ID H2MBE4_ORYLA Unreviewed; 410 AA.
AC H2MBE4;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=Keratin 94 {ECO:0000313|Ensembl:ENSORLP00000015865.2};
GN Name=LOC101160141 {ECO:0000313|Ensembl:ENSORLP00000015865.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000015865.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000015865.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000015865.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000015865.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000015865.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|RuleBase:RU000685}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; H2MBE4; -.
DR Ensembl; ENSORLT00000015866.2; ENSORLP00000015865.2; ENSORLG00000012662.2.
DR eggNOG; ENOG502QTM6; Eukaryota.
DR GeneTree; ENSGT00940000155258; -.
DR HOGENOM; CLU_012560_8_1_1; -.
DR TreeFam; TF332742; -.
DR Proteomes; UP000001038; Chromosome 1.
DR Bgee; ENSORLG00000012662; Expressed in bone element and 13 other cell types or tissues.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.500; Single helix bin; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR002957; Keratin_I.
DR PANTHER; PTHR23239; INTERMEDIATE FILAMENT; 1.
DR PANTHER; PTHR23239:SF14; KERATIN, TYPE I CYTOSKELETAL 19; 1.
DR Pfam; PF00038; Filament; 1.
DR PRINTS; PR01248; TYPE1KERATIN.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW ECO:0000256|RuleBase:RU000685};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038}.
FT DOMAIN 100..410
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT COILED 104..138
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 196..282
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 309..336
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 410 AA; 45863 MW; EDF5400D65A21C77 CRC64;
LHFHSCETLV SSSSPLTSRK SAAMYNRSIA SGPGLTITRQ SRSYTSSAAP HKAHSVSGLS
FMGGSRISSA TGRTVSSSFG MGGGFDLSNA MDQSSVHLNE KATMQNLNDR LASYLDKVRS
LEAANAKLEK QIKEYYEQKG PAAQRDYSNY WAIINDLKDK INGATVQNAN ILLQIDNSKL
AADDFKTKFE HELMMRQSVE ADIANLRRLL DQTTLTKADL EMQIEGLQDE LAYLKKNHEE
ELAAMRSQLT GTVNVEVDAA PQQDLNKVME EIRAQYEAIT DKHRRDQEAW FTEKSSALSK
EVAVSTEVIQ TSKTEINDLR RTLQGLEIEL QSQLSMKGAL ENTLAETEGR FSAMLSGYQN
TINMLECELG QVRGSIEHQG QEYKMLLDIK TRLEQEIATY RRLLETEEAR
//
