ID H2MH59_ORYLA Unreviewed; 621 AA.
AC H2MH59;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Kelch like family member 22 {ECO:0000313|Ensembl:ENSORLP00000017957.2};
GN Name=KLHL22 {ECO:0000313|Ensembl:ENSORLP00000017957.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000017957.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000017957.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000017957.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000017957.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000017957.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; H2MH59; -.
DR STRING; 8090.ENSORLP00000017957; -.
DR Ensembl; ENSORLT00000017958.2; ENSORLP00000017957.2; ENSORLG00000014319.2.
DR eggNOG; KOG4441; Eukaryota.
DR GeneTree; ENSGT00940000159598; -.
DR InParanoid; H2MH59; -.
DR TreeFam; TF328485; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000001038; Chromosome 9.
DR Bgee; ENSORLG00000014319; Expressed in testis and 14 other cell types or tissues.
DR GO; GO:0031463; C:Cul3-RING ubiquitin ligase complex; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0072686; C:mitotic spindle; IBA:GO_Central.
DR GO; GO:0005827; C:polar microtubule; IBA:GO_Central.
DR GO; GO:1904263; P:positive regulation of TORC1 signaling; IBA:GO_Central.
DR GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR GO; GO:0006513; P:protein monoubiquitination; IBA:GO_Central.
DR Gene3D; 1.25.40.420; -; 1.
DR Gene3D; 2.120.10.80; Kelch-type beta propeller; 1.
DR InterPro; IPR011705; BACK.
DR InterPro; IPR017096; BTB-kelch_protein.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR015915; Kelch-typ_b-propeller.
DR InterPro; IPR006652; Kelch_1.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR PANTHER; PTHR45632:SF5; KELCH-LIKE PROTEIN 22; 1.
DR PANTHER; PTHR45632; LD33804P; 1.
DR Pfam; PF07707; BACK; 1.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF01344; Kelch_1; 4.
DR Pfam; PF13964; Kelch_6; 1.
DR PIRSF; PIRSF037037; Kelch-like_protein_gigaxonin; 1.
DR SMART; SM00875; BACK; 1.
DR SMART; SM00225; BTB; 1.
DR SMART; SM00612; Kelch; 5.
DR SUPFAM; SSF117281; Kelch motif; 1.
DR SUPFAM; SSF54695; POZ domain; 1.
DR PROSITE; PS50097; BTB; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Kelch repeat {ECO:0000256|ARBA:ARBA00022441};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 90..157
FT /note="BTB"
FT /evidence="ECO:0000259|PROSITE:PS50097"
SQ SEQUENCE 621 AA; 69893 MW; F6FBB8E3BC698FDD CRC64;
MSANATEHNT RENKCSWSAG SALSHVGTGQ IKAMKPEGQR VVMAEDGAKS AVGGRAGSSD
CPGRQIFRSS AHFRSLQDGL LSLRQMGILF DVVLVVEGRP IQAHRILLAA ACDYFRGMFA
GGLRETQQKE ILIHGVSHMA MKKLLDYIYT AEIELDLDCV QEVLIAATMV QLESVIGFCC
DFLYSWLDDS SILEVLQLAD LFELQQLKDR VRSYILNNIQ TLSRMDVYRK LPEEEIFRAL
SSDQLQVTSE NEVYEAALYF HFSPEEVEAD KVHLQVSLKD NLKMLEAVRF CLIERRVLQR
LHSRLDQCPL KQSVSAALRY HEQELWQPVL QSPLTQPRST LYCILGFGGM FSSTSLTDKK
NLFQVFHPSW GEWRTLPSAQ SPRMSNQGVA VLNNFVYLIG GDKNTNGFRA ENCCWRYDPR
HNSWASIQPL QQQHADHCVC VVGGHIYAIG GRDYSCELDS VERYDPSTNM WQFVSSLKRE
VYAHAGAVVD GKIYITCGRR GMAYLRETYC FDPAANHWAV CAEGPVERAW HGMAAVNGRI
YVIGGSNHER GYRRDVNKVA CFDPAANSWT LVAPLPSGHG EPGIAVLDCR IYVLGGRSHD
KGRRMKYVHV YNTDADEWDG Q
//
