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Database: UniProt
Entry: H2MHV7_ORYLA
LinkDB: H2MHV7_ORYLA
Original site: H2MHV7_ORYLA 
ID   H2MHV7_ORYLA            Unreviewed;      2008 AA.
AC   H2MHV7;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   20-DEC-2017, entry version 37.
DE   RecName: Full=Voltage-dependent L-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
OS   Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae;
OC   Oryziinae; Oryzias.
OX   NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000018227};
RN   [1] {ECO:0000313|Ensembl:ENSORLP00000018227}
RP   IDENTIFICATION.
RC   STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000018227};
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. The isoform alpha-1C
CC       gives rise to L-type calcium currents. Long-lasting (L-type)
CC       calcium channels belong to the 'high-voltage activated' (HVA)
CC       group. They are blocked by dihydropyridines (DHP),
CC       phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA
CC       (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-
CC       GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA).
CC       Calcium channels containing the alpha-1C subunit play an important
CC       role in excitation-contraction coupling in the heart. Binding of
CC       calmodulin or CABP1 at the same regulatory sites results in an
CC       opposit effects on the channel function.
CC       {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSORLP00000018227}.
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DR   EMBL; BAAF04011002; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BAAF04011003; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BAAF04011004; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BAAF04011005; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BAAF04011006; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BAAF04011007; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BAAF04011008; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 8090.ENSORLP00000018227; -.
DR   Ensembl; ENSORLT00000018228; ENSORLP00000018227; ENSORLG00000014537.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128247; -.
DR   InParanoid; H2MHV7; -.
DR   OMA; LALVEWK; -.
DR   OrthoDB; EOG091G0TKO; -.
DR   TreeFam; TF312805; -.
DR   Proteomes; UP000001038; Chromosome 7.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   GO; GO:0050808; P:synapse organization; IEA:Ensembl.
DR   InterPro; IPR031688; CAC1F_C.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR005446; VDCC_L_a1su.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16885; CAC1F_C; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01630; LVDCCALPHA1.
DR   SMART; SM01062; Ca_chan_IQ; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001038};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM     47     66       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     86    105       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    117    134       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    192    215       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    271    292       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    304    326       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    496    514       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    534    556       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    622    644       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    695    717       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    821    839       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    851    874       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    938    971       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1021   1042       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1063   1089       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1143   1161       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1173   1193       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1272   1290       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1364   1387       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1521   1555       Ca_chan_IQ. {ECO:0000259|SMART:SM01062}.
FT   COILED     1543   1563       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2008 AA;  224099 MW;  B33C5893953ADA86 CRC64;
     SARKRGGGAK KAMQANKSAL RAPRALCCLT LSNPIRMAAL ALVEWKPFDI FILLAIFANC
     VAMGVTKPFP DDDSNPTNHQ LEQVEYVFLV IFTIETFTKI LAYGLVMHPS AYIRSGWNLL
     DFVIVIVGLF SVMAEGMTDH KPGEAHHAAG KPGGLDVKAL RAFRVLRPLR LVSGVPSLQI
     VLNSIMKAMV PLLHIGMLVM FVIIIYAIIG LELFIGRMHK SCYDISTGLM VEDDPSPCAF
     AGSGRFCVTN GTECRGKWEG PNGGITNFDN IFFAMLTVFQ CITMEGWTDV LYWMNDAIGF
     EIPWIYFVSL VIFGSFFIIN LVLGVLSGEF SKEREKAVAR GELQKAQESK QMEEDMIGYM
     DWLIEAEDVD EEGNNAGGKP SRANSAGPPR SKPRPPPPNA SPRRARSGLD GTEAANRPGK
     PPMASAETPT RQPPLPRTIP RSMLCFLRIG AVSLWPTWQI LYCTSQRSSF SNVFSDQLCQ
     LNHTFRKNCR VAVKTTNFYW LVLLLVFLNT VASASEHYGQ PKWLTELQER ANKILLLLFT
     LEMLMKMYAF GLQIYFMALF NRFDCFVVCG GILETLLVEM DVIPPIGISV LRCIRLLRIF
     KMTRHWAALS DLVTSLLNSM KAICSLLLLL FLFLIIFALL GMQLFGGKFN FDETQMKRST
     FDSFPQALLT CFQILTGEDW NAVMYDGIMA YGGPIFPNMV VCIYFVILFV CGNYILLNVF
     LAIAVDNLAG GGEKKKVDFL HRQTPYSLVC PFFLQQNEED DWPENEELRA IEGLEGVAPL
     KPEFSGPKEK IVPIPDGSSF FILGKKNCLR VACHNLIHHP YFTNFILIFI ILSSISLAAE
     DPIKSHSFRN IVLGYADYVF TSVFTVEIVL KMTVYGAFLH TGSFCRNAFN LLDLLVVSVS
     LTSFFLHSSA ISVVKILRVL RVLRPLRAIN RAKGLKNVVQ CVFVAIRTIG NILIVTTLLQ
     FMFACIGVQL FKGRFYSCTD EAKHTPEECK GTFVVYKDGD MNHPMVKERI WENSDFNFDN
     VLMGMLALFT VSTFEGWPLL LYRAVDANAI NRGPIYNYRV EISIFFIIYI IIIAFFMMNI
     FVGFVIITFR EQGEAEFKNC ELNKNQRQCV YYALKAQPIK IYIPKNPSQL KFWRIINSSQ
     FEYVMFVLIL GNTLTLAIQH YEQSKLFTSV MDILNMIFTV VFTIEMIIKL LALRAHHYFI
     DPWNSFDALI VVGSVLDIAV SEGGGSGGGK GEHAKVSITF FRLFRVLRLV KLLSKGEGIR
     TLLWTFVKSL QALPYVGLLI AMIFFIYAVI GMQMFGKIAV DDETEINRNC NFQTFFMAVL
     VLFRCATGEQ WQQIMLGALP GRRCDPESDT EPGEEFTCGS NLAYIYFISF FMLCAYLIIN
     LFIAVIMDNF EYLTRDWTVL GTHHLDEFKR VWSDYDPEAT GRIKHIDVVT MLRRIQPPLG
     FGKLCPHRVA CKRLVAMNVP LHSDGTVTFN ATLFALVRTS LKIKTEGPID KQNEELKIII
     KKLWKRTKPK LIDEVIPPPR GDEVTCGKVY ASFLIQDYFK KYRKRKERER KSKKKDKAAA
     LQQGLRTLHD LAPEMRLAMA CDLDEEEATE GEMTGDEIFD INGGVITEQV NGLQEHQKPG
     SELAGVSVVT EQPLRSEPLP VSVVSISESP LPPPPDLLVE SEPVAEVAAS AATEQFFSNE
     LEAASLASVD GYSYPEPMSP LPTDSGFNGQ SLDMTSSIGE IPYDTHIPDD FVDHGYSDGN
     INVESAAASP TPYEENLYNG NGYTGYHGNG RASINGNESM VSGFNENGST FSGFNGNGYN
     TNENGAAQFV RRRLLPSIPK GNKPTFNFQC LQPQSSVDNL PIPAGSHPLF LFSQAQLSLD
     SRPSSVSSMS TASWANTAAA GTTPVPGLIA PSGRRGKLIY TPMILVDESS GTSQPLWSDG
     SASLPAGRRS AWYPGQTRTF TSVRMPPPVN PSFVEKGSAD SLVESILISE GLGIYARDPK
     FVNFAKREIA EACHMSLDEM ESAAADLI
//
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