ID H2MI56_ORYLA Unreviewed; 516 AA.
AC H2MI56;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Angiopoietin-like 1a {ECO:0000313|Ensembl:ENSORLP00000018329.2};
GN Name=angptl1a {ECO:0000313|Ensembl:ENSORLP00000018329.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000018329.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000018329.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000018329.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000018329.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000018329.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; H2MI56; -.
DR STRING; 8090.ENSORLP00000018329; -.
DR Ensembl; ENSORLT00000018330.2; ENSORLP00000018329.2; ENSORLG00000014624.2.
DR eggNOG; KOG2579; Eukaryota.
DR GeneTree; ENSGT00940000155091; -.
DR HOGENOM; CLU_038628_0_0_1; -.
DR InParanoid; H2MI56; -.
DR TreeFam; TF336658; -.
DR Proteomes; UP000001038; Chromosome 4.
DR Bgee; ENSORLG00000014624; Expressed in muscle tissue and 12 other cell types or tissues.
DR GO; GO:0062023; C:collagen-containing extracellular matrix; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central.
DR GO; GO:0001525; P:angiogenesis; IEA:Ensembl.
DR GO; GO:0060216; P:definitive hemopoiesis; IEA:Ensembl.
DR GO; GO:0002244; P:hematopoietic progenitor cell differentiation; IEA:Ensembl.
DR GO; GO:0045747; P:positive regulation of Notch signaling pathway; IEA:Ensembl.
DR GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IBA:GO_Central.
DR CDD; cd00087; FReD; 1.
DR Gene3D; 3.90.215.10; Gamma Fibrinogen, chain A, domain 1; 1.
DR InterPro; IPR036056; Fibrinogen-like_C.
DR InterPro; IPR014716; Fibrinogen_a/b/g_C_1.
DR InterPro; IPR002181; Fibrinogen_a/b/g_C_dom.
DR NCBIfam; NF040941; GGGWT_bact; 1.
DR PANTHER; PTHR19143:SF25; ANGIOPOIETIN-RELATED PROTEIN 1; 1.
DR PANTHER; PTHR19143; FIBRINOGEN/TENASCIN/ANGIOPOEITIN; 1.
DR Pfam; PF00147; Fibrinogen_C; 1.
DR SMART; SM00186; FBG; 1.
DR SUPFAM; SSF56496; Fibrinogen C-terminal domain-like; 1.
DR PROSITE; PS51406; FIBRINOGEN_C_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038}.
FT DOMAIN 296..516
FT /note="Fibrinogen C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51406"
FT REGION 58..78
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 269..299
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 182..209
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 58..75
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 516 AA; 58404 MW; 3FE858FB033BC444 CRC64;
MSSQIKSSLD DCKGGLEGTL AAVHQSFQPA AMQGLVWSLC VLLCLSLWEE SSCRSSRETQ
RTKEPFLKRS KRAPTDPNAK QCSYTFLVPE QRITGPICAS TTGPEPDKDR VTRMDIADVR
EVLNKQRREI ETLQLVVDVD GNLVNEMKLL RKESRNMNSR VTQLYMQLLH EIIRKRDNSL
ELAQLENRVL NVTSEMMRLA SRYKDLEARF ATIAGVVNNQ SVLITALEEQ CLRSLGQGER
AQAPPLVRAV PQNIPVDNRF TNEIQRNSRA FTRGSRKNSP TVSPFGIDPP PPQGTLTSDG
PFKDCYEVRQ AGHTTSGMYL LKTDNSDRLF QAWCEHGLDN GGWTVLQRRR GGAINFFRNW
DTYKKGFGNI DGEHWLGLEN IYNLSKQGDY KLMIELEDWA GKKVYAEYSS FHLESENQGY
RLRLGTYQGN AGDSLSSNNG KQFTTLDRDR DAFSGNCAHF HRGGWWYNDC GQTNLNGVFH
SGGVYRSKFQ DGIFWADYGG GFYSLKSVLL MIRPID
//
