ID H2MIC7_ORYLA Unreviewed; 686 AA.
AC H2MIC7;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=Neural cell adhesion molecule 1a {ECO:0000313|Ensembl:ENSORLP00000018404.2};
GN Name=ncam1a {ECO:0000313|Ensembl:ENSORLP00000018404.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000018404.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000018404.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000018404.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000018404.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000018404.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: This protein is a cell adhesion molecule involved in neuron-
CC neuron adhesion, neurite fasciculation, outgrowth of neurites, etc.
CC {ECO:0000256|ARBA:ARBA00003000}.
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DR AlphaFoldDB; H2MIC7; -.
DR Ensembl; ENSORLT00000018405.2; ENSORLP00000018404.2; ENSORLG00000014681.2.
DR eggNOG; KOG3510; Eukaryota.
DR GeneTree; ENSGT00940000155743; -.
DR TreeFam; TF326195; -.
DR Proteomes; UP000001038; Chromosome 14.
DR Bgee; ENSORLG00000014681; Expressed in brain and 14 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR CDD; cd00063; FN3; 2.
DR CDD; cd00096; Ig; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 7.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR009138; Neural_cell_adh.
DR PANTHER; PTHR12231; CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN; 1.
DR PANTHER; PTHR12231:SF239; NEURAL CELL ADHESION MOLECULE 1; 1.
DR Pfam; PF00041; fn3; 2.
DR Pfam; PF07679; I-set; 4.
DR PRINTS; PR01838; NCAMFAMILY.
DR SMART; SM00060; FN3; 2.
DR SMART; SM00409; IG; 5.
DR SMART; SM00408; IGc2; 4.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 5.
DR PROSITE; PS50853; FN3; 2.
DR PROSITE; PS50835; IG_LIKE; 4.
PE 4: Predicted;
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|ARBA:ARBA00022989};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022989};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 50..134
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 146..234
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 239..342
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 347..436
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 440..536
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 560..656
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
SQ SEQUENCE 686 AA; 75584 MW; 13E1602D9FE5A69F CRC64;
MQDLSVSRSD EVTSTLTIYH ANVDSAGIYK CVARDGEKEA QATVQVKIFQ KITFQSAPSP
QEFTEGDTAD IVCNVVSSPP PTIIWKHKGS KIQASKDVRY KIMANGHLQI RGIKKTDEGM
YTCEARVMAR GEIDFKTMKV VVNVLPTIRA RQFEVNATAD IGNSALLACD ADGFPDPIVT
WTHNNVVLEE GDKYSLNEDG SELIIKDVMK VDEGDYTCIA KNKAGEKSQE VSLNVFVQPK
ITYLNNKTAI EFDEEVILTC EASGDPTPTI SWSSESKIFT EGEQASWTRP DKYESLDRNI
VVYSHARVSS LTLKNVQFTY AGQYLCIASN SIGQDSQSVY LEVRYSPKIQ GVVASYTWEK
NPANLSCEVD AHPEASVVWF KDGSHLPSPN TTNVKIYNMP TVSYLEITPE SQIDFGNYNC
TATNDLGSES KEFILIQADV PSAPEIQQVE PFSSTAMVEF EEPDSTGGVP VLKYKVEWRF
PGEEWARKEY SKEDGKTKIL VTGLKPETTY EVKMSAINGK GEGESSAASF FKTKPVQYSF
TISSETLPSI AATILPLIGE PSAPKLEANV ADEGNSLRVT WIKQDDGGLP IIHYLVKYKA
KHVPEWKPEI RVPSLSEHTT LNGLAWNTEY EVHVVAENQQ GRSEPGIVSI KTAAQPTAIP
ATLGCQSVTC SLASLLLSVL TLLWLS
//
