ID H2ME99_ORYLA Unreviewed; 627 AA.
AC H2ME99;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=Choline/carnitine acyltransferase domain-containing protein {ECO:0000259|Pfam:PF00755};
GN Name=zgc:154046 {ECO:0000313|Ensembl:ENSORLP00000016903.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000016903.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000016903.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000016903.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000016903.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000016903.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the carnitine/choline acetyltransferase family.
CC {ECO:0000256|ARBA:ARBA00005232, ECO:0000256|RuleBase:RU003801}.
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DR RefSeq; XP_011477719.1; XM_011479417.1.
DR AlphaFoldDB; H2ME99; -.
DR STRING; 8090.ENSORLP00000016903; -.
DR Ensembl; ENSORLT00000016904.2; ENSORLP00000016903.2; ENSORLG00000013476.2.
DR GeneID; 101160324; -.
DR eggNOG; KOG3717; Eukaryota.
DR GeneTree; ENSGT01060000248556; -.
DR HOGENOM; CLU_013513_5_0_1; -.
DR InParanoid; H2ME99; -.
DR OrthoDB; 1429709at2759; -.
DR TreeFam; TF313836; -.
DR Proteomes; UP000001038; Chromosome 9.
DR Bgee; ENSORLG00000013476; Expressed in muscle tissue and 14 other cell types or tissues.
DR GO; GO:0005777; C:peroxisome; IBA:GO_Central.
DR GO; GO:0004092; F:carnitine O-acetyltransferase activity; IBA:GO_Central.
DR GO; GO:0019254; P:carnitine metabolic process, CoA-linked; IBA:GO_Central.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR Gene3D; 3.30.559.70; Choline/Carnitine o-acyltransferase, domain 2; 1.
DR InterPro; IPR000542; Carn_acyl_trans.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR039551; Cho/carn_acyl_trans.
DR InterPro; IPR042231; Cho/carn_acyl_trans_2.
DR PANTHER; PTHR22589:SF50; CARNITINE O-ACETYLTRANSFERASE; 1.
DR PANTHER; PTHR22589; CARNITINE O-ACYLTRANSFERASE; 1.
DR Pfam; PF00755; Carn_acyltransf; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
DR PROSITE; PS00440; ACYLTRANSF_C_2; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315,
KW ECO:0000256|RuleBase:RU003801}; Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003801}.
FT DOMAIN 40..609
FT /note="Choline/carnitine acyltransferase"
FT /evidence="ECO:0000259|Pfam:PF00755"
FT COILED 480..507
FT /evidence="ECO:0000256|SAM:Coils"
FT ACT_SITE 344
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR600542-1"
SQ SEQUENCE 627 AA; 71318 MW; 16C27E5D94B760AC CRC64;
MLGFFVRAAR PSVVNPCRLL RAVTQIPERS YVHQEGLPKL PVPPLKQTCE RYLAILEPIV
SKEELEHTRQ LVQEFLKGGV GERLQKELER RARKTDNWLS EWWMQSAYLD CRMPLAVYTS
PGVVLPRLHF QDRQGQMRFA AKLIAGVLDF KRMIDTETLP VEYLSGKSLC MDQYYQILSS
CRIPGPKRDT VVNHAVGKTP PTHIAVVHNF QFFVLDVYNS DGTPLTVDQI YMQLEKIWNS
SLQTNKEPIG ILTSQHRNTW GKAYNNLIKD KTNKESVRAI QKSIFAVCLD APLPRVSDEL
YLSRVTAQML HGGGARWNSG NRWFDKTLQF IVGEDGSCGL VYEHAPAEGP PIVFLIDHVV
KYMQNIQMVR SPMVPLPMPQ KLRFNITPEI KRDIENAKQN MNIMVHDLDV KVLRFPHFGK
KLPKQYKLSP DGFVQMALQL AYFRMYNCCC STYESASLRM FKYGRTDAIR STTADSLQFV
KAMQDSTKQK EEKVAMLEKA VQTHKENTYN AIHGQAIDRH LLGLRMQSIT DLTSMPEIFM
DTSYAVANHF NLSTSQVGSK TDCVMCFGPV VPDGYGVCYN PMDEHINIAI TAFNSCEETN
AANFAQAVED SLLDMRALLE DAAVTRQ
//