ID H2MDI5_ORYLA Unreviewed; 688 AA.
AC H2MDI5;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=FERM domain containing kindlin 2 {ECO:0000313|Ensembl:ENSORLP00000016630.2};
GN Name=fermt2 {ECO:0000313|Ensembl:ENSORLP00000016630.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000016630.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000016630.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000016630.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000016630.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000016630.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the kindlin family.
CC {ECO:0000256|ARBA:ARBA00008052}.
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DR RefSeq; XP_011488550.1; XM_011490248.1.
DR AlphaFoldDB; H2MDI5; -.
DR Ensembl; ENSORLT00000016631.2; ENSORLP00000016630.2; ENSORLG00000013270.2.
DR GeneID; 101155069; -.
DR CTD; 10979; -.
DR GeneTree; ENSGT00390000013444; -.
DR HOGENOM; CLU_011611_1_0_1; -.
DR OrthoDB; 5399911at2759; -.
DR Proteomes; UP000001038; Chromosome 22.
DR Bgee; ENSORLG00000013270; Expressed in animal zygote and 14 other cell types or tissues.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:InterPro.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd17181; FERM_F0_KIND2; 1.
DR CDD; cd17184; FERM_F1_KIND2; 1.
DR CDD; cd01237; PH_fermitin; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR037843; Kindlin/fermitin.
DR InterPro; IPR040790; Kindlin_2_N.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR037837; PH_Kindlin/fermitin.
DR PANTHER; PTHR16160; FERMITIN 2-RELATED; 1.
DR PANTHER; PTHR16160:SF11; FERMITIN FAMILY HOMOLOG 2; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF18124; Kindlin_2_N; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00295; B41; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR SUPFAM; SSF47031; Second domain of FERM; 2.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038}.
FT DOMAIN 389..485
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 141..166
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 141..158
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 688 AA; 79009 MW; 3B7E878BD4CD3336 CRC64;
MALDGIRMPD GCYADGTWEL KMHVTDLHRD VSLRVTGEIH IGGVMLKLVE KLDVKKDWSD
HALWWEKKKT WLLKTHWTLD KYGIQADARL LFTPQHKVLR LQLPNMKHMK VKVNFSDRVF
KAVSDICKTF NIRHPEELSL LRKPRDPKKK KKKLEEAEED DLELEGPLLT PGSASEIIYI
GPVKGSIYSS PGLYSKTMTP TYDSRDGSPL SPTSAWFGDS PLSEGNPSIL AVSQPISSPD
ILVKLYKPQS LLDKAKINQG WMDSSRSLME QDVKENEVLL LRFKYHSFFD LNPKYDAIRV
NQLYEQAKWA ILLEEIECTE EEMMMFAALQ YHINKLSIMS TDNHMNNSEK EVDEVDAALS
DLEITLEGGK TSNTLGDITS IPELADYVKV FKPKKLTLKG YKQYWCTFKD ITISCYKSKE
EAHGTPSYQM NLRGCEVTPD VNISGQKFNI KLLIPVADGM NEIWLRCDTE KQYAHWMAAC
RLASKGKTMA DSSYNLEVQN ILSFLKMQHM NPDPQFIEPI TTDINPECLV SPRYLKKYKN
KQISARILEA HQNVAQMSLI EAKMRFIQAW QSLPEFGITH FLAKFQGGKK EELIGITYNR
LIRMDAHTGD AIKTWRFSNM KQWNVNWEIK MVTVEFADEP SLAFICAEVD CKVVHEFIGG
YIFLSTRAKD QNESLDEEMF YKLTSGWV
//
