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Database: UniProt
Entry: H2MBP2_ORYLA
LinkDB: H2MBP2_ORYLA
Original site: H2MBP2_ORYLA 
ID   H2MBP2_ORYLA            Unreviewed;      1871 AA.
AC   H2MBP2;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   25-OCT-2017, entry version 33.
DE   SubName: Full=Transient receptor potential cation channel subfamily M member 7 {ECO:0000313|Ensembl:ENSORLP00000015967};
GN   Name=TRPM7 {ECO:0000313|Ensembl:ENSORLP00000015967};
OS   Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae;
OC   Oryziinae; Oryzias.
OX   NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000015967, ECO:0000313|Proteomes:UP000001038};
RN   [1] {ECO:0000313|Proteomes:UP000001038}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hd-rR {ECO:0000313|Proteomes:UP000001038};
RX   PubMed=17554307; DOI=10.1038/nature05846;
RA   Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B.,
RA   Yamada T., Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D.,
RA   Shimada A., Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A.,
RA   Asakawa S., Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K.,
RA   Sugano S., Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F.,
RA   Nomoto H., Nogata K., Morishita T., Endo T., Shin-I T., Takeda H.,
RA   Morishita S., Kohara Y.;
RT   "The medaka draft genome and insights into vertebrate genome
RT   evolution.";
RL   Nature 447:714-719(2007).
RN   [2] {ECO:0000313|Ensembl:ENSORLP00000015967}
RP   IDENTIFICATION.
RC   STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000015967};
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSORLP00000015967}.
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DR   EMBL; BAAF04063855; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BAAF04063856; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 8090.ENSORLP00000015967; -.
DR   Ensembl; ENSORLT00000015968; ENSORLP00000015967; ENSORLG00000012746.
DR   eggNOG; KOG3614; Eukaryota.
DR   eggNOG; ENOG410XR5B; LUCA.
DR   GeneTree; ENSGT00760000119127; -.
DR   InParanoid; H2MBP2; -.
DR   OMA; KQGPTNP; -.
DR   OrthoDB; EOG091G0DHL; -.
DR   TreeFam; TF314204; -.
DR   Proteomes; UP000001038; Chromosome 3.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0005216; F:ion channel activity; IEA:InterPro.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:InterPro.
DR   GO; GO:0006812; P:cation transport; IEA:InterPro.
DR   GO; GO:0010961; P:cellular magnesium ion homeostasis; IEA:InterPro.
DR   GO; GO:0051262; P:protein tetramerization; IEA:InterPro.
DR   Gene3D; 1.20.5.1010; -; 1.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR011009; Kinase-like_dom.
DR   InterPro; IPR004166; MHCK_EF2_kinase.
DR   InterPro; IPR029601; TRPM7.
DR   InterPro; IPR032415; TRPM_tetra.
DR   InterPro; IPR037162; TRPM_tetra_sf.
DR   PANTHER; PTHR13800:SF8; PTHR13800:SF8; 1.
DR   Pfam; PF02816; Alpha_kinase; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF16519; TRPM_tetra; 1.
DR   SMART; SM00811; Alpha_kinase; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   PROSITE; PS51158; ALPHA_KINASE; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001038};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    867    885       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    929    950       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    956    974       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    986   1011       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1079   1101       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1122   1142       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1606   1836       Alpha-type protein kinase.
FT                                {ECO:0000259|PROSITE:PS51158}.
