ID H2MI81_ORYLA Unreviewed; 736 AA.
AC H2MI81;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=Nucleolar GTP-binding protein 2 {ECO:0000256|RuleBase:RU364023};
GN Name=gnl2 {ECO:0000313|Ensembl:ENSORLP00000018355.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000018355.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000018355.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000018355.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000018355.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000018355.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: GTPase that associates with pre-60S ribosomal subunits in the
CC nucleolus and is required for their nuclear export and maturation.
CC {ECO:0000256|RuleBase:RU364023}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000256|ARBA:ARBA00004604, ECO:0000256|RuleBase:RU364023}.
CC -!- SIMILARITY: Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2
CC subfamily. {ECO:0000256|RuleBase:RU364023}.
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DR RefSeq; XP_011483957.1; XM_011485655.1.
DR AlphaFoldDB; H2MI81; -.
DR STRING; 8090.ENSORLP00000018355; -.
DR Ensembl; ENSORLT00000018356.2; ENSORLP00000018355.2; ENSORLG00000014645.2.
DR GeneID; 101173497; -.
DR KEGG; ola:101173497; -.
DR CTD; 29889; -.
DR eggNOG; KOG2423; Eukaryota.
DR GeneTree; ENSGT00810000125524; -.
DR InParanoid; H2MI81; -.
DR OrthoDB; 2879109at2759; -.
DR TreeFam; TF105668; -.
DR Proteomes; UP000001038; Chromosome 16.
DR Bgee; ENSORLG00000014645; Expressed in gastrula and 14 other cell types or tissues.
DR GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR CDD; cd01858; NGP_1; 1.
DR Gene3D; 1.10.1580.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR030378; G_CP_dom.
DR InterPro; IPR024929; GNL2_CP_dom.
DR InterPro; IPR006073; GTP-bd.
DR InterPro; IPR023179; GTP-bd_ortho_bundle_sf.
DR InterPro; IPR012971; NOG2_N_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11089; GTP-BINDING PROTEIN-RELATED; 1.
DR PANTHER; PTHR11089:SF9; NUCLEOLAR GTP-BINDING PROTEIN 2; 1.
DR Pfam; PF01926; MMR_HSR1; 1.
DR Pfam; PF08153; NGP1NT; 1.
DR PRINTS; PR00326; GTP1OBG.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51721; G_CP; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134, ECO:0000256|RuleBase:RU364023};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU364023};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU364023};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038}.
FT DOMAIN 207..368
FT /note="CP-type G"
FT /evidence="ECO:0000259|PROSITE:PS51721"
FT REGION 1..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 481..509
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 534..605
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 655..736
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10..25
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 550..573
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 583..597
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 655..669
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 670..717
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 736 AA; 83479 MW; 8430745C9454582B CRC64;
MVKPKFKGKC SINPSSSSSN PDRAKGAGGN NMRDRATIKR LNMYRQKQRC NKHGKVIKPL
QYQSTVAPGT VARVEPNIKW FTNTRVIKQS SLQKFQDEMG AVQKDPYRVV MKQSKLPMSL
LHDRVKAHNS KVHILDTEGF ETTFGPKAQR KRPSLMVDDV KDLLERAEAS ALSYNSDQDK
DLVTEDTGVR EEAREEIFKK GQSKRIWGEL YKVIDSSDVI IQVLDARDPM GTRSKSIETY
LKKEKPWKHL IFVLNKCDLI PTWVTKRWVA VLSQEYPTLA FHASLTNSFG KGSLIQLLRQ
FGKLHTDKKQ ISVGFIGYPN VGKSSVINTL RSKKVCNVAP IAGETKVWQY ITLMRRIFLI
DCPGVVYPSE DSESDIVLKG VVQVEKIRNP EDHIEAVLER AKPEYVQKTY RIPSWNSTED
FLEKLAFRTG KLLKGGEPDI STVSKMVLND WQRGRIPFFV KPPGPEGDPE ADKLLPVEAP
PDAEESMQEE QTDASVSAEQ EEQQQQRKKE QVQKILANVR QNFGKINVAP EFSEEDLVPV
EMPDLDMSDF SGSEAEEEDA EDERLEEDDS NVDNDAEKST GDAEMSVPTN SQTETNMEKD
AKGSKQVLQE LDAKIAKYKH FLDRAKSKRF SAIRIPKALS DKVFTDVKTK QAAAKQAQKK
ASQTTAVNMK NKKRKVEEDD ESTQSRLTSK QRRAMERAQK VKKVGVRYYE SHNVKNKNRK
VPVSAAKGQR TKRSKQ
//
