ID H2MHJ7_ORYLA Unreviewed; 702 AA.
AC H2MHJ7;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 68.
DE RecName: Full=formate--tetrahydrofolate ligase {ECO:0000256|ARBA:ARBA00012295};
DE EC=6.3.4.3 {ECO:0000256|ARBA:ARBA00012295};
GN Name=mthfd1l {ECO:0000313|Ensembl:ENSORLP00000018106.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000018106.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000018106.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000018106.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000018106.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000018106.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: One-carbon metabolism; tetrahydrofolate interconversion.
CC {ECO:0000256|ARBA:ARBA00004777}.
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DR AlphaFoldDB; H2MHJ7; -.
DR Ensembl; ENSORLT00000018107.2; ENSORLP00000018106.2; ENSORLG00000014449.2.
DR eggNOG; KOG4230; Eukaryota.
DR GeneTree; ENSGT00940000157477; -.
DR HOGENOM; CLU_003601_0_0_1; -.
DR TreeFam; TF300623; -.
DR UniPathway; UPA00193; -.
DR Proteomes; UP000001038; Chromosome 24.
DR Bgee; ENSORLG00000014449; Expressed in gastrula and 9 other cell types or tissues.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0035999; P:tetrahydrofolate interconversion; IEA:UniProtKB-UniPathway.
DR CDD; cd00477; FTHFS; 1.
DR Gene3D; 1.10.8.770; -; 1.
DR Gene3D; 3.10.410.10; Formyltetrahydrofolate synthetase, domain 3; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR HAMAP; MF_01543; FTHFS; 1.
DR InterPro; IPR000559; Formate_THF_ligase.
DR InterPro; IPR020628; Formate_THF_ligase_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF01268; FTHFS; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00721; FTHFS_1; 1.
DR PROSITE; PS00722; FTHFS_2; 1.
PE 3: Inferred from homology;
KW One-carbon metabolism {ECO:0000256|ARBA:ARBA00022563};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..702
FT /note="formate--tetrahydrofolate ligase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017452054"
SQ SEQUENCE 702 AA; 75821 MW; CACDFE2CE15F78BE CRC64;
PLKVLMLCMF CLHQVMHADA LVLLGAESME IPSTWVRPGA AIIRCESILI SNVVQSCSRW
LQEQQYRPWH LHTLKLQPLN PVPSDIEISR AQTPKPIDQL AAEIGLLPEE LEPYGRSKAK
VRLSLLDRLH SQPDGKYILV AGITPTPLGE GKSTVTIGLV QAMSAHLKLN SFACLRQPSQ
GPTFGVKGGA AGGGYAQVIP MEEFNLHLTG DIHAITAANN LVAAAIDARM LHEATQSDKA
LFNRLVPSVN GVRKFSPIQI SRLQGLGIHK TDPASLTPQE VSAFARLDLD PSKITWHRVV
DTNDRFLRKI TVGQASTEKG QTRETGFDIA VASEIMAILA LSDNLGDMRG RLGRMVVGTS
RSGKPVTAED LGVSGAVAVL MKDAIKPTLM QTLEGTPVFV HAGPFANIAH GNSSVLADKL
ALKLVGQDGF VVTEAGFGAD IGMEKFFNIK CRASGLKPNV VVLVATVRAL KMHGGGPNVS
AGAPLPREYI DENLSLVARG CRSNLRKQIQ IAKLFGVPVV VALNAFRTDT PAEIDLVCQI
AKECGASDAV SCQHWSQGGR GCLELAQAVK EAARQPTNFQ FLYKTEMPIV EKIRTIAQKV
YGADDIQVSP EVQRKIDYYN HQGYGSLPIC MAKTHLSLSH MPDKKGAPTG FVLPIRDIRA
SIGAGFIYPL VGTMSTMPGL PTRPCFYDID IDPVTEDIIG LF
//