SQ   SEQUENCE   1871 AA;  211707 MW;  B63D114FEEFF88AA CRC64;
     QSQKPWIEVT FTKRECVYIL PVSKDPHRCL PGCQICQQLV RCCCGRLVRQ HAGFTASLAT
     KYSDVKLGEN PNPPMPELEE WSVEKHTEVS PTDAYGVINF QGGSHSYRAK YVRLSYDSRP
     ESVLRLMLKE WHMELPKILI SVHGGVQNFE LHPRIKQVVG KGLIKAAVTT GAWILTGGVN
     TGMWSEEKNH VGDALKEHCS RSAKKICTIG IAPWGVIENR NDLIGKDIIA PYQTLLNPLS
     KLNVLNNLHS HFLLVDDGTV GKYGAEVKLR RDLEKHINLQ RIHARIGQGV PVVALIFEGG
     PNVILTVLEY LQETPPVPVV VCEGTGRAAD ILAYVHKQTE EGGGLPDGVE TDIIATIKKT
     FNFSHSDAIH LFQMLMECMK SKELITVFDI SSEEQQDIDV AILKALLQGT NSSPFDQLVL
     TLAWDRVDIA KNHVFVYGQQ LLVSSLEQAM LDALVMDRVD FVKLLIENGV SMHRFLTINR
     LEELYNTKQS PNNPTLLHLV RDVKQSNLPP NYKITLIDVG LVIEYLMGGT YRCNYTRKRF
     RIIYNNLHGS NRRSGRHAAG PGSHFRKSHE AFSMQADKKE KTRHNHFIKT AQPYKPKVDS
     SAEQNKKRSK EEIVDIDDPE TRRFPYPFNE LLVWAVLMKR QKMSLFFWQH GEENMAKALV
     ACKLCRSMGY EAKKSDVVDD TSDKLKDYSN DFGTLAVDLL EQSFRQDETM AMKLLTYELK
     NWSNSTCLKL AVSSHLRPFV AHTCTQMLLS DMWMGRLNMR KNSWYKVILS ILVPPAILLL
     EYKSKAEMAH IPQSQDDHQM TMEDSEHNFQ NLHEDIQMAR FAHSLSHDHV ETKHDMEMHV
     RSRKLPLTRK IYAFYHAPIV KFWSNTLFYL GFLMLYTYVV LVKMIQAPST QEWVVIVYIF
     TSAIEKIREM FMSEAGKISQ KIKVWFSDYF NVSDFLAIVT FFIGCGLRLA GGDAFLPGRI
     VYCLNIIFWY VRLLDILAVN QQAGPYVMMI AKMVANMFYI VVIMLVVLLS YGVPRKAILY
     PNEEPSWTLA RDVVFQPYWM MYGEVYAYEI DVCANNSEDS VKPLCASAGV WLTPFLQAVY
     LFVQYILMVN LLIAFFNNVY MQVKSISNLV WKFQRYHFIM AYHEKPVLPP PFILLCHVYS
     LFCMCRKRKK ESTYGPKLFL TEEDQKKLHD FEEQCVETYF HEKDDQFHSG SEERIRLTSQ
     RVEAMSLQLK EVGNKVNFIK RSLHTLDSQI GHLQDLSALT VDTLKTLAAQ RASEATKVHT
     QITRELSLSK NVVPSIAPVS TDSKSSAIVK HSVGAYFGSS FPQTGGNIAD SLFGIGAELG
     AATESRRRVA PSFGEEQGLD PTTNLPVSPE RKALFGLEYL AAEAGSSGSA VSGAFVHSAG
     AVSPPELRLR GHSLTHNKLS RPQELHLSES PSSLPNVPSQ GAQFHISSTP SQPSGSSHPE
     LSLAGLHQQP LQRDSSSVEF GAFVGHKESL DLQQPTPIET SSRQQSPATQ TRSQVGYSVY
     SNCCKSGAEK KRCLKRAYLE LSATGWGRGG IALPQWSRPQ PKGDRTPGEE TLNAIGSPFK
     PMESYQYSAV ERNNLMRLSQ SIPFTPVPPR GEPVTVYRLE ESSPNIINNS MSSWSQRGFC
     AKIEFLSKEE MGGGLRRALK VLCTWSEYDI LKPGHLYIVK SFLPEVIQTW QSIYKEDTVL
     HLCLREIQQQ RAAQKLTFAF NQIRPKTIPY SPRFLEVFLL YCHSAGQWFA IEECITGEFR
     KFNNNNGDEI VPTNLLEETM LAFSHWTYEY TRGELLVLDL QGVGEILTDP SVIKSGEKGS
     YDMIFGPANL GDDAIRNFRA KHHCNSCCRK LKLPDLKRND YTPDKVTLPQ DDPPNSGGGV
     KESRQSMRLM L
//
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