PF00003; 7tm_3; 2.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF07562; NCD3G; 1.
DR PRINTS; PR00592; CASENSINGR.
DR PRINTS; PR00248; GPCRMGR.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..877
FT /note="G-protein coupled receptors family 3 profile domain-
FT containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017270369"
FT TRANSMEM 607..632
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 644..664
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 676..693
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 700..719
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 739..764
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 776..796
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 808..832
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 607..846
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
FT REGION 839..877
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 850..877
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 877 AA; 96294 MW; 51E3E4FEFC46B341 CRC64;
MDIISFALGF CALFCLHGSV SAESTCKLKA KFNLNSYKDV EKKKVVIGGM FPVHKRIASN
DGNTSRVPVS SGCEGFNFRT FRWTQTMLFA INEINKRNDL LPKTDLGYVI YDSCFTISKA
VEGTLTYLTG QDEAVPNYRC GNGPPLAALV GAGGSDLSIA TARILGLYHF PQVSYCSTCS
ALNNKFQFPT FLRTIPNDQH QSTAMAQMVL HFGWTWVGII AAEDDYGKYG IKDFKDQVEE
AGVCISFSET LPKVSSPAAI QRVVQTIVES TAKIIVVFSS DVDLSPLISE LLRHNVTNRT
WIASEAWITS ALINQPGVSP VLAGTLGFGV KRAEIPGLQR HLLDLDPFAD PLTEEFWETL
FNCTLDYGKA LRMAREVNRT LSRAGVPDGL CTGTESVAQL SNTYSDVSQL RITYSVYKAV
YAVAHALHHL EHCEPGNGPF VGKSCADITN FEPWQLMYYM KNVHFKVPNT EEEIYFVDGD
IEGYYDIINW QLGGDGEISY VTVGHYNGSA APEDRLHIRN DSIVWNNDES TPPRSVCSEN
CQPGTRKGIR QGEPVCCFDC IPCADGEISN TTNARECILC SGDFWSNDAH DTCVPKIIEF
LAFGEPLGIT LIVIAALGAL LTIAVGVVLI LHIDTPLVKA NDPLLSFSLL FSLVVTFLCS
IVFLGEPQHW SCMTSQVALA LGFALCLSSI MGGSPEGAAF LLFLNIQTCT VWLIILPPHP
VKNTSAQNIK IILECDEGSI VFICCVFAYD IVLALLAFVF AFIARKLEDH FSEAKCVTFG
MLVFFIVWIS FVPAYLSTRG KFMVAVQIFA ILASSFGLLF CIFLPKCYIL LVKPERNKEE
MMKPRPKPRD GTTTGTSASL ATTATEINAS TAVDDQD
//
