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Database: UniProt
Entry: H2MHJ9_ORYLA
LinkDB: H2MHJ9_ORYLA
Original site: H2MHJ9_ORYLA 
ID   H2MHJ9_ORYLA            Unreviewed;       852 AA.
AC   H2MHJ9;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   07-JUN-2017, entry version 27.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   Name=LOC101156445 {ECO:0000313|Ensembl:ENSORLP00000018108};
OS   Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae;
OC   Oryziinae; Oryzias.
OX   NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000018108, ECO:0000313|Proteomes:UP000001038};
RN   [1] {ECO:0000313|Proteomes:UP000001038}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hd-rR {ECO:0000313|Proteomes:UP000001038};
RX   PubMed=17554307; DOI=10.1038/nature05846;
RA   Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B.,
RA   Yamada T., Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D.,
RA   Shimada A., Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A.,
RA   Asakawa S., Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K.,
RA   Sugano S., Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F.,
RA   Nomoto H., Nogata K., Morishita T., Endo T., Shin-I T., Takeda H.,
RA   Morishita S., Kohara Y.;
RT   "The medaka draft genome and insights into vertebrate genome
RT   evolution.";
RL   Nature 447:714-719(2007).
RN   [2] {ECO:0000313|Ensembl:ENSORLP00000018108}
RP   IDENTIFICATION.
RC   STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000018108};
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSORLP00000018108}.
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DR   EMBL; BAAF04058827; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BAAF04058828; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BAAF04058829; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 8090.ENSORLP00000018108; -.
DR   Ensembl; ENSORLT00000018109; ENSORLP00000018108; ENSORLG00000014447.
DR   eggNOG; KOG2189; Eukaryota.
DR   eggNOG; COG1269; LUCA.
DR   GeneTree; ENSGT00390000004941; -.
DR   InParanoid; H2MHJ9; -.
DR   OMA; WTAYDAH; -.
DR   OrthoDB; EOG091G01BI; -.
DR   TreeFam; TF300346; -.
DR   Proteomes; UP000001038; Chromosome 19.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   GO; GO:0071466; P:cellular response to xenobiotic stimulus; IEA:Ensembl.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001038};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    410    434       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    454    473       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    551    569       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    581    604       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    647    673       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    791    813       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED       94    121       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   852 AA;  97159 MW;  928199BC87AE7845 CRC64;
     MGELFRSEEM TLAQLFLQSE AAYCCVSELG ELGMVQFRDL NPDVNVFQRK FVNEVRRCEE
     MDRKLRFVEK EIKKVGIPMV DTGENPEVPF PRDMIDLEAT FEKLENELKE INTNQEALKK
     NFLELTELKH ILHRTQQFFD EMEDPNLLEE SSALMEKTLH AVGTSVFPHL LVSFRPHRFV
     AGVISRERIP TFERMLWRVC RGNVFLRKAE IEDPLEDPTT GDQVHKSVFI IFFQGDQLKN
     RVKKICEGFR ASLYPCPETP QERKEMLAGV NSRIDDLQMV LNQTEDHRQR VLQAASKTMR
     VWFIKVRKMK AIYHTLNLCN IDVTQKCLIA EVWCPVSDLD SIQFALRRGT ERSGSTVPSI
     LNRMQTKQTP PTFNKTNKFT SGFQNIVDAY GIGNYREINP APYTIITFPF LFAVMFGDMG
     HGLLMLCAAL YLVLRESRIL AQKIDNEMFN MVFAGRYIIL LMGVFSVYTG VIYNDCFSKS
     LNMFGSGWSV RPMFSAKGAN WTFTTLKENT VLQLDPAVPG VFNGPYPLGI DPVWNIATNK
     LTFLNSFKMK MSVILGVIHM LFGVSLSLFN HLYFKKPLNI FLGFIPEIVF MFSLFGYLVL
     LVFYKWTAYD AFTSKDAPSL LIHFINMCLF NYNDPTNKPL YRGQMGIQIL LVLIALACVP
     CMLILDTALV TFVSSHRRGT WTANISPSRV TTQSVQLSEF QETASSVGNL LNGTSEWDLR
     KRGSDGQKNK FDFGDVAVHQ AIHTIEYCLG CISNTASYLR LWALSLAHAQ LSEVLWSMVM
     HLGLSSRSGG GFFGLSIIFA AFAMLTVAIL LIMEGLSAFL HALRLHWVEF QNKFYTGQGF
     KFVPFSFESI LE
//
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