ID H2MGK5_ORYLA Unreviewed; 503 AA.
AC H2MGK5;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=Ectonucleoside triphosphate diphosphohydrolase 2 {ECO:0000313|Ensembl:ENSORLP00000017743.2};
GN Name=ENTPD2 {ECO:0000313|Ensembl:ENSORLP00000017743.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000017743.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000017743.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000017743.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000017743.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000017743.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the GDA1/CD39 NTPase family.
CC {ECO:0000256|ARBA:ARBA00009283, ECO:0000256|RuleBase:RU003833}.
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DR RefSeq; XP_004075158.1; XM_004075110.2.
DR AlphaFoldDB; H2MGK5; -.
DR STRING; 8090.ENSORLP00000017743; -.
DR Ensembl; ENSORLT00000017744.2; ENSORLP00000017743.2; ENSORLG00000014146.2.
DR GeneID; 101169627; -.
DR KEGG; ola:101169627; -.
DR CTD; 954; -.
DR GeneTree; ENSGT01100000263542; -.
DR InParanoid; H2MGK5; -.
DR OrthoDB; 180318at2759; -.
DR Proteomes; UP000001038; Chromosome 12.
DR Bgee; ENSORLG00000014146; Expressed in pharyngeal gill and 12 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004382; F:GDP phosphatase activity; IBA:GO_Central.
DR GO; GO:0045134; F:UDP phosphatase activity; IBA:GO_Central.
DR GO; GO:0009134; P:nucleoside diphosphate catabolic process; IBA:GO_Central.
DR CDD; cd00012; NBD_sugar-kinase_HSP70_actin; 1.
DR Gene3D; 3.30.420.40; -; 1.
DR Gene3D; 3.30.420.150; Exopolyphosphatase. Domain 2; 1.
DR InterPro; IPR000407; GDA1_CD39_NTPase.
DR PANTHER; PTHR11782; ADENOSINE/GUANOSINE DIPHOSPHATASE; 1.
DR PANTHER; PTHR11782:SF33; ECTONUCLEOSIDE TRIPHOSPHATE DIPHOSPHOHYDROLASE 2; 1.
DR Pfam; PF01150; GDA1_CD39; 1.
DR PROSITE; PS01238; GDA1_CD39_NTPASE; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|PIRSR:PIRSR600407-2};
KW Hydrolase {ECO:0000256|RuleBase:RU003833};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|PIRSR:PIRSR600407-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..29
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 30..503
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017339810"
FT TRANSMEM 467..489
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT ACT_SITE 165
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR600407-1"
FT BINDING 204..208
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR600407-2"
SQ SEQUENCE 503 AA; 55528 MW; 4292E01F43EDD1E7 CRC64;
MARRSRLSFA SIALLVFALV VILLLTVPTQ DVQEAPGFMY GIVLDAGSSH TALFIYRWPA
DKQNGTGVVT QHAECHVQGE GISSYAGQKG EAGESLVACL DQAVRDIPKD KHQLTPVYLG
ATAGMRLLNI SNPKQSDQIL KEVGDKIKSY PFKFEGAAIL SGQEEGAYGW VTVNYLLENF
IKYGFIGRWM SPGRATVGAL DLGGASTQIT FATQERVEGK QNMMEMRLYG HKYSLYTHSF
LCYGINQVYN RMLAHLVKSQ GYVQSVTNPC YPPDVNTTLK MKDVFSSPCT EEHRPKPYNP
EGTLTVKGSG NYQQCEENMS NMFSFEDCPF SQCSFNGISQ PNVTGNFMAF STFFYVHSSL
RKLTGKPVNT PQQLQEAAQT TCSMTLSQMS NQIPDQGPHW MNYCTASVFI KTLVLRGYAF
DNSTFPQISF QKKAGDTSVG WALGYILNLS NLLPAEKVGL RKALTPGVWG TLIFLFALLV
AAALGFLLYR VQSERKDSDE GAI
//
