ID H2MCK5_ORYLA Unreviewed; 700 AA.
AC H2MCK5;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Mitochondrial intermediate peptidase {ECO:0000313|Ensembl:ENSORLP00000016291.2};
GN Name=MIPEP {ECO:0000313|Ensembl:ENSORLP00000016291.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000016291.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000016291.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000016291.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000016291.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000016291.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|RuleBase:RU003435};
CC Note=Binds 1 zinc ion. {ECO:0000256|RuleBase:RU003435};
CC -!- SIMILARITY: Belongs to the peptidase M3 family.
CC {ECO:0000256|ARBA:ARBA00006040, ECO:0000256|RuleBase:RU003435}.
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DR RefSeq; XP_004075894.1; XM_004075846.2.
DR AlphaFoldDB; H2MCK5; -.
DR STRING; 8090.ENSORLP00000016291; -.
DR Ensembl; ENSORLT00000016292.2; ENSORLP00000016291.2; ENSORLG00000012997.2.
DR GeneID; 101155870; -.
DR KEGG; ola:101155870; -.
DR CTD; 4285; -.
DR eggNOG; KOG2090; Eukaryota.
DR GeneTree; ENSGT00950000183171; -.
DR HOGENOM; CLU_001805_0_2_1; -.
DR InParanoid; H2MCK5; -.
DR OrthoDB; 735202at2759; -.
DR TreeFam; TF105715; -.
DR Proteomes; UP000001038; Chromosome 13.
DR Bgee; ENSORLG00000012997; Expressed in ovary and 14 other cell types or tissues.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004222; F:metalloendopeptidase activity; IBA:GO_Central.
DR GO; GO:0006518; P:peptide metabolic process; IBA:GO_Central.
DR GO; GO:0006627; P:protein processing involved in protein targeting to mitochondrion; IBA:GO_Central.
DR CDD; cd06457; M3A_MIP; 1.
DR Gene3D; 3.40.390.10; Collagenase (Catalytic Domain); 1.
DR Gene3D; 1.10.1370.10; Neurolysin, domain 3; 1.
DR InterPro; IPR033851; M3A_MIP.
DR InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR InterPro; IPR024077; Neurolysin/TOP_dom2.
DR InterPro; IPR045090; Pept_M3A_M3B.
DR InterPro; IPR001567; Pept_M3A_M3B_dom.
DR PANTHER; PTHR11804:SF71; MITOCHONDRIAL INTERMEDIATE PEPTIDASE; 1.
DR PANTHER; PTHR11804; PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED; 1.
DR Pfam; PF01432; Peptidase_M3; 1.
DR SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU003435};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU003435};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049,
KW ECO:0000256|RuleBase:RU003435};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|RuleBase:RU003435};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU003435}.
FT DOMAIN 241..683
FT /note="Peptidase M3A/M3B catalytic"
FT /evidence="ECO:0000259|Pfam:PF01432"
SQ SEQUENCE 700 AA; 79357 MW; D215241525178558 CRC64;
MSACKRLVCL VKQRSLWAPT RRNVSTWSPV GTAFNARAHK RQDFFEKSVG LFGVPELSSP
EGFQVAAKTA LRNTERLVGQ ACSSPAGVGT VECFDQLSDE LCKVADLADF IKVAHPDPEY
REAAEKTCIE IGTVVEKLNT NVELCQSLKK LLDDPKIVAQ LDPDTRRVAE LFMFDFEISG
IHLDEKLRKE AVGLHVKLLD LNNAFLIGSH TPNRIAKAAI PQHLHMHFGS EGSFIQVGGL
HADSPDDLLR EIAYRVYLYP NADLLDCLEE LLRCRYKLAK LVGYKSYGHR ALKGTMAKSP
ETVMSFLQLL TDKLSDRTKK DFQMMRDMKK KLNPRNPELM AWDHPFLSGV LRAERFNIEP
SLYSPYLSLG GCMEGLNSLF SQLYGVSLMS EHPSAGEVWS EDVRKLAVVH ETEGLLGHIY
CDFFQRSDKP HQDCHFTIRG GRWCQDAGRY QLPVVVLMLS LPHPTKSAPT LLTPGMMENL
FHEMGHAMHS MLGRTRYQHV TGTRCATDFA EVPSILMEYF ATDYRVLSQF ARHYQTGQPL
PESMVARLSE SKKVCGAADT QLQIFYAVLD QIYHSKPQNR STTEILKDMQ QKFYGLPYTP
NTAWQLRFSH LIGYGAKYYS YLMSRAVASM VWKQCFIQDP LNRAMGERYR REMLAHGGAK
EPMLMVEGML QRRPTTEDFV EALVSELDPN FDTFIMDSES
//
